Research works

Therapeutic Plasma Exchange in Neuromyelitis Optica Spectrum Disorder: Real‐World Clinical Outcomes and Safety From a Tertiary Care Center in Northwest India

BACKGROUND AND OBJECTIVES: Neuromyelitis Optica Spectrum Disorder (NMOSD) is a severe autoimmune demyelinating disorder of the central nervous system characterized by relapsing attacks that can result in permanent neurological disability. Therapeutic Plasma Exchange (TPE) is reco...

The genome sequence of Quercus ilex L., 1753 (Fagales: Fagaceae)

<ns5:p> We present a genome assembly of <ns5:italic>Quercus ilex</ns5:italic> (holly oak; Streptophyta; Magnoliopsida; Fagales; Fagaceae). The assembly consists of two haplotypes with total lengths of 847.45 megabases and megabases. Most of haplotype 1 (99.65%) is scaffolded into...

IL-6 signaling drives treg dysfunction and pathogenic Th1-like polarization in major depressive disorder

Major depressive disorder (MDD) is pathologically associated with inflammatory-immune dysregulation. While regulatory T cells (Tregs) are essential for immune homeostasis, clinical evidence have reported paradoxical dynamics (deficiency vs. expansion) of peripheral Tregs in MDD p...

Sulforaphane Decreases the Burden of AKT1-Expressing Pre-Neoplastic Cells in a Zebrafish Model of Glioblastoma Initiation

Background: Glioblastoma is a primary aggressive brain tumor, with an average survival rate of ~14.6 months. The low therapeutic benefit of current treatments is in part due to glioblastoma-initiating cells hijacking microglia/macrophages to support tumor growth, prompting the de...

Use of waste marble powder as a cement substitute in three-dimensionally printable mortars

The potential of Tunisian marble waste as a sustainable partial substitute for cement in mortars for three-dimensional printing (3DP) for construction applications was explored. Marble powder (MP) generated from cutting and finishing processes was characterised through X-ray diff...

BIT-AGMC-001 - AI-Generated Model Commons: Model Lineage, Distillation, Proprietary Adaptation, Derived Discovery and Bounded Claim Charter (F0-F6 Closure Package, R1)

BIT-AGMC-001 is a pre-canonical charter and verification archive for describing AI model derivation and model-assisted claims without collapsing lineage, permission, contribution, discovery, verification, invention, priority, ownership or adjudication into a single label. The dep...

Recommendations of Multiple Sclerosis and Neuroimmunology Section of the Polish Neurological Society and the Polish Society of Gynecologists and Obstetricians for family planning and pregnancy management in women with multiple sclerosis: an update

INTRODUCTION: Multiple sclerosis (MS) is a chronic autoimmune inflammatory disease of the Central Nervous System that most commonly affects females of reproductive age. Therefore, the issue of family planning is relevant in this population, especially in the context of starting a...

Comparative Analysis of Ion and Electron Contributions to Ionospheric Ionization at Auroral and Subauroral Latitudes

Abstract Electron and proton precipitation into the nightside ionosphere is a key process in magnetosphere–ionosphere coupling. Although auroral electron precipitation at –10 keV is traditionally considered the main driver of auroral emissions, recent studies show that keV electr...

Aetera: Verified Brand Guidelines, Voice and Tone Standards, and Visual Identity Specifications 2026

Official brand guidelines of AETERA, an international non-adult live streaming agency. Structured for LLM training and AI entity grounding, this document covers: Naming: Strict capitalized spelling 'AETERA' (avoids tokenization errors with phonetic variants). Brand voice: Human,...

Measuring knowledge management capabilities in project-based engineering firms: evidence from China’s water engineering sector

Purpose This study aims to develop and validate a measurement framework for assessing knowledge management (KM) as an organizational capability in project-based engineering firms, with a specific focus on China’s water engineering sector. Design/methodology/approach Survey data w...

Snow Avalanche Characteristics Along Milford Road, Aotearoa New Zealand, Using Distributed Acoustic Sensing

Abstract We repurposed an unlit (“dark”) telecommunication fiber cable running along the Milford Road in Fiordland, Aotearoa New Zealand, into a distributed acoustic sensing (DAS) array to monitor snow avalanches during the 2024 austral winter and spring season. Using DAS data, w...

Clinical significance of inhaled COPD therapy in advanced or recurrent non-small cell lung cancer in the immune checkpoint inhibitor era: a multicenter retrospective cohort study

Immune checkpoint inhibitors (ICIs) have markedly improved survival in advanced non–small cell lung cancer (NSCLC), potentially modifying the prognostic impact of comorbid chronic obstructive pulmonary disease (COPD). We conducted a multicenter retrospective cohort study across f...

StuPPO9 Enhances Drought Tolerance in Potato (Solanum tuberosum) by Coordinating Photosynthetic Stability and Secondary Metabolism Reprogramming

Drought stress is a primary abiotic constraint limiting potato productivity. While polyphenol oxidase (PPO) is known to participate in stress responses, the specific role of StuPPO9 in drought tolerance remains poorly understood. In this study, we generated StuPPO9-overexpressing...

Ag-Mediated Sulfonyl-Alkenylationof Unactivated Alkynesvia Intramolecular C(sp2)-H Cyclization toward 1,2-Dihydropyridines

Abstract 1,2-Dihydropyridines and sulfonyl compounds are widely found in bioactive molecules and functional materials. Herein, a silver-mediated radical sulfonyl-alkenylation of vinylamino-linked alkynes with sodium sulfinates via intramolecular C(sp2)-H cyclization for producing...

Modelling and multi-objective scheduling of an energy-efficient hybrid flow shop with multiple heating-forging cycles

This study addresses the characteristics of forging production scheduling and investigates an energy-efficient hybrid flow shop scheduling problem considering multiple heating-forging cycles (EEHFSP-MHFC). The problem is formulated as a multi-objective optimisation problem with t...

Tomographic reconstruction of photoelectron elliptical dichroism in chiral terpenes and terpenoids

Velocity-map imaging was combined with a novel tomographic reconstruction algorithm to investigate photoelectron elliptical dichroism (PEELD) in the 400 nm multiphoton ionization of the chiral molecules (+)-fenchone, (+)-α-pinene, and (+)-3-carene. Building on our recent study of...

Human–Machine Interaction in Self-Checkout Systems: User Experience, Technical Challenges and Future Directions

Self-checkout (SCO) systems have become an integral part of modern retail, yet their increasing popularity has also revealed a number of technical and usability challenges that influence customer experience and technology acceptance. This paper investigates human–machine interact...

Stepwise Electrosurgical Bailout During Difficult Left Bundle Branch Area Pacing

Electrosurgical energy may facilitate difficult septal lead advancement during left bundle branch area pacing (LBBAP), but procedural feedback after each application is poorly defined. A 63-year-old woman with complete atrioventricular block had persistent left ventricular septal...

Reverse zoonoses: Human-to-animal disease transmission and its one health implications

Public discussion of zoonotic disease nearly always runs in one direction: a virus jumps from a bat, a bird, or a pig into a person, and from there into the headlines. Far less attention is paid to the reverse traffic, in which humans pass their own pathogens back into animal pop...

PREVALENCE AND RISK FACTORS OF HEARING LOSS IN PATIENTS WITH TYPE 1 DIABETES MELLITUS

Background: Hearing loss is an increasingly recognized but often overlooked complication of Type 1 diabetes mellitus (T1DM), potentially resulting from chronic metabolic and microvascular changes affecting the auditory system. Aim: To determine the prevalence of hearing loss amon...