Research works

Durability of RSV Prefusion F Vaccine Protection across Two RSV Seasons

BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of hospitalization and death among older adults. Although first-season vaccine effectiveness against RSV-related hospitalization has been demonstrated for the bivalent RSV prefusion F protein-based vaccine (RSVpr...

Effect of Aficamten on Cardiac Structure and Function in Patients with Symptomatic Nonobstructive Hypertrophic Cardiomyopathy

BACKGROUND: Aficamten significantly improved both functional capacity and patient-reported health status in patients with symptomatic nonobstructive hypertrophic cardiomyopathy in the phase 3 randomized, placebo-controlled ACACIA-HCM trial (Assessment Comparing Aficamten to Place...

Burnout, Workplace Factors, and Retention Indicators Among Nurses in a Rural District Hospital in the Eastern Cape, South Africa

Background Burnout-related symptoms among nurses are a growing concern globally and may affect workforce well-being, patient care, and health system performance. In resource-constrained rural stableettings, heavy workloads, staffing shortages, and limited organisational support m...

Fast Breakdowns Observed in the Initial Leaders of Two Energetic Compact Strokes

Abstract We have observed 1 fast positive breakdown (FPB) and 20 fast negative breakdowns (FNBs) for the first time in the initial leader of two energetic compact strokes (ECSs) using a broadband interferometer. It was found that the FPB propagated upward over a distance of 30 m...

Unpacking interaction profiles and strategies in human-AI collaborative problem solving: a cognitive distribution and regulation perspective

This study adopts an integrated distributed cognition and regulation of learning perspective to examine the collaboration patterns and dynamics of human-AI interaction when college students collaborate with AI for complex problem-solving. Through cluster analysis, three distinct...

ACPC-MAP: a protocol for manually aligning structural T1-weighted magnetic resonance images to the anterior commissure – posterior commissure plane according to clinical standards

Abstract Realigning structural MR images to stereotactic AC-PC space is a standard procedure that enhances anatomical consistency both within and across neuroimaging studies, allowing for precise spatial localization and reliable cross-subject comparisons in both clinical and res...

Model-Based Learning of Whittle indices

We present BLINQ , a new model-based algorithm that learns the Whittle indices of an indexable, communicating and unichain Markov Decision Process (MDP). Our approach relies on building an empirical estimate of the MDP and then computing its Whittle indices using an extended vers...

Additive manufacturing of lunar regolith for reconfigurable building blocks toward lunar habitation

Utilizing locally available materials is a crucial step towards sustainable planetary habitation. Lunar regolith has gained tremendous interest in additive manufacturing in the past decades. However, due to the constrained manufacturing facilities and materials on the moon, many...

FastCNV: fast and accurate copy number variation prediction from high-definition spatial transcriptomics and scRNA-seq data

Abstract Background Predicting DNA copy number variations (CNVs) from spatial transcriptomics (ST), including Visium HD, or single-cell RNA-sequencing (scRNA-seq) data helps to distinguish malignant from non-malignant cells and to characterize the clonal architecture of tumor cel...

Cool Citizens? How Affectively Unpolarized Citizens View and Participate in Democracy

Abstract Does affective polarization change how citizens view and participate in democracy? We posit that the answer to this crucial question depends on how affectively un polarized citizens view and participate in democracy. Yet, the most common operationalization of affective p...

New iPSC resource with long-read whole genome sequencing characterizations for enhanced in vitro modeling

Abstract Here we present a new iPSC resource of apparently healthy subject biospecimens available to the research community through the National Institute of General Medical Sciences Human Genetic Cell Repository (NIGMS Repository). This resource includes five iPSCs and matched p...

The Molecular Architecture of Somatic Spines of the Lateral Septum

ABSTRACT The lateral septum is a key subcortical structure and has been implicated in social memory. One aspect of social memory, the ability to recognize relatives, is conserved across vertebrate species and reflected in stable, lifelong memories. Synapses are considered to be t...

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

Abstract Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Skin infection at the bite site represents a critical and conserved step in transmission and a deeper understanding of this process will p...

Unraveling single-molecule reactions via multiplexed in-situ DNA sequencing

Abstract DNA sequence regulates complex reactions and protein-DNA interactions, yet sequence effects remain poorly understood due to the lack of direct, high-throughput approaches to study sequence-dependence at the single-molecule level. Here, we introduce Single-molecule Phenot...

Photon trapping in a time cavity flying at the speed of light

Abstract A refractive index step, moving at the speed of light, can serve as a trap for weak light waves. Here we shed light on highly unusual features of such trapping, making it fundamentally different from conventional “resting” cavities. First, such trapping can be described...

When Adaptivity Counts: Hit-Count Inspection with Information-Only Queries

We study a hidden-set problem in which perfect point queries acquire information but earn no reward, while a separate exact-q terminal action earns its hit count. Every instance satisfies V_ad^# <= q V_batch^#; taking the supremum over all depths and finite positive-batch instanc...

Formal Mathematical Translation of the Empathic Logic Model

This extension of ELM presents the formal mathematical translation of the Empathic Logic Model (ELM). Because foundational psychological mechanisms and narrative elements function as qualitative components, all related constructs are designated as such; for comprehensive qualitat...

Cross-Round Aggregation in Interactive Whole-Body PET/CT Lesion Segmentation: a Training-Free Study Alongside a Baseline Submission to autoPET V

autoPET V scores interactive whole-body PET/CT lesion segmentationby the area under the Dice-versus-interaction-round curve, so thetrajectory across rounds matters as much as the final state. Wesubmit the organisers’ nnU-Net interactive baseline withoutmodification, and report al...

Where Are the Cracks in the Definition of "Cracked Concrete"? A Critical Review of the Normative Basis for the Cracked-Concrete Default in Post-Installed Anchor Design, and the Case for a Probabilistic Classification

EN 1992-4 permits a fastening to be designed for uncracked concrete only where the absence of cracking can be demonstrated over the whole anchorage depth; in the absence of that demonstration the concrete is taken as cracked. In practice the demonstration is rarely attempted, and...

Apparent Dark Halos as Residual Geometry from the Complete Virial Theorem

What if the apparent dark halo is neither an unobserved mass component nor an ad hoc modified force law, but the radial structure of a bounded gravitational residual slope? Derived from the non-stationary term of the complete scalar Virial Theorem ($\frac{1}{2}\ddot{I} = 2K + W$)...