Research works

The Illusion of Generalization: Impact of Ultra-Low Synthetic Contamination on Deep Waveform AI Scratch Training in Acoustic Leak Detection

This paper investigates the fundamental problem of false adaptation in deep neural networks applied to non-destructive testing (NDT) of pipelines. Under severe field data shortages, developers often rely on surrogate audio files generated by rapid, heuristic methods (such as LLM-...

Nasopharyngeal Carcinoma With Multiple Metastases Detected by Al 18 F-NOTA-FAPI-04 PET/CT

Nasopharyngeal carcinoma (NPC) is a prevalent epithelial malignancy. NPC tends to infiltrate locally early and typically involves regional nodes. Patients with terminal disease often develop distant metastases. We report a case of NPC with multiple metastases on 18 F-FAPI-04 PET/...

Reduced IP6K levels impair life-cycle transitions and intracellular development of Trypanosoma cruzi within human cardiomyocytes

Trypanosoma cruzi is the etiological agent of Chagas disease (CD). During its life cycle, T. cruzi undergoes several key differentiation processes that are essential for its survival. The precise mechanisms that regulate these processes remain elusive, and any interference in thi...

BASE 44 ORDER: Build breakthrough_sentiment_cache with hash index, eviction timer, parallel batch — E8 Intelligence Research

Andrew's order (Base 44 console): [SELF-BUILD from enhancement #1095] Add table breakthrough_sentiment_cache with FK, jsonb, timestamptz, int. Hash index on breakthrough_id, btree on access_count. Modify Python retrieval: check cache, on miss LLM call, store with count=1. On hit...

Detection and Distribution of Tick-Borne Bacterial Pathogens in Ticks from Different Hosts in the Altun Mountains, China

Background: Ticks are the main vectors for a variety of tick-borne bacterial pathogens. Systematic studies on the coinfection patterns and differences of pathogens in ticks derived from different hosts are of great significance. Therefore, the present study investigated ticks col...

A quantitative and visual detection probe based on isothermal nucleic acid amplification coupled with CRISPR/Cas12a system (INACS) for miR155 detection

MicroRNAs (miRNAs) have emerged as ideal biomarkers for early clinical diagnosis. Achieving the accurate detection of miRNAs plays a critical role for assuring its implementation in their clinical applications. In this study, we developed a dual-signal amplified ultrasensitive fl...

Diagnostic performance of a field-deployable iiPCR platform and viral load dynamics of MPXV Clade IIb in a cohort with high prevalence of HIV

BACKGROUND: Since 2022, the global outbreak of Mpox caused by the Mpox virus (MPXV) Clade IIb has underscored the need for timely and decentralized molecular diagnostics. Although quantitative real-time PCR (qPCR) remains the diagnostic gold standard, its infrastructure requireme...

From Inside to Outside: A Scoping Review of Connections in Care Buildings and Their Impact on End-Users’ Experiences

Aim This scoping review aims to provide insight into how various connections between indoor and outdoor environments in care buildings affect end-user experiences and use of space. Background Numerous studies highlight the beneficial effects of outdoor interaction on end-users’ p...

A low-cost ground-based NDVI imaging solution (ViperPics) for vegetative remote sensing

Human beings have been directing technology markets according to their needs. With the help of computers, algorithms, sensors, and various internet of things (IoT), systems are now being supported by artificial intelligence. New generations have been witnessing the rapid integrat...

Changes in Outpatient and Telehealth Visits Among Undocumented Patients

Importance Anti-immigration policies in 2025 may influence outpatient care and telehealth among immigrant communities. Understanding visit patterns is essential for health systems leaders to prepare for shifts in health care use and ensure preventive care. Objective To compare ou...

Residual Inflammatory Potential in Patients with Treated Non-Definite and Definite Familial Hypercholesterolaemia: A Clinical Study

Background: Familial hypercholesterolemia (FH) is associated with accelerated atherosclerosis and an increased risk of cardiovascular disease. Aims: To evaluate circulating biomarkers of inflammation and atherosclerosis in patients with clinically suspected FH stratified accordin...

Validity of Using Artificial Intelligence to Predict Skeletal Maturation in Orthodontic Treatment: A Systematic Review and Meta-analysis

Abstract This systematic review aimed to evaluate the performance and clinical validation of artificial intelligence (AI) and rule-based methods for skeletal maturation assessment using cervical vertebral maturation (CVM) and hand–wrist radiography. The review was conducted in ac...

Unauthorized Optimization Across Domains

Optimization is a powerful and ubiquitous process across domains. When properly authorized, it enables adaptation, efficiency, and resilience. When unauthorized, it produces failure modes that appear disparate on the surface yet share a common structural form. This paper presents...

Employment of Adults With Autism Spectrum Disorder: An Integrative Review of Barriers and Facilitators

Abstract Purpose This study aimed to synthesize the international literature on the employment of adults with autism spectrum disorder (ASD), identifying the main barriers and facilitators influencing access, inclusion, and retention in the labor market. Methods An integrative re...

Wheel Diameter Affects Vibration Transmission but Not Performance During Uphill and Downhill Mountain Biking over Rough Terrain

Mountain biking over rough terrain exposes riders to vibrations that may affect comfort, health, bicycle control, and performance. This study analyzed the effect of wheel diameter on vibration transmission and performance during a short uphill and downhill test over rocky terrain...

Genetic disorders associated with neurodevelopmental disorders in children in Saudi Arabia: A systematic review and meta-analysis

Objectives: High consanguinity in Saudi Arabia has shaped the genetic architecture of pediatric neurodevelopmental disorders (NDDs), potentially increasing autosomal recessive (AR) etiologies and the diagnostic yield of exome-based testing. This study aims to synthesize genetic d...

Thiram Disrupts Hepatic and Tibial Calcium Homeostasis via ER Stress‐Mediated IP3R1 / VDAC1 Hyperactivation

ABSTRACT Thiram is an agricultural fungicide known to disrupt cellular calcium homeostasis by inducing endoplasmic reticulum (ER) stress and mitochondrial calcium overload in hepatic and growth plate (GP) tissues. Current study investigated thiram‐induced alterations at mitochond...

Comparative Clinical Outcomes of Various Colorectal Endoscopic Submucosal Dissection Techniques: A Systematic Review and Network Meta-Analysis

Background/Aims: Traction-assisted endoscopic submucosal dissection (T-ESD), hybrid ESD (H-ESD), pocket-creation method ESD (P-ESD), and underwater ESD (U-ESD) were introduced to overcome the limitations of conventional ESD (C-ESD). We conducted a systematic review and network me...

The AI Colleague: Reimagining Interprofessional Collaboration and Education in Medicine

Abstract AI is no longer confined to optional decision support; it is becoming a routine presence in clinical workflows, shaping diagnostic hypotheses, triage priorities, risk estimates, and documentation. Yet most educational responses still treat AI as a tool operated by an ind...

Suicide and Medical Illness: A Latent Class Analysis of Coroner Records in Toronto

OBJECTIVE: People with chronic illnesses are at elevated risk of suicide. Prior research has focused on risk with specific diagnoses and/or comparisons with living controls; the profiles of medically ill people who die by suicide remain largely unknown. This study aims to identif...