Research works

Antifibrotic therapy in patients with pleuroparenchymal fibroelastosis: a multicentric observational study

Pleuroparenchymal fibroelastosis (PPFE) is a rare interstitial lung disease characterized by upper-lobe predominant pleural and subpleural fibrosis and associated with poor prognosis. No evidence-based medical therapy is currently established, and lung transplantation remains the...

Uncovering the psychological mechanisms behind quarter-life crisis and suicide cognitions

Young adults may experience a quarter-life crisis due to challenges they face in education, work, and relationships. Individuals experiencing a quarter-life crisis face numerous mental health issues, including psychological distress, entrapment, hopelessness, and suicidal ideatio...

Comparative study on the effects of 2D and 3D cell culture on the functions of stem cells from the apical papilla

Dental-derived stem cells (DSCs), especially stem cells from the apical papilla (SCAP), are vital for regenerative medicine. Three-dimensional (3D) cell culture is superior to two-dimensional (2D) culture in mimicking in vivo environments. A dynamic 3D culture system consisting o...

Cross-modal processing of auditory and visual symbol representations in the temporo-parietal cortex

Numeracy and literacy are fundamental cognitive skills that rely on associating visual symbols with their spoken representations. Prior research has identified the posterior temporal-parietal cortex as a key neural region for the cross-modal transformation of these audio-visual a...

Portable X-ray fluorescence spectrometry library for Brazilian soils: chemical characterization and prediction of soil particle size fractions across all biomes

Sensor-based soil data libraries have proven valuable for a wide range of applications. Given the increasing adoption of portable X-ray fluorescence (pXRF) spectroscopy for soil-related studies, we aimed to create a library of soils characterized by pXRF and develop prediction mo...

Construction of a federated learning-based privacy-preserving and intelligent recommendation model for educational data

With the development of the advanced educational platform, more and more personalized recommendation systems are used to increase the efficiency of learning and make the dissemination of the educational resources easier. However, educational recommendation tasks involve highly se...

Epidemiology and clinical characteristics of pediatric foreign body aspiration in sub-Saharan Africa: a systematic review and meta-analysis

Foreign body aspiration (FBA) is a significant cause of accidental death in children under three years worldwide and is perhaps the most time-sensitive emergency in pediatric medicine. While high-income countries have established surveillance systems, the burden and characteristi...

Tumor border delineation in basal cell carcinoma using Fourier analysis

Basal cell carcinoma (BCC) is the most common malignancy in Caucasians. Surgical excision is the gold standard for treating BCC; however, poorly defined borders often challenge complete removal. Therefore, there is a need for efficient imaging techniques to enable visual and quan...

Mapping changes in ecosystem wealth associated with cities expansion: the case of 9 Asian countries

Urban expansion is an important driver of environmental change, leading to land-cover conversion and changes in ecosystem wealth. While previous studies have assessed the national effects of urbanization on ecosystems, few have attributed these effects to specific cities based on...

Single-phase fault diagnosis in distribution networks via cyber-secure hybrid models of artificial intelligence

Ensuring stability and cyber-security in modern distribution networks is critical for the reliable operation of smart grids. This study proposes a hybrid artificial intelligence model that integrates an Autoencoder (AE) for feature compression and denoising, a Convolutional Neura...

Oral Nano-vaccines for cancer immunotherapy: mechanisms, barriers, and the oral-GALT-tumor immune axis

Oral nano-vaccines offer a non-invasive approach for cancer immunotherapy by combining gastrointestinal delivery with mucosal immune induction and systemic antitumor immune activation. However, their development remains constrained by antigen degradation in the gastrointestinal t...

Acute oncology for foundation doctors: evaluating an educational intervention

Foundation doctors work in varying settings across general practice and hospitals, often interacting with oncology patients. It is vital these doctors take comprehensive histories and understand how to use the acute oncology service (AOS), to optimise patient care. Currently, the...

Outcomes of patients with adult T-cell leukemia/lymphoma at a university and a public cancer center in Brazil

OBJECTIVE: This study aimed to characterize adult T-cell leukemia/lymphoma (ATLL) cases in Brazil, a human T-cell lymphotropic virus type 1 (HTLV-1) endemic country, focusing on clinical presentation, diagnostic patterns, and prognostic factors, in order to address potential unde...

Integrative transcriptomic and metabolomic analysis reveals resistance mechanisms of Dendrocalamus brandisii shoots against Cyrtotrachelus buqueti herbivory

Dendrocalamus brandisii Kurz. is a high-quality bamboo species suitable for timber and bamboo shoot production. However, during its growth, this species is susceptible to infestation by Cyrtotrachelus buqueti Guer, which leads to a decline in bamboo yield and quality, resulting i...

NFS1 activates PI3K/AKT/mTOR signaling to upregulate GPX4 expression and enhance ferroptosis resistance in osteosarcoma

Osteosarcoma continues to exhibit poor survival outcomes due to chemoresistance and metastasis, with metabolic reprogramming and ferroptosis resistance being key features of tumor heterogeneity, yet their upstream regulators remain poorly defined. NFS1, a cysteine desulfurase ess...

Ibrutinib therapy results in atrial fibrillation through modulation of the Src-Erk1/2 pathway

The Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib has revolutionized treatment for B-cell malignancies but increases the incidence of atrial fibrillation (AF) compared to conventional chemotherapy. The downstream signaling pathways through which ibrutinib leads to AF are unk...

Quantitative image feature integrated digital pathology model based on deep learning and machine learning for binary histological severity stratification of ulcerative colitis

The STRIDE II consensus recognizes histopathological healing in ulcerative colitis as a key therapeutic target. This study aimed to develop and internally evaluate a quantitative image-based model for the binary classification of mild versus moderate-to-severe UC based on histopa...

Effects of maize straw-derived biochar on soil nutrient dynamics and nematode community structure in upland yellow soil

Biochar, a carbon-rich soil amendment, has considerable potential to enhance soil fertility, promote carbon sequestration, mitigate greenhouse gas emissions, and support sustainable agricultural development. However, in upland acidic yellow soil regions, the responses of soil nem...

Suspended patient-specific instrument-assisted femur-first osteotomy for fixed-bearing unicompartmental knee arthroplasty: technical note and preliminary clinical results

This study designed a novel suspended patient-specific instrument (SPSI), described its design rationale and the surgical workflow of femur-first osteotomy based on this instrument, and explored its feasibility and early clinical outcomes in fixed-bearing unicompartmental knee ar...

Prioritizing dental care in South Korean prisons: a dual-structured triage model integrating medical urgency and willingness to pay

Dental care in correctional institutions is often constrained by limited resources, raising concerns about treatment prioritization. This study explores how prison health dentists (PHDs) allocate dental treatments based on clinical urgency and inmates' willingness to pay (WTP), a...