Research works

Manufacturing trueness, internal fit, and planned-to-intraoral spatial concordance of monolithic zirconia crowns fabricated with two commercial ti-base systems: a clinical cross-sectional study

Abstract Objectives The aim of this clinical cross-sectional study was to evaluate manufacturing trueness, internal fit, planned-to-intraoral spatial concordance, and proximal contact discrepancy in implant-supported monolithic zirconia crowns fabricated within two commercial ti-...

Effect of BMI on efficacy of androgen receptor pathway inhibitors in patients with metastatic hormone-sensitive prostate cancer

Background Body mass index (BMI) has been associated with improved outcomes in several malignancies, including prostate cancer. However, the impact of BMI on treatment efficacy, particularly with androgen receptor pathway inhibitors (ARPIs), in metastatic hormone-sensitive prosta...

Gut microbiota-derived acetate mitigates Escherichia fergusonii-induced gut dysbiosis exacerbating Klebsiella pneumoniae pulmonary infection in mice

Escherichia fergusonii is an emerging food-borne opportunistic pathogen that disrupts gut homeostasis and exacerbates the severity of other organ diseases. However, the effects of gut colonization by E. fergusonii on the gut-lung axis remain unclear. Here we show that the abundan...

Ensemble Machine Learning Predicts Flooding- and Organic Matter-Induced Micronutrient Dynamics in Calcareous Soils

Flooding and farmyard manure (FYM) application trigger complex, non-linear redox reactions that govern micronutrient availability in calcareous soils, yet predictive modelling of these dynamics using machine learning (ML) remains largely unexplored, and the present study was desi...

Kambô: as DIY frog toxin kits are sold in the UK, what is the evidence and what are the risks?

<i>A South American shamanic ritual is rapidly gaining popularity, with DIY kits becoming available for self-administration</i>

Experimental Investigation of Electrical Parameter Effects in Wire Arc Atomization of 316L Stainless Steel Powders for Additive Manufacturing

Conventional industrial‐scale production of metal powders generally occurs in large plants, where each batch sizes several hundred kilograms of powder. However, these production methods are economically impractical for manufacturers with lower demands, such as those involved in p...

Sex Work and Policing in the United States

Prior research on sex worker–police interactions in the United States has primarily focused on regional samples and negative interactions. The current study draws from national sex worker survey data ( N = 440) and seeks to answer two questions: (1) What types of interactions do...

Unraveling the Micromechanisms of Plastic Synergy in TWIP Steel With a Multigradient Structure

Gradient structural design offers a novel and effective strategy to overcome the long‐standing strength‐ductility trade‐off in metallic materials. In the present study, to address the low yield strength of conventional twinning induced plasticity (TWIP) steel, a multigradient str...

Economic and social modulations of innate decision-making in mice exposed to visual threats

When confronted by predators, animals make innate decisions with rapid reaction times—a trait shaped by natural selection to maximize survival. However, rapid reactions are effective only when grounded in accurate judgments and appropriate choices, which often require cognitive c...

The Global Descent Principle:A Comprehensive Structural Framework for the Collatz Conjecture With Complete Proofs, Extensive Numerical Verification, and Honest Analysis of Open Problems

This paper introduces the Global Descent Principle (GDP), a comprehensive structural framework for the Collatz (3x+1) conjecture. The framework provides:- A complete mod 8 classification of Syracuse iterates- Exact algebraic formulas for pure weak descent substructures - A core e...

Statistical‐ CSI ‐Aware Secrecy Energy Efficiency Maximization in Dual‐ RIS Networks With Mobile Eavesdropper

ABSTRACT In this paper, the secrecy energy efficiency (SEE) maximization problem is investigated in a dual‐reconfigurable intelligent surface (RIS)‐assisted downlink multiple‐input single‐output (MISO) system with an intermittently active mobile eavesdropper under statistical cha...

The Made‐in‐Africa Evaluation framework: A decolonial approach to program evaluation

Abstract The Made in Africa Evaluation (MAE) framework is a decolonial approach to program evaluation developed by African evaluators over the past 14 years. MAE may be appropriate to community psychologists who practice program evaluation or conduct research in Africa, but littl...

The Big Stretch: Regulated Accumulation Beyond the Big Stretch

Contemporary cosmology is confronted by a growing collection of unresolved tensions, including discrepancies in measurements of the Hubble constant, anomalies in large-scale variance distributions, questions surrounding dark energy evolution, and the persistent challenge of recon...

A Validated Macro‐Scale CFD Thermal Framework for a Temperature‐Controlled Coffee Fermentation Bioreactor: Integrated Heat‐Transfer Simulation and Experimental Analysis

ABSTRACT Temperature exerts a critical influence upon coffee fermentation, driving microbial metabolic pathways, acidification kinetics, and post‐harvest bean quality. This study presents an integrated computational fluid dynamics (CFD)–experimental validation framework to analyz...

Fiber optic-based magnetostrictive sensor for monitoring pipe wall thickness

This article presents a novel sensor concept for continuous long-term monitoring of pipe or tank wall thickness that is based on strain measurements in a magnetostrictive material. The proposed sensor detects wall thinning in pipes or tanks by monitoring magnetic flux leakage (MF...

Environmental DNA Metabarcoding Reveals the Variations in Fish Diversity Across the Yangtze River Basin and the Effects of the Three Gorges Dam

It is imperative that freshwater fish biodiversity research incorporates diverse components, encompassing taxonomy, phylogeny and function, alongside multifaceted facets, including richness, divergence and regularity. This comprehensive approach is essential to facilitate a more...

Clinicopathological characterization and prognostic significance of HER2-low expression in endometrial cancer: a ProMisE molecular classification-based analysis

Antibody–drug conjugates have renewed interest in tumors with low-level HER2 expression. However, the clinicopathological distribution and prognostic significance of HER2-low status in endometrial cancer, particularly across ProMisE molecular subtypes, remain uncertain. This sing...

Experimental Investigation of Mechanical Properties of 3D-Printed Components Fabricated from Waste Plastic Extruded Filaments

Abstract The exponential global growth of post-consumer plastic waste poses severe environmental and socio-ecological challenges, necessitating innovative, decentralized recycling strategies. Simultaneously, the rapid industrial and domestic proliferation of Fused Deposition Mode...

Clinical Application of Circulating Tumor DNA in Surgically Treated Esophageal Squamous Cell Carcinoma

Background: Esophageal squamous cell carcinoma (ESCC) is associated with a high recurrence rate and is one of the most aggressive malignancies. Recurrence is mainly detected via imaging modalities; however, postoperative imaging surveillance has disadvantages, including reduced s...

MTAP deficiency in lung cancer cells enhances proliferation and migration and increases vulnerability to bone metastasis

Lung cancer continues to be the leading cause of cancer-related death worldwide. The advent of molecular targeted therapies has significantly changed the treatment landscape. Therefore, identifying new molecular targets is essential for the development of more effective treatment...