Research works

Climate classification, sociodemographic development, and the burden of inflammatory bowel disease in tropical countries

Geographic definitions of the tropics may obscure substantial climatic heterogeneity. Climate classification provides a more ecologically meaningful framework for evaluating inflammatory bowel disease (IBD) in tropical settings. However, few studies have examined tropical IBD bur...

Binclean: Sanitizing Disassemblies to Improve Malware Recognition

Malware is malicious software that compromises data and computer systems. In 2024, the Internet Crime Complaint Center (IC3) reported $12.47 million in ransomware losses alone, highlighting the escalating severity of cyber threats. Because source code is rarely available, analyst...

Association of socioeconomic status on parental knowledge, attitudes, and practices regarding dental fluorosis in Salem, Tamil Nadu: a cross-sectional study

Dental fluorosis is a significant public health burden in endemic regions like Salem, Tamil Nadu. While environmental fluoride levels are the primary cause, the severity of the condition is often mediated by parental awareness and preventive practices. Socioeconomic status (SES)...

Femtosecond laser modification of LPCVD-SiN photonic devices: microstructural evolution and post-fabrication trimming

Femtosecond laser processing provides a localized and contactless approach for permanent post-fabrication trimming of integrated photonic devices. Here, we investigate dose-dependent microstructural evolution in low-pressure chemical vapor deposition silicon nitride (LPCVD-SiN) a...

New-onset and persistent suicidal ideation and non-suicidal self-injury among Chinese university students: A one-year longitudinal study

Suicidal ideation (SI) and non-suicidal self-injury (NSSI) are clinically important mental health concerns among university students, yet longitudinal evidence distinguishing new-onset and persistent patterns remains limited. This one-year longitudinal study examined changes in S...

Autoimmune pernicious anemia in clinically diagnosed Bardet–Biedl syndrome: a case report and brief literature review

Bardet–Biedl syndrome is a rare autosomal recessive ciliopathy that may be diagnosed clinically in resource-limited settings where molecular testing is unavailable. Autoimmune pernicious anemia has been rarely described in association with BBS, and its relationship to BBS-related...

Construction and validation of a diagnostic model for interventricular septal hypertrophy based on electrocardiographic parameters and clinical factors

Interventricular septal hypertrophy (IVSH) is considered to be an early-stage alteration of left ventricular hypertrophy and is a major risk factor for a wide range of fatal arrhythmias and heart failure. We aimed to develop and validate a diagnostic model to detect patients with...

Evaluating the association between emotional intelligence, perceived support, and academic performance among nursing graduate students: a descriptive-correlational study

Nursing graduate education in Pakistan is increasingly recognized as pivotal for producing competent clinical leaders, educators, and researchers. However, the rigorous academic and clinical demands place immense psychological pressure on students, potentially compromising their...

Beyond resistance: an integrated psychological organizational model of employee response to digital transformation

Organizational competitiveness increasingly depends on successful digital transformation, yet employee resistance remains a critical barrier. This study develops an integrated framework grounded in Innovation Resistance Theory and Social Cognitive Theory to investigate key driver...

Racial discrimination and healthcare disparities in sickle cell disease: An integrative review

Sickle cell disease is an inherited genetic disorder that predominantly affects the Black population and can lead to serious complications like stroke and acute chest syndrome, significantly compromising the quality of life of those affected. An integrative literature review was...

Dissecting a novel Fusarium head blight resistance QTL TaFhb-6A in wheat Line R111 using integrated multi-omics strategies

Fusarium head blight (FHB) is a devastating fungal disease that threatens wheat yield and quality worldwide. Breeding FHB-resistant cultivars is the most sustainable solution, whereas the narrow genetic basis of resistance has restricted breeding progress. In this study, we devel...

Cardiovascular disease as a driver of tumor development: epidemiological, mechanistic and bioinformatic insights

In recent years, the field of Cardio-Oncology has expanded beyond its traditional focus on cancer therapy–related cardiotoxicity. Growing evidence now supports a bidirectional relationship between cardiovascular disease (CVD) and cancer, in which CVD may promote tumor progression...

Agreeableness and self-reported bullying-related perpetration behaviors among health-professions undergraduates in the United Arab Emirates: a cross-sectional study

Bullying and peer mistreatment in health-professions education may undermine psychological safety, wellbeing, and professional learning. This study examined the association between agreeableness and self-reported bullying-related perpetration behaviors among health-professions un...

The Circadian Skin: Chronobiology as a New Frontier in Dermatological Therapy

The skin is a temporally dynamic organ governed by intrinsic molecular clocks operating across multiple cell types. Circadian regulation influences epidermal renewal, barrier function, pigmentation, immune activity, DNA damage responses, and wound repair. This narrative review cr...

A firefly-inspired model for detecting the alien

The Search for Extraterrestrial Intelligence (SETI) has historically been a search for aliens like us, shaped by human-centric ideas of intelligence, communication, and technology. However, humans are not the only instance of an intelligent, communicating species on Earth, and th...

Integrating waste heat and biomass energy in a three-entropy state framework optimized by emergy-carbon-neural network for sustainable buildings

This study addresses the urgent need for low-carbon transformation in the construction sector by proposing a novel building energy supply system that integrates industrial waste heat and biomass energy to tackle the issues of low energy efficiency and high carbon emissions in tra...

A broadly applicable somatic embryogenesis platform accelerates regeneration and genetic transformation in elite alfalfa

Alfalfa ( Medicago sativa L. ) is a globally important perennial forage crop, but molecular breeding is constrained by slow, genotype-dependent regeneration and transformation. This bottleneck is particularly pronounced in elite commercial cultivars, for which efficient protocols...

Cholesterol sulfate as a novel theranostic target for sepsis-induced liver injury through Beclin1-mediated autophagy enhancement and pyroptosis suppression

Sepsis remains a life-threatening syndrome, and septic liver injury is a frequent and critical complication for which no specific pharmacological therapy exists. Current biomarkers lack sufficient specificity for early diagnosis and severity assessment, highlighting an urgent nee...

Global pandemic preparedness before and during COVID-19: an assessment of changes and financing

COVID-19 exposed weaknesses in health-system readiness and renewed interest in how reported preparedness changed across countries. This paper describes changes in formal preparedness capacity before and during the pandemic, presents health-expenditure and pandemic-response accoun...

TGF-β3 derived from CD8+ T cells plays an important role in the lungs of piglets infected with SIV

The swine is considered an important host for the production of pandemic influenza viruses, and studying the immune characteristics of swine influenza virus (SIV) infection in piglets is crucial for pandemic prevention. Here, we used single-cell sequencing (scRNA-seq) to demonstr...