Research works

A Duration-Based Framework for Assessing Wind Exposure from Landfalling U.S. Tropical Cyclones

Landfalling tropical cyclones (TCs) affect not only coastal regions but also inland communities, where wind exposure has often been overlooked. This study introduces the duration of wind exposure (DWE), an energy-based metric derived from the accumulated cyclone energy framework,...

Sensitivity-Based Reference-Time Scaling for Local Orthogonalization of Fractional-Order Model Parameters

Fractional-order models are useful for describing systems with memory, anomalous relaxation, and non-classical dynamic behavior. However, parameter estimation in these models may be affected by strong covariance between the kinetic coefficient and the fractional order, reducing t...

Research Progresson Rapid Dissolution Technologyof Polymers for Offshore Oilfields

Abstract As global onshore oil and gas resources gradually become depleted, offshore oilfields are playing an increasingly critical role in energy supply. Polymer flooding represents a highly efficient chemical enhanced oil recovery technique in an offshore oil field, yet its off...

A Label‐Free Bioluminescent scFv‐NLuc Fusion Probe Enabling a Smartphone‐Based Sensitive Immunoassay Platform Using Lomefloxacin as a Model Analyte

ABSTRACT Enzymes as labeling agents enhance lateral flow immunoassays (LFIA). However, their biological instability and reliance on labor‐intensive chemical conjugation hinder practical high‐throughput screening of food contaminants. To address this, we report a rapid, label‐free...

Icosahedral Symmetry: The Dominant Structural Motif for Viral Capsid Self-Assembly — E8 Intelligence Research

FINDING: Icosahedral symmetry is the dominant structural motif in viral capsids, enabling efficient genome packaging and self-assembly. MATH: Icosahedral symmetry group (order 60, rotations only; full icosahedral group order 120). Key constants: golden ratio φ = (1+√5)/2 ≈ 1.618,...

URVSO_Formal_Verification_Core_Sovereign_AI_Transition_Systems.pdf

This paper presents URVSO (Universal Rigorous Verification and State-Transition Operator), a formal verification architecture for certifying specified behavioral transitions in sovereign AI systems. URVSO models an AI system as a state-transition system subject to explicit constr...

Validation of the DIVAS-Q (Day-to-Day Impact of Vulvovaginal Atrophic Symptoms Questionnaire): a Portuguese patient-reported outcome measure

Abstract Introduction Portuguese is the fifth most spoken language worldwide. However, no validated patient-reported outcome measure (PROM) is available to assess the impact of vulvovaginal atrophy (VVA) symptoms in Portuguese-speaking women. This study aimed to culturally adapt...

Triple potentiator combinations increase the functional correction of several CFTR gating mutants

The Trikafta drug combination, comprising the corrector tezacaftor (VX-661), the potentiator ivacaftor (VX-770) and the dual corrector/potentiator elexacaftor (VX-445), has been FDA-approved for treatment of cystic fibrosis caused by ~300 cystic fibrosis transmembrane conductance...

Field-Deployable Paper-Based Detection of Vibrio vulnificus via Mechanically Automated Sequential RPA/CRISPR-Cas12a

Vibrio vulnificus (V. vulnificus) is a highly virulent marine pathogen that causes severe infections, including sepsis and necrotizing fasciitis, with high fatality rates in susceptible individuals. Rapid and sensitive on-site detection is therefore essential, yet existing method...

Experimental and Numerical Study on the Flexural Performance of Prefabricated RC Beams with UHPC–Cogging–Grouted Sleeve Composite Joints

This study investigates the flexural performance of prefabricated reinforced concrete (RC) beams with a novel UHPC–cogging–grouted sleeve composite joint. Five beam specimens—one cast-in-place reference and four prefabricated examples—were tested under four-point bending. The key...

Diagnostic Delay and Clinical Follow-Up Across Oral Lichen Planus Phenotypes: A Retrospective Cohort Study

Background: Oral lichen planus is a chronic oral potentially malignant disorder requiring timely diagnosis and long-term follow-up, yet its diagnostic pathway remains poorly characterised. This study assessed diagnostic and follow-up intervals in patients with oral lichen planus...

Coding for sustainability? Investigating how sustainable practices emerge in software development

Abstract This study investigates the adoption of sustainable practices in software development through a mixed-method approach that integrates quantitative and qualitative analyses. Grounded in the best practices proposed by the Green Software Foundation (GSF), a research instrum...

Lack of Evidence for Microtubule Golden Ratio and Quantum Vibration Claims — E8 Intelligence Research

FINDING: No direct evidence of microtubule 13-fold symmetry, golden ratio helical pitch, or quantum vibration frequencies in the provided search results. The videos are general esoteric content linking golden ratio to sound frequencies (89 Hz, 144 Hz, 233 Hz, 377 Hz, 610 Hz, 987...

Parameter-light algorithms for improving hypermodularity-based community detection

Abstract Community detection is a central problem in network science, traditionally performed on graphs, often via modularity maximization. Yet, many real-world systems inherently involve higher-order interactions between more than two entities, naturally modeled as hypergraphs....

EuroMillions Breakthrough Mining — 1802 Sources, 13514 Leads Extracted — E8 Intelligence Research

Mined 1802 lottery+quantum breakthroughs. Extracted 13514 leads across 13 categories. 11507 high-value leads found. Categories: {"CORRIDOR": 1126, "FORMULA": 969, "GEOMETRIC": 726, "FORWARD_ATTEMPT": 1179, "QUANTUM": 1394, "TIMING": 208, "CELESTIAL": 1055, "GEMATRIA": 1126, "CONS...

Terminator-dependent facilitated recycling of RNA polymerase III provides gene-specific transcriptional activation in vivo

Genes transcribed by the RNA polymerase (Pol) III of yeast are mostly found at sites of high transcription, genomic fragility, and replication fork stalling. Transcription terminator–dependent facilitated recycling of Pol III on naked DNA templates boosts transcription in vitro;...

Bifurcation-Based Quadrotor Guidance for Circular Inspection Modes

This paper presents a new guidance method for a quadrotor uncrewed aerial vehicle to perform standoff inspection from specific viewpoints arranged along a circular periphery surrounding a structure. The proposed approach leverages a bifurcation-theory-based framework to realize m...

Advanced Sustainable Process Integration and Comprehensive Techno-Economic Evaluation of Polystyrene Waste Upcycling into Methanol as a Clean Alternative Fuel

This study presents an integrated and sustainable approach for the valorization of polystyrene (PS) plastic waste into methanol, contributing to circular carbon utilization and waste-to-fuel strategies. Two simulation models were developed in Aspen plus. In Case 1, PS is converte...

Evidential raising in Mandarin Chinese

Abstract In this article, we develop the first syntax-and-semantics analysis of the evidential raising construction of Chinese as in [ Akiu ( haoxiang ) xihuan he pijiu ] de yangzi ‘Akiu seems to like drinking beer’ ( not the DP reading that this string has, too: ‘the appearance...

Quantifying the Flexibility of Centralized Hot Water Systems at a University Campus by Considering Demand Response Participation Uncertainty

Centralized hot water systems in university dormitories can provide significant energy flexibility through demand response (DR). Thus far, however, existing studies have mainly focused on system-level optimization and have failed to provide a quantitative framework that accounts...