Research works

Age-modified shock index for predicting in-hospital outcomes in patients with ST elevated myocardial infarction undergoing primary percutaneous coronary intervention

Early risk stratification in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI) is crucial for timely identification of high-risk patients. Bedside indices derived from routinely available hemodynamic param...

Evaluation of sirtuin 1 serum level and gene expression in patients with metabolic syndrome accompanied by metabolic dysfunction-associated steatotic liver disease

Abstract Background Metabolic syndrome is a cluster of conditions, including abdominal obesity, dyslipidemia, hypertension, and impaired glucose metabolism, that significantly increase the risk of cardiovascular disease and type 2 diabetes mellitus (T2DM). Metabolic dysfunction-a...

Spatiotemporal properties in cognitive map formation: context-dependent effects of landmarks and perspective

Abstract Effective navigation depends on the formation of cognitive maps, yet it remains unclear how temporal experience is integrated with spatial information during this process. While prior research has primarily emphasized external spatial cues, real-world navigation unfolds...

Straightforward Assessment of Structural Disorder in Ti3C2T x MXene Using Raman Spectroscopy: Implications for Defect Engineering

Abstract MXenes, a large family of two-dimensional transition-metal carbides and nitrides, have attracted considerable interest owing to their unique physicochemical properties. Structural defects play a key role in tuning these properties, yet their characterization remains high...

Bronchopneumonia With Cutaneous Vasculitis: A Diagnostic Challenge

Bronchopneumonia associated with atypical cutaneous manifestations poses a significant diagnostic challenge because of the broad spectrum of infectious, inflammatory, autoimmune, and vasculitic disorders that may present with overlapping clinical features. Careful clinicopatholog...

ZMIZ1 promotes aerobic glycolysis and development of hepatocellular carcinoma through inducing NOTCH1-mediated transcription of PYCR1

Hepatocellular carcinoma (HCC) is characterized by profound metabolic reprogramming that promotes tumor progression. Although zinc finger MIZ-type containing 1 (ZMIZ1) has been implicated in several malignancies, its biological function and underlying mechanism in HCC remain uncl...

YouTube Explainers of Unsolved Math Problems: Pedagogical Overviews of Known Conjectures — E8 Intelligence Research

FINDING: Compilation of unsolved math problems presented in popular YouTube explainers, primarily targeting broad public understanding rather than new research. | MATH: No new equations or constants extracted; content is pedagogical, referencing known open problems (e.g., Collatz...

Preliminary Evaluation of Cytotoxic and Metabolic Modulatory Activities of Mentha cordifolia Opiz Leaf Crude Extract on Human Peripheral Blood Mononuclear Cells

Mentha cordifolia Opiz (yerba buena) is traditionally used for its antimicrobial and therapeutic properties. The cytotoxic and metabolic modulatory effects of the buffered leaf crude extract of M. cordifolia Opiz on human peripheral blood mononuclear cells (PBMCs) were evaluated...

Boundaries Between Freedom of Expression and Hate Speech: The Case of Struggle Songs Current Perspectives From the Global South

This discussion article addresses the historical, political and social context of struggle songs in South Africa and the circumstances in which such songs should be considered prohibited hate speech. The analysis is framed around the decision in AfriForum v Malema , in which the...

Impact of chronic doxycycline treatment in a mouse model of tauopathy

Tauopathies are neurodegenerative disorders characterized by the accumulation of hyperphosphorylated tau, leading to synaptic dysfunction, neuroinflammation, and both cognitive and motor impairments. Doxycycline (Doxy), a tetracycline antibiotic commonly used to treat bacterial i...

Latent profiles of perceived digital convenience and their associations with depressive symptoms among Chinese empty-nest older adults: evidence from the 2023 CLASS

Digital technology is increasingly discussed as a potential resource for supporting mental health in later life, yet empirical findings remain mixed. Prior studies have largely relied on variable-centered approaches that may obscure how perceived convenience of digital activities...

Personality and emotional stability in dogs assessed for animal-assisted services: Exploratory findings from APWA-ICofA

Abstract Background : Dogs working in animal-assisted services (AAS) must be emotionally stable, socially appropriate, and able to cope with diverse and potentially demanding environments. However, standardized, welfare-centered tools for evaluating canine suitability remain limi...

The Axiom of Mind: An Open Letter to Professor Koch on Semantic Plasticity, Agency, and the Great Triad (Parts III–IV)

This publication represents the second installment (Parts III–IV) of the open philosophical and scientific inquiry addressed to neuroscientist Christof Koch, expanding upon the "Axiom of Mind" formulated by Vladislav Stukalov: "The Mind is not solely biological. It is a computati...

Stepwise stabilization of low-melting constituents enables grain refinement and overburning suppression in highly alloyed Al–Zn–Mg–Cu alloys

High-strength Al–Zn–Mg–Cu alloys require high-temperature solution treatment to increase solute supersaturation, but severe Zn/Mg/Cu segregation and low-melting eutectic constituents make them highly vulnerable to overburning. Here, a multi-stage solution treatment (MST: 450/2h +...

MODEL ADOPTION #1110: REJECT — LEDGER BENCH: Apply filter: USDCHF SHORT — improves win rate from 31.7% to 61.2% (+29.5pp, — E8 Intelligence Research

DECISION: REJECT ELEMENT: The filter "block all USDCHF SHORT trades" is a blunt instrument that contradicts E8 geometry timing, which relies on polarity edges, not static pair-direction bans. The backtest (n=165) is too small and likely period-fitted; the same-window effect alrea...

Television Health Talk Shows as a Media for Health Literacy for Stroke Survivors

This study examines television health talk shows as a medium for strengthening health literacy among stroke survivors, with particular attention to understanding, motivation, and adaptation to healthy lifestyles. Using a descriptive qualitative design, the study involved ten stro...

Direct Graft Copolymerization of Cellulose Acetate Membrane with Bio-Based Itaconic Acid for Pollutant Removal from Wastewater

Cellulose acetate (CA) is a promising bio-derived membrane material for water treatment; however, its limited availability of active functional sites can restrict its affinity toward dissolved pollutants. In this study, a cellulose acetate membrane was fabricated by phase inversi...

Comparative evaluation of mechanical properties of directly 3D-printed clear aligner materials

Objectives: This study comparatively evaluated the mechanical properties of four commercially available, directly three-dimensional (3D) printed clear aligner materials by analyzing tensile behavior, flexural properties, and surface hardness. Material and Methods: Four direct-pri...

Chitin‐Derived Carbon‐Metal Functional Materials

ABSTRACT Biomass‐derived carbon materials have emerged as sustainable alternatives to petroleum‐derived adsorbents for environmental remediation applications. Among biomass feedstocks, chitin offers advantages due to its abundance as seafood‐processing waste and its intrinsic nit...

The association between depression and frozen shoulder: A systematic review and meta-analysis

BackgroundFrozen shoulder (FS), commonly known as adhesive capsulitis, is a disabling musculoskeletal condition frequently accompanied by psychological distress. This meta-analysis aimed to evaluate the association between FS and depression.MethodsFor this meta-analysis, a system...