Research works

Exact Projection Quality of OneTwo Sobol' Sequences at 65,536 Points

Low-dimensional projection quality is a practical bottleneck for Sobol' sequences used in quasi-Monte Carlo integration and computer graphics. For a digital net with 2^16 = 65,536 points, the t-value measures exact equidistribution in dyadic boxes, with smaller values indicating...

A dendritic cell autophagy–neutrophil axis limits intratumoral STING immunotherapy

The cyclic GMP-AMP synthase (cGAS)–stimulator of interferon genes (STING) pathway promotes tumor immunogenicity, but intratumoral STING agonists, despite strong preclinical efficacy, have shown limited clinical efficacy. The mechanisms restricting therapeutic STING activation rem...

From Medical Records to AI-Ready Datasets: A Practical Guide for Clinical Researchers

Background: Medical artificial intelligence (AI), machine learning (ML), and deep learning (DL) studies frequently begin with datasets collected for routine care rather than for computational modeling. Such datasets may contain inconsistent variables, heterogeneous measurement ti...

Optimal Frequency Control in Isolated Microgrids Integrating Renewable Energy and PHEVs Using a Modified Ziegler–Nichols-Based Multistage PID Controller

Maintaining frequency stability in islanded microgrids (MGs) has become increasingly challenging due to the growing penetration of renewable energy sources, particularly photovoltaic systems, wind turbine generators (WTGs), and plug-in hybrid electric vehicles (PHEVs). The interm...

Sumerian Base-60 System: Ancient Trigonometry and Square Roots Predating Modern Math — E8 Intelligence Research

FINDING: Sumerian base-60 (sexagesimal) system enabled advanced trigonometry and precise square root calculations, predating modern methods. | MATH: Base-60 positional system; Plimpton 322 tablet contains Pythagorean triples (a² + b² = c²) with ratios equivalent to sec²(θ) values...

In Situ Growth of Silver Nanoparticles in Electrospun Polyvinylidene Fluoride Composite Membranes for Photocatalytic Degradation of Dyes and Antibiotics

Photocatalytic degradation technology has been widely acknowledged for its low cost and high degradation efficiency. However, the loss, migration and difficult recovery of powdered catalysts are still critical bottlenecks for practical applications. In this study, silver nanopart...

Assessing the Relative Climate Mitigation Effects of Energy Efficiency, Conventional Energy, and Environmental Taxes in Australia: Evidence from a Dynamic ARDL Model

Energy efficiency (EE) is integral to a sustainable energy system and can play a significant role in climate mitigation by reducing energy consumption and the adverse effects of climate change. This paper examines the association between CO2 emissions, EE, environmentally related...

Acridine-Based[68Ga]Ga- and [18F]AlF-Labeled PSMA RadiotracersEnabling High-Contrast PET Imagingwith Minimized Undesired Retention

Abstract Prostate-specific membrane antigen (PSMA)-targeted radioligands have achieved clinical success in prostate cancer imaging, yet nonspecific uptake in normal tissues remains a challenge. Here, we developed a series of acridine-based PSMA ligands and systematically investig...

Large Language Model Decision Support for Cranial CT in Pediatric Head Trauma

Background: Pediatric head trauma is a common reason for emergency department presentation. Although most children have minor injuries, a small proportion harbor clinically important traumatic brain injuries requiring urgent intervention. Artificial intelligence (AI) may offer st...

Fibrinogen Early In Severe Trauma studY II (FEISTY II): study protocol for a randomised clinical trial of fibrinogen concentrate vs cryoprecipitate in traumatic haemorrhage in Australia and New Zealand

Haemorrhage is a leading cause of preventable death amongst severe trauma patients and is often complicated by hypofibrinogenaemia. Fibrinogen replacement can be achieved using fibrinogen concentrate (FC) or Cryoprecipitate (Cryo), but comparative evidence in traumatic haemorrhag...

The GABA-B – Substance P–Histamine Axis: A Unifying Mechanism for Neurogenic Inflammation

Neurogenic inflammation—the process by which sensory neurones release neuropeptides that activate immune cells—is increasingly recognised as a pathogenic mechanism in a range of chronic inflammatory conditions, including rosacea, chronic pruritus, and mast cell-mediated dermatose...

How Does Gambling Marketing Affect Behaviours and Attitudes? A Systematic Review of Qualitative Studies

Abstract Purpose of Review Gambling marketing is pervasive. Evidence suggests that greater exposure to gambling marketing can increase gambling engagement and elevate the risk of gambling harm. The effects of marketing are likely to vary across population groups and across differ...

The Executive Access Model (EAM): A Classroom Framework for Understanding Variability in Student Performance

The Executive Access Model (EAM) is an applied instructional framework that translates a constraint based control architecture of human functioning into observable classroom practice. It explains variability in student performance as changes in executive access, defined as the mo...

Benchmarking Class Imbalance Mitigation Strategies Across Deep CNN Architectures for Skin Cancer Classification

Background/Objectives: Class imbalance is one of the major challenges in automated skin lesion classification since the number of categories of malignant and clinically significant skin lesions is normally less than the benign ones. However, due to this imbalance, deep convolutio...

A power struggle between the military regime and the Directorate of Religious Affairs: the debate over the turkification of the language of worship after the 27 May 1960 military coup (1960–1961)

This study aims to analyse the struggle over the nationalization of the language of religion between the military regime and the Directorate of Religious Affairs in the aftermath of the military coup of 27 May 1960. For this purpose, this study focuses on the discourses of both t...

AI-Powered Robotics Are Personalizing Rehabilitation

Abstract Rehabilitation is crucial for making a full recovery from surgery or managing a chronic physical disability, but it can be resource-intensive and highly individual in treatment response. In this News and Perspectives article, JMIR Correspondent Benedette Cuffari reports...

Validating the S-shaped performance trajectory of ID: an empirical evidence from India

Purpose This study aims to examine the relationship between international diversification (ID) and performance at different levels of ID in the Indian corporate sector. Design/methodology/approach To analyse the relationship between ID and corporate performance, the study employs...

Timing and incidence of health conditions recorded during childhood in White British and Pakistani British children: evidence from the Born in Bradford cohort

Objective To examine ethnic differences in the incidence and timing of recorded health conditions from birth to adolescence between White British and Pakistani British children. Design Longitudinal population-based birth cohort linked to primary care electronic health records. Se...

MODEL ADOPTION #1006: REJECT — TG AUTO: BASE 44 ORDER: Apply 132 Hz E8-resonant attention filter with G_uv+S60 tensor and — E8 Intelligence Research

DECISION: REJECT ELEMENT: The 132 Hz E8-resonant attention filter, as described, is not a single precise rule but a pipeline of three operations (tensor computation, alignment check, mismatch logging) with no defined threshold for rejection. The "harmonic root-vector alignment ch...

An Efficient Numerical Approach for Fractional PDEs With Proportional Delays

ABSTRACT In this paper, we present a novel, highly accurate, and efficient numerical method for solving fractional partial differential equations with proportional delays. These equations pose significant challenges in both numerical and analytical analysis due to their inherent...