Research works

Silent allies: non-living microbes shaping the future of cardiometabolic health

Background Metabolic syndrome and its components constitute significant global health challenges, and growing evidence links their development to gut microbiota disturbances and altered microbial metabolites. Postbiotics have emerged as promising alternatives to traditional probi...

Criterion A in developmental coordination disorder: Is motor competence efficiently assessed? A systematic review and meta-analysis of mixed evidence from standardized assessments

Background Standardized motor batteries are widely used to assess motor competence in children with developmental coordination disorder (DCD), although it remains unclear whether they consistently capture the domains most affected by the disorder . Aims This systematic review and...

Pre-trained knowledge transfer with application in multisystem inflammatory syndrome subphenotyping in children

Multisystem inflammatory syndrome in children (MIS-C) is a severe post-acute sequela of SARS-CoV-2 infection in children and presents with highly heterogeneous signs and symptoms. Disentangling the clinical manifestations of MIS-C by characterizing its subphenotypes can help iden...

Susceptibility haplotypes in non-cystic fibrosis newborns with elevated immunoreactive trypsinogen

Cystic fibrosis (CF) represents the most prevalent life-threatening autosomal recessive disorder in Europe, primarily affecting the respiratory tract, exocrine pancreatic function, and lipid metabolism. Immunoreactive trypsinogen (IRT) quantification constitutes the first-tier te...

Machine learning and deep learning techniques for effective supply chain management

The growth in data volume and complexity of decision-making create the need for new data analytics methods, such as machine learning (ML) and deep learning (DL), which are critical for improving various tasks in supply chain management (SCM). Recent studies have highlighted the b...

A new type of hybrid bream derived from a hybrid of Megalobrama amblycephala (♀) × Xenocypris davidi (♂)

Blunt snout bream ( Megalobrama amblycephala , BSB, 2 n = 48) is an endemic and economically important freshwater fish in China, characterized by its ease of culture, rapid growth, and high meat quality. However, the industry faces challenges such as germplasm degradation and a l...

FABP4 and L-acetylcarnitine as candidate biomarkers for small airway dysfunction in children with obese type 2 asthma: a pilot cross-sectional multi-omics study

Childhood obesity-associated asthma represents a distinct phenotype with incompletely understood metabolic mechanisms. This hypothesis-generating study aimed to screen candidate biomarkers associated with small airway dysfunction in children with obese type 2 asthma and explore p...

Eco-friendly biosynthesis of silver nanoparticles with Amyntas morrisi earthworm extract and its antibacterial activity

Earthworms are soil-dwelling macroinvertebrates that contribute significantly to soil fertility and productivity. In India, various tribes have used earthworms to address diverse health issues. A native earthworm species, identified as Amyntas morrisi , was isolated from Kodaikan...

Longitudinal Changes in Pituitary Area in Individuals Undergoing Magnetic Resonance Imaging Checkups

Background: The aim of the study was to investigate longitudinal changes in pituitary area and their associations with baseline characteristics and lifestyle factors in individuals undergoing brain magnetic resonance imaging (MRI) checkups. Methods: A retrospective analysis was p...

Topic Modeling-Based Analysis of Research Trends in Dementia Studies: 2000~2025

치매정책과 사회적 담론에 직·간접적인 영향을 미치는 치매연구는 예방, 진단, 치료 및 생활 지원 등 다양한 측면에서의 접근이 필요하다. 국내 치매연구의 양과 질이 빠르게 증가하는 가운데 그동안의 연구 주제의 변화를 살펴보는 것이 필요하다. 본 연구에서는 2000년 이후 2025년 4월 30일까지 RIS...

Median effective infusion rate (ED50) of continuous cisatracurium for preserving interpretable TceMEP signals during intraspinal tumor resection: a prospective up-and-down sequential allocation study

Intraoperative neurophysiological monitoring (IONM), particularly transcranial electrical stimulation motor evoked potentials (TceMEP), plays a crucial role in preserving motor function during intraspinal tumor resection. However, neuromuscular blocking agents (NMBAs) may attenua...

Development and external validation of a nomogram for overall survival in oral tongue squamous cell carcinoma using machine learning-assisted feature selection

This study aimed to identify prognostic factors using machine learning-assisted feature selection and develop a Cox-based nomogram for predicting 2-year and 5-year overall survival in Oral Tongue Squamous Cell Carcinoma (OTSCC). Clinical data from 5746 OTSCC patients in the SEER...

Induction of interleukin-6 by anti-ribosomal P protein immunoglobulin G3 autoantibody in monocytes through Fcγ receptor cross-linking

Kaho Sato, M.D., Hiroe Sato, M.D., Ph.D., Tomoya Watarai, M.D., Ayako Wakamatsu, M.D., Ph.D., Daisuke Kobayashi, M.D., Ph.D., Suguru Yamamoto, M.D., Ph.D., Yoshikatsu Kaneko, M.D., Ph.D.. J Rheum Dis -0001;0:. https://doi.org/10.4078/jrd.2026.0017

P1D6 inhibits FnBP-induced extracellular proteome remodeling: proteomic evidence for a novel intervention strategy in atopic dermatitis

Atopic dermatitis (AD) is an inflammatory skin disorder characterized by skin barrier impairment, chronic inflammation, and intense pruritus. Staphylococcus aureus ( S. aureus ) critically contributes to its pathogenesis; however, the mechanistic role of its virulence factor fibr...

A conserved miR-7132a/SOCS1/STAT2 regulatory axis enhances type I IFN antiviral responses in teleost fish

Type I interferon (IFN) signaling plays an essential role in restricting viral infection. Accumulating evidence indicates that microRNAs (miRNAs) serve as key regulators of the type I IFN signaling in mammals. However, whether the miRNA-mediated regulation is involved in type I I...

Three-dimensional spatio-temporal propagation dynamics from soil moisture to vegetation droughts across different eco-geographical regions of China

Study region China. Study focus This study investigated the propagation from soil moisture drought (SD) to vegetation drought (VD) across China during 1981–2020 using a three-dimensional (3-D) spatio-temporal clustering framework. SD and VD events were identified based on the Sta...

Passive sampling reveals composition of airborne bacteria and fungi across five East African cities

Airborne microbes significantly influence environmental processes and human exposure, yet they remain poorly characterized in Africa. This study presents a regional survey of airborne bacterial and fungal communities across 10 sites in five East African countries: Burundi, the De...

CantataS: a Community-aware agent-based citation Simulator

Early preprint describing CantataS, a generative agent-based model of citation dynamics that builds upon the PyABM, SASCA, SASCA-s, SASCA-ReS, and SASCA-ReSA models. This preprint is likely to be updated several times as more data is generated through simulations under the Cantat...

The Picken Complete Taxonomy for AI Governance: A Unified Instrument Framework for Board-Level AI Governance Assessment, Liability Pricing, and Sector Contagion Modelling

AI governance research has, to date, developed largely as a series of independent instruments, each addressing a discrete failure mode — regulatory exposure, vendor credibility, sector-specific liability — without a unifying framework describing how these instruments relate to on...

"From Innovation to Market" White Paper

As part of the Security Mission Information & Innovation Group (SMI2G) event, held on 23–24 April 2026 at the Conseil régional d'Île-de-France, Paris, France, the panel discussion "From Innovation to Market" brought together panellists who shared their experience in research and...