Research works

Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR

Adhesion G protein–coupled receptors (aGPCRs) transduce signals via engagement of their large extracellular regions (ECRs) with adhesion partners. ADGRG6 (GPR126) is an aGPCR vital for the development of multiple organs and myelination. ECR conformational dynamics of ADGRG6 has b...

From Fog Chamber to Aircraft Window: Pixel-Registered Imaging and Synthetic Fine-Tuning Enable Cross-Domain Defogging

A deep defogging pipeline pretrained on controlled laboratory fog and fine-tuned with domain-randomized synthetic fog applied to clear outdoor scenes generalizes across a graded sequence of out-of-distribution settings with no target-domain training, from chamber-free free-flowin...

A quorum sensing antagonist with dual bacterium- and host-directed anti-pathogenic activity against Pseudomonas aeruginosa

Pseudomonas aeruginosa is a major opportunistic pathogen whose clinical management is increasingly compromised by antibiotic resistance and biofilm-associated persistence. Anti-pathogenic strategies that attenuate virulence without inhibiting bacterial growth offer a promising al...

Spiky Bursts of Energetic Electron Beams Upstream of Nonstationary Quasi‐Perpendicular Shocks

Abstract Energetic electron beams play a crucial role in collisionless shocks by driving upstream plasma waves and providing seed populations for diffusive shock acceleration. However, the processes responsible for their generation at quasi‐perpendicular shocks remain poorly unde...

Occurrence and controls of ~ 1 Hz waves in Mercury’s magnetosphere: insights from MESSENGER observations

<title>Abstract</title> Mercury’s magnetosphere is highly dynamic, with processes occurring on much shorter spatial and temporal scales than at Earth due to its weak magnetic field and proximity to the Sun. Wave-driven transport of energy and momentum is a key manifestation of th...

Racial and Ethnic Differences in Classic and 11-Oxygenated Androgens in Men

BACKGROUND: Androgen-dependent prostate pathology, including prostate cancer and benign prostatic hyperplasia, differs in prevalence and phenotype across races/ethnicities. Adrenal-derived 11-oxygenated C19 steroids (11-oxyandrogens) are relevant to several androgen-dependent pat...

Aortitis as a High-Risk Vascular Syndrome: Integrating Phenotype-Driven Diagnosis, Multidisciplinary Assessment, and Personalised Management

Aortitis—inflammation of the aortic wall—presents at the interface of vasculitis, infection, structural aortic disease, and cardiovascular risk. It may occur in giant cell arteritis (GCA), Takayasu arteritis, IgG4-related disease, drug-induced injury, infection, or as an isolated...

Context-Aware Maritime Navigation Efficiency Assessment: A Data-Fusion Framework with Metocean and Encounter-Based Validation

Maritime navigation efficiency is commonly assessed using isolated indicators such as route deviation, speed variation, fuel-related metrics, or traffic density, which do not fully reflect the operational context of a voyage. This study proposes a context-aware framework for asse...

Empowering PolymericMaterials Discovery by ArtificialIntelligence

Abstract Polymeric materials underpin modern technologies spanning energy storage, microelectronics, healthcare and sustainable manufacturing. Yet their rational design remains exceptionally challenging because material performance emerges from complex interactions among molecula...

Early Hidden-Crack Detection in Circular Magnetic Encoder Rings Through FM-AM Signal Decoupling

Early hidden cracks in circular magnetic encoder rings induce only slight magnetic perturbations at the incipient stage, yet they may evolve into missing-pole, demagnetization, or severe waveform-distortion faults that degrade angular-displacement measurement and closed-loop cont...

Amantadine, donepezil and memantine associated arrhythmia in an elderly patient

<title>Abstract</title> <bold>2.1 Case İnformation</bold> A 78 years old man was referred to the cardiology clinic because of mild dyspnea.Electrocardiography (ECG) showed sinus bradycardia at a rate of 59 beats/min, right bundlebranch block (RBBB), first-degree AV block, and nor...

Evaluating patient-controlled admissions in adolescent psychiatric care: a quantitative study

BACKGROUND: An agreement on Patient-Controlled Admissions (PCA) is enabling patients to initiate at brief inpatient stay, on their own initiative, outside the existing referral system, at a well-known ward. PCA has mostly been studied in adult psychiatry, and the purpose of the c...

Spectral Detection of Correlated Errors on Superconducting Quantum Hardware via Parity-Circuit Canaries

Version 7 - revised and extended technical preprint.This record contains Version 7 of Spectral Detection of Correlated Errors on Superconducting Quantum Hardware via Parity-Circuit Canaries.The manuscript studies pairwise excess joint-error probabilities using lightweight parity-...

Two new species of Princaxelia (Crustacea, Amphipoda, Pardaliscidae) from hadal depths of the Tonga and Mariana trenches (Pacific Ocean)

Princaxelia Dahl, 1959, is a genus containing predatory pardaliscid amphipods, typically captured in small numbers from hadal trenches (&amp;gt; 6,000 m ocean depth). Here, two new species, Princaxelia malohi Duffy &amp; Wainwright, sp. nov . and Princaxelia kahat Duffy &amp; Wai...

Histological aging signatures for monitoring tissue-specific aging and disease

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types acro...

Fitness for Purpose of Reactive Nitrogen Monitoring Methods in Ecosystems: A Multi-Faceted Comparative Assessment

Anthropogenic reactive nitrogen (Nr) production now greatly exceeds natural creation, generating cascading environmental impacts on the environment and human health. Effective monitoring of Nr in ecosystems is essential for early warning and policy response, yet the landscape of...

First Retrieval of Formic Acid from GOSAT-2 Thermal–Infrared Observations over Land

Formic acid (HCOOH), the most abundant carboxylic acid in the troposphere, modulates rainwater acidity, aerosol water uptake, and the oxidative capacity of remote atmospheres, yet its global budget remains poorly constrained. Herein, we present the first HCOOH total-column retrie...

An Adaptive Shooting and Bouncing Ray Method Based on Q-Learning for Efficient Synthetic Aperture Radar Imaging Simulation

Fast synthetic aperture radar (SAR) imaging simulation is required by many computer vision applications. Although the shooting and bouncing ray (SBR) method has significantly accelerated electric field calculation, the number of ray tubes is still the bottleneck for SAR image sim...

Observation-based analysis of horizontally oriented ice crystals using dual-angle polarization lidar and cloud Doppler radar in Beijing

Abstract. Ice crystal orientation strongly influences cloud radiative properties and remote sensing retrievals, but long-term, high-resolution quantitative observations remain scarce. This study presents comprehensive case studies and statistical analyses of horizontally oriented...

On the Bottom‐Up Construction of Many‐Electron Relativistic QED Hamiltonian

ABSTRACT It was shown more than a decade ago [J. Chem. Phys. 139, 014108 (2013)] that a many‐electron relativistic quantum electrodynamics (QED) Hamiltonian for high‐precision electronic structure calculations can be constructed in a bottom‐up fashion, by virtue of charge‐conjuga...