Research works

High-Precision Visual Absolute-Localization Method for Deep-Space Probes Based on Salient Landmarks

To address the scarcity of high-precision control points on planetary surfaces and the accumulated drift of conventional relative-localization methods in deep-space exploration missions, this paper proposes a visual absolute-localization method based on salient-landmark contour m...

Mediating Roles of Barriers and Mitigation in Community-Based Health Adaptation to Floods: A Comparative Study in Bandung and Bojonegoro

This study investigates the mediating roles of barriers and mitigation strategies in community-based health adaptation to floods, comparing two contrasting Indonesian regions: urban Bandung and rural Bojonegoro. A cross-sectional survey was conducted with 201 participants (98 fro...

Hattrick against Lymphoma with Trispecific CAR T Cells

Vasu and colleagues report one of the first clinical evaluations of rapidly manufactured trispecific chimeric antigen receptor T cells targeting CD19, CD20, and CD22. The lymphoma efficacy signal and favorable observed safety profile support further investigation, whereas the cor...

Systematic pathway engineering of Escherichia coli for enhanced 3’-sialyllactose production

3’-Sialyllactose (3’-SL), the simplest sialylated human milk oligosaccharide (HMO), is widely incorporated into infant formula due to its roles in shaping the gut microbiota, inhibiting pathogen adhesion, and supporting neurodevelopment. In this study, we developed an efficient m...

Acceptability of Internet-Based Therapy: Considerations Expressed by Individuals Struggling with Gambling

Aims Internet-based therapy (IBT) is effective in reducing symptoms of gambling disorder (GD), yet limited acceptability may constrain treatment uptake and engagement. This study explored perspectives on the expected acceptability (defined as perceiving the intervention as approp...

Space debris and outer space sustainability: legal challenges

By 2025, humankind had reached a turning point in space. The orbital environment, once considered effectively unlimited, is now increasingly understood as a finite and congested operational domain. This article presents an in-depth evaluation of the legal and policy regimes for s...

Persona-centric Metamorphic Relation Guided Robustness Evaluation for Multi-turn Dialogue Modeling

Abstract Retrieval-based dialogue systems aim to select a proper response according to multi-turn conversational history. Persona-based conversation utilizes prior knowledge to maintain persona consistency, enhancing retrieval accuracy. However, reference-based evaluation relies...

Primary Eosinophilic Granuloma of Lymph Node: Case Report of an Enigmatic Disease

Eosinophilic granuloma with solitary involvement of a lymph node is very rare. It occurs mainly in children. We present a rare case report of an adult male with primary eosinophilic granuloma of a lymph node, which had regressed following fine-needle aspiration cytology (FNAC) an...

Understanding, assessing and managing shock in adults

Shock is a potentially life-threatening condition characterised by impaired perfusion of tissues and organs and inadequate cellular oxygenation. If left untreated, shock can lead to organ dysfunction, organ failure and death. This article explores the pathophysiology of shock and...

Competency frameworks for primary care rehabilitation professionals: a scoping review of global practices and implications for developing countries

PURPOSE: Integrated rehabilitation eases chronic mobility dependence, yet competency frameworks struggle to be implemented in resource-limited regions. To map global competency frameworks for primary care rehabilitation professionals and identify specific implications for workfor...

Relationship between neck weakness in motor neurone disease and respiratory function: a retrospective study

AIMS: The primary aim was to explore the relationship between neck weakness in people with motor neurone disease (MND) and their respiratory function. The secondary aim was to identify whether neck weakness can be a prognostic factor. METHODS: This was a retrospective observation...

Firearm carrying practices and motivations: A mixed methods study among adults and youth

Abstract The purpose of this participatory action, mixed methods research study was to identify motivations related to firearm carrying from a qualitative perspective, and then to use quantitative research to characterize the patterns of motivations around carrying. Qualitative i...

Are we well? Burnout among healthcare workers

SUMMARY Burnout refers to a psychological condition arising from prolonged and ongoing interpersonal stressors, resulting in physical and emotional exhaustion. Its prevalence among healthcare workers has been increasingly recognised as a significant factor affecting their mental...

Leadership Deflection and Systemic Inertia: Implications for Equity in Ethnically and Linguistically Diverse Schools

This article explores how school leaders working in ethnically and linguistically diverse schools operating within a centralized system position themselves in the face of tensions created at the meso- and micro-levels by the structural gaps at the macro level. Using data from a q...

Aquatic predators as complementary tools for mosquito vector control: current evidence, ecological considerations, and future directions

Insecticide-based strategies for mosquito control are increasingly constrained by insecticide resistance, sparking interest in eco-friendly alternatives, one of which is the use of aquatic predators to reduce mosquito densities. Evidence from laboratory, semi-field, and localized...

Divan Şiirinde Osmanlı İlim ve Düşünce Dünyasının Temeli Müderris

Osmanlı Devleti’nin merkez teşkilatı kendi içerisinde belli bölümlere ayrılmıştır. Bu bölümlerden biri toplumda dinî hizmetler, öğretim ve yargı faaliyetlerini icra eden görevlilerden oluşan ilmiye teşkilatıdır. Osmanlı Devleti’nin öğretim faaliyetlerinin merkezinde medreseler ve...

Machine learning-driven prediction and optimization of turbulence-enhanced multi-effect distillation system for efficient water treatment

Multi-effect distillation (MED) is one of the most energy-efficient thermal desalination technologies for freshwater production using low-grade heat; however, its performance is constrained by limited heat-transfer efficiency and the lack of accurate predictive tools for process...

Nodal Staging in Patients with Locally Advanced Non-Small Cell Lung Cancer: Indications, Approaches, and Impact on Downstream Treatment Selection

Locally advanced non-small cell lung cancer (NSCLC) is a biologically and clinically heterogeneous disease in which mediastinal lymph node involvement remains the principal prognostic and therapeutic discriminator. Accurate nodal staging guides selection among surgical resection,...

A clinical analysis of the presentation of depression in Pakistan

Background Major depressive disorder is a leading cause of disability worldwide, yet its clinical presentation varies substantially across cultural contexts. In many low- and middle-income settings, including Pakistan, depression is frequently expressed through somatic rather tha...

Associations of carboxypeptidase A1 and gamma-glutamyltransferase 1 genotypes with refractory functional dyspepsia: a potential link to pancreatic pathophysiology and refractory dyspepsia

Background and Aims This study aimed to investigate the associations between SNPs in CPA1, GGT1, and SPINK1 genes and the clinical characteristics of refractory FD including clinical symptoms, pancreatic enzyme abnormalities, and exocrine pancreatic function.Methods 97 Patients w...