Research works

Health expenditure and economic growth in post-Soviet Uzbekistan: ARDL evidence from a transition economy (2000–2022)

This study provides the first econometric examination of the health expenditure–economic growth nexus in Uzbekistan, Central Asia’s most populous economy, over 2000–2022. Using ARDL bounds testing, Granger and Toda–Yamamoto causality analysis, and endogenous structural-break test...

Life Cycle Greenhouse Gas Emissions of Water Hyacinth-Derived Biochar for Fuel and Soil Amendment Applications: Japanese Model Applied to Ethiopian Context

This study assesses life cycle greenhouse gas (GHG) emissions from water hyacinth (Pontederia crassipes; WH) biochar production and its subsequent use as fuel or soil amendment in Ethiopia. Overgrowth of WH in Lake Tana has created ecological and socioeconomic challenges, while t...

How Personal and Cognitive Traits Influence AI Attitudes, Ethics, and Well-being: The Role of AI Autonomy and Criticality in Design

Abstract As artificial intelligence (AI) systems become increasingly prevalent in decision-making, it’s essential to understand public perceptions in various contexts and cultures for responsible use. This study examines the relationship between acceptance and fear of AI, conside...

Compartmentalization of metals for photosynthesis and nitrogen fixation in specialized cells of the filamentous cyanobacterium Anabaena sp. PCC7120

Nitrogen fixing cyanobacteria, such as Anabaena sp. PCC7120, are some of the oldest multicellular organisms. When combined nitrogen sources are scarce, this cyanobacterium compartmentalizes photosynthesis and nitrogen fixation in vegetative cells and in differentiated heterocysts...

Spatial organization of the tumor-immune microenvironment in ER-positive breast cancer with treatment remodeling and associated clinical responses

The tumor microenvironment influences treatment response in ER-positive breast cancer, but what distinguishes responders from non-responders and how it changes during treatment is poorly understood. Here, we profiled ER-positive breast tumors treated with neoadjuvant chemotherapy...

Serum CC-Chemokine Profiling in Alcohol-Associated Liver Disease: Focus on MIP-3α/CCL20 as a Biomarker of Disease Severity

Background/Objectives: The inflammatory response is central to the pathogenesis of alcohol-associated liver disease (ALD), yet currently used prognostic scores, including Maddrey’s modified discriminant function (mDF), Child–Turcotte–Pugh (CTP), MELD-Na and MELD 3.0, reflect hepa...

Spin Purity andSpin Mixing in Lanthanide–CyclooctatetraeneComplexes: SO-MCQDPT2 and Axial-Field Analysis

Abstract Despite strong relativistic effects in organolanthanide systems, the origin and extent of spin-state mixing within the resulting electronic manifolds remain not fully resolved. In this article, we present a systematic analysis of Ln(COT) (Ln = Ce, Pr, Nd; COT = cycloocta...

N-Acetylcysteine, Tiron, and Their Combination: In Vitro Antioxidant and Anti-Inflammatory Activities and Their Protective Effect in a Rat Model of Acetic Acid-Induced Ulcerative Colitis

Ulcerative colitis is characterized by inflammation, oxidative stress, and excessive free radical production. This study investigated the antioxidant, anti-inflammatory, and protective effects of N-acetylcysteine (NAC), Tiron, and their fixed-ratio combination in acetic acid-indu...

Construction of an S-Scheme ZnIn2S4/C3N4 Heterostructure for Photocatalytic H2O2 Generation: Performance Evaluation and Mechanistic Insights

The global demand for hydrogen peroxide (H2O2) continues to increase, and photocatalytic H2O2 production is regarded as a promising alternative technology due to its mild, safe, and environmentally friendly characteristics. ZnIn2S4 has demonstrated promising application potential...

Clinical utility of molecular residual disease detection in early-stage resected EGFR-mutated non-small cell lung cancer

Molecular residual disease (MRD), detected through circulating tumor DNA, has emerged as a promising biomarker for surveillance in patients with early-stage non-small cell lung cancer (NSCLC) following curative-intent resection. Here we report the MRD analysis from the phase 3 EV...

Engineering Furcellaran/Xanthan Gum/Beeswax Composite Films Containing Spirulina via High-Shear Homogenisation: Structural and Physicochemical Properties

The growing demand for sustainable and functional packaging has driven the development of biopolymer-based films prepared from food-grade components with potential suitability for edible packaging applications. This study focused on the development and characterisation of furcell...

Participant-Independent Classification of Autism-Related Visual Attention Patterns from Eye-Tracking Scanpath Images Using a Global–Local Fusion Network

Children with autism spectrum disorder (ASD) often exhibit atypical patterns of visual attention allocation and social-cue processing. Eye-tracking scanpath (ETSP) retains information about fixation points, saccade paths and their temporal changes in the form of images, providing...

Unipolar Barrier Near‐Infrared 2D Photodetectors for 3D Image Sensors

ABSTRACT Photodetectors sensitive to the near‐infrared (NIR) range are of great importance for applications in machine vision, autonomous driving, and three‐dimensional (3D) imaging under low‐light or adverse weather conditions. Recently, two‐dimensional (2D) semiconductors have...

Protective Effects of Prenatal Bacopa monnieri Extract Against Valproic Acid-Induced Autism-like Behavioral and Neurohistological Alterations in Mice

Autism spectrum disorder (ASD) is a neurodevelopmental condition characterized by impaired social communication and repetitive behaviors. Oxidative stress is increasingly recognized as a key contributor to the neuro-degeneration and behavioral abnormalities associated with ASD. B...

Influence of System Dynamics on Vibration and Particle Emissions in a Reduced-Scale Dynamometer

Nonexhaust brake emissions represent a significant source of airborne particulate matter in urban environments. Although the effects of friction materials and braking conditions on particle generation have been extensively investigated, the role of friction-induced vibrations rem...

Greenhouse gas emissions of subsea telecommunications cables: A comparative study of trans-Atlantic and trans-Pacific systems

Subsea cables are critical for international data exchange. Yet lifecycle assessments (LCA) remain scarce, leaving a critical gap in understanding both the climate impacts of these systems and wider global telecommunications networks. Drawing on a unique model of industry collabo...

Teprotumumab in thyroid eye disease: Evidence, challenges, and the Indian perspective

ABSTRACT Thyroid eye disease (TED) represents a significant clinical burden in patients with Graves’ disease, with limited treatment options beyond glucocorticoids and conventional immunosuppression. Teprotumumab, a human monoclonal antibody targeting the insulin-like growth fact...

Curvature-induced asymmetric solidification in laser deposition of single-crystal superalloys: Multiphysics modeling and microstructural analysis

This study investigates the single-crystal epitaxial growth behavior of nickel-based single-crystal superalloys during curved-path laser-directed energy deposition using a thermo-fluid-solid coupled numerical model. The results reveal that the core mechanism underlying the curvat...

Surgical scene understanding and the structural validation gap in an industry-led AI ecosystem

This Matters Arising builds upon the review by Carstens et al. highlighting methodological limitations within the academic surgical scene understanding (SSU) literature. Increasingly clinically deployed SSU occurs within commercial platforms that are incompletely represented in t...

Optimizationof a Second-Generation, Highly SelectivePolθ/PARP1 Dual Inhibitor with Improved Pharmacokinetics andPotent Activity against HR-Deficient Tumors

Abstract Dual inhibition of Polθ and PARP1 represents a promising precision therapy strategy for HR-deficient tumors. While our first-generation Polθ/PARP1 dual inhibitor 4 provided proof-of-concept, its further development was hampered by poor selectivity over PARP2 and metaboli...