Research works

TRIM22 promotes K48-linked ubiquitination of LDHA, leading to the inhibition of HBV replication

Hepatitis B virus (HBV) infection and its related liver diseases remain a major worldwide public health problem, its mechanism hasn't fully clarified. While our previous work identified TRIM22 as an interferon-stimulated gene that suppresses HBV replication via innate immune path...

Oropouche virus causes severe congenital disease in embryonic mice

Abstract The recent outbreak of Oropouche virus (OROV) in Latin-America with unprecedented reports of vertical transmission resulting in congenital malformations and fetal death, redefines the threat posed by this arbovirus. We discovered that injection of a low inoculum of the e...

Intrinsic volumes of the quantum state space and mutually unbiased bases

Abstract Previous studies on the geometrical properties of the state space of a finite-level quantum system have determined its volume and surface area. Building on this foundation, we derive explicit formulas for two additional intrinsic volume quantities. The question of whethe...

The Association Between Victims’ Anxious Attachment and Transgressors’ Nonapology on Conflict Resolution in Romantic Relationships

Managing conflict is integral to romantic relationships. When a romantic partner transgresses against the other partner, a victim’s response may be motivated by their attachment style and their partner’s post-transgression responses (PTRs). In the current research, we tested whet...

Impact of respiratory syncytial virus immunization in older adults: the importance of a valid burden estimation

ABSTRACT Introduction In the province of Québec, Canada, a respiratory syncytial virus (RSV) immunization program restricted to seniors residing in long-term care facilities (LTCF) and those aged ≥75 years from private senior residences (PSR) was implemented in Fall 2024, with ap...

Confidence Revisited: The Distribution of Information

Classical statistics assesses the confidence of a prediction by measuring error variance, estimation variance, or the sum of both. More complex machine learning models assess confidence using empirical methods such as resampling or conformal prediction. Model-based assessments of...

Classifications of Substorms With MLT Patterns of SMU‐SML Indices Based on Convection Properties

Abstract During substorms, magnetospheric convection and magnetotail current sheet disturbances are two critical processes, both driving ionospheric electrojets. Dusk‐side SMU and dawn‐side SML (SuperMAG Electrojet indices) enhancements reflect two‐cell convection. Using this rel...

A Limit Theorem for Certain Feller Semigroups, and the Distribution of the Local Time for Brownian Motion When it Exits an Interval

Within the framework of the theory of semigroups of operators, we consider a local singular perturbation of a one-dimensional Laplace operator. The Feller semigroups we study describe Brownian motions on an interval with killing that is more and more concentrated around a chosen...

Tailoring cellular automata for physically-based generation of periodic microstructures in powder bed fusion processes

Abstract Accurate representation of periodic microstructures is essential for predicting faster the effective mechanical response of additively manufactured metals through computational homogenization. While geometrically-based microstructure generation approaches can readily enf...

NAD+ precursor treatment prevents cardiomyopathy but disrupts erythroid maturation in mitochondrial progeria

Summary Nicotinamide adenine dinucleotide (NAD + ) plays a central role in energy metabolism, and its decline is linked to various degenerative diseases. While NAD + restoration holds therapeutic promise, its long term, tissue-specific consequences remain poorly understood. We in...

Stringy Constraints on Modular Flavor Models

Abstract We investigate stringy constraints on moduli spaces in modular flavor models by analyzing moduli-dependent threshold corrections in heterotic string vacua. While moduli play a crucial role in determining the flavor structure of fermions predicted by modular flavor models...

Wind‐Driven Circulation Feedbacks Offset Tropical Geoengineered Sea Salt Emissions

Abstract Using a NOAA Geophysical Fluid Dynamics Laboratory coupled atmosphere–ocean (CM4) comprehensive model, we employ simulations of enhanced, geoengineered sea salt aerosol (SSA) emissions in the tropics to examine the circulation response to idealized marine cloud brighteni...

Millimeter-wave directed energy-mediated neural cell injury: insights into protein degradation and cell injury mechanisms

Background: Millimeter-wave directed energy (mmWave DE) is increasingly used in telecommunications and military applications, yet its biological effects on neuronal systems remain unclear. To characterize the spatially dependent cellular and molecular impacts of 34.14 GHz mmWave...

Contribution to the knowledge of the distribution of bats (Chiroptera) in Algeria

Algeria is the largest country in Africa and for the most part has not yet been surveyed for bat species. To contribute to the knowledge of the distribution of Algerian bat fauna, between 2011 and 2026 we surveyed 70 sites from 19 provinces across the country, mostly roost sites...

No Easy Fix to Countering AI-Generated Visual Disinformation: The (in)Effectiveness of AI-Labels, Fact-Check Labels and Community Notes

As generative AI makes it easier to create synthetic visuals, AI-driven visual disinformation isbecoming more common on social media. However, while much research highlights its potentialharm, less is known about how to reduce its potential to mislead. In this study, we therefore...

Why do some tourists litter while others don't? Exploring the role of awareness, commitment, and attachment among tourists in Bali

The rapid growth of tourism in Bali has contributed to significant environmental challenges, especially the rise in waste produced by tourist activities. Improper waste disposal threatens destination sustainability and demands behavioral change among visitors. This study explores...

Persistent chromatin alterations and gene expression reprogramming follow widespread DNA damage in glioblastoma

Abstract DNA damage from routine cellular processes or exogenous insults can have a lasting impact on gene regulation beyond genetic mutations. The prevailing paradigm for the consequences of DNA damage repair revolves around restoration of the original genetic sequence, but long...

Optimizing wollastonite treatment to enhance sustainability and reduce carbon emissions in cement-based materials

The sustainable use of natural minerals in construction materials is vital for minimizing the cement industry's environmental impact. Wollastonite, a calcium silicate mineral, offers significant potential as a supplementary cementitious material to reduce carbon emissions and enh...

New evidence on the 1919 FA silver cup: a forgotten chapter in Japanese football history

The Japan Football Association (JFA) was founded in 1921, following the donation of a silver cup by the Football Association (FA) in 1919. This trophy became the centerpiece of a tournament that later evolved into the prestigious Emperor's Cup. While the conventional narrative at...

Designing Tendon and Reinforcement Configurations for Punching and Postpunching Performance Demands of Posttensioned Concrete Flat Plate Slab–Column Joints

Abstract The punching shear and postpunching strengths of slab–column joints (SCJs) are the critical indicators of the resistance of posttensioned concrete flat plate structures to progressive collapse. These two capacities, however, are governed by distinct failure mechanisms an...