Research works

LAB #4064 PROMISING: LEDGER BENCH: Apply filter: Min confirmations >= 6 — improves win rate from 32.5% to 38.2% (+5.7pp, — E8 Intelligence Research

IDEA: Adjustment made to the live model — verify against the backtests: Apply filter: Min confirmations >= 6 — improves win rate from 32.5% to 38.2% (+5.7pp, n=822) SAME-WINDOW EFFECT: Applying a minimum 6-confirmation filter would have eliminated the two `wkjudas` entries (GBPUS...

Containment of the Symbolic Cube in the Square for the Roulleau–Urzúa Configurations of Cubics

In an Oberwolfach report of 2015 Harbourne considered the configurations C_n of 4(n² − 3)/3 plane cubics due to Roulleau and Urzúa, defined when 3 divides n, and asked whether I^(3) ⊄ I² for the ideal I of the singular points of C_n. He reported that for C_3 the containment I^(3)...

Single-Molecule Studies Reveal That Water Starts to Protect Proteins Even at the ppm Level

Abstract A consensus established by extensive thermodynamic and structural studies of proteins and DNA is that water acts as an indispensable structural cofactor rather than a passive solvent for biomolecules. Nevertheless, it remains unclear whether trace water still exerts a st...

Effect of La on the Structure, Selectivity and Stability of La/Co3O4 Catalysts in Preferential Oxidation of Carbon Monoxide in Hydrogen-Rich Streams

Abstract The Co 3 O 4 -based catalyst was prepared via precipitation method, followed by lanthanum incorporation through incipient wetness impregnation. All catalysts were evaluated in the preferential oxidation (PROX) of carbon monoxide in hydrogen-rich streams. Catalysts were c...

Developing a drug-level feedback adherence counseling intervention for young MSM in the U.S.

Background: Young men who have sex with men (MSM) in the U.S. have suboptimal adherence to oral tenofovir-based pre-exposure prophylaxis (PrEP), undermining HIV prevention goals. Drug-level feedback using urine point-of-care tenofovir assays has improved adherence in Eastern and...

A framework for cost‐effective scalable revegetation planning: Experimental evidence of early establishment using native grass species

Abstract To ensure the effective allocation of funding, revegetation projects require transparent and integrated evaluations of costs and benefits. Yet, these elements are commonly omitted or reported separately, leaving stakeholders with an incomplete picture of the resourcing r...

Redox imbalance in urology: mechanistic insights into the development and progression of selected urological conditions

Abstract Reactive oxygen species (ROS) are key mediators of cellular signalling and play a vital role in regulating both physiological and pathological processes. In urologically relevant tissues, particularly the prostate, bladder and kidneys, redox processes influence vascular...

The Current State of Anterior Cruciate Ligament Reconstruction: Graft Selection, Lateral Augmentation, Rehabilitation, and Return-to-Play

Abstract Purpose of Review Anterior cruciate ligament reconstruction (ACLR) reliably restores anteroposterior stability; however, the rate of return to prior level of play and incidence of recurrent ACL injury have improved little over the past two decades. The purpose of this re...

How do different topical fluoride applications affect salivary and plaque fluoride levels for young children with dental caries?

Abstract A Commentary on Asavalertpalakorn C, Jirarattanasopha V, Nakornchai S, Horsophonphong S . Plaque and salivary fluoride levels in preschoolers following applications of silver diamine fluoride, sodium fluoride varnish, and their combination: a randomized clinical trial. I...

Vitamin D status and inflammatory Interleukins in women with and without polyendocrine metabolic ovarian syndrome: a cross-sectional exploratory study

Background Polyendocrine Metabolic Ovarian Syndrome (PMOS), formerly referred to as polycystic ovary syndrome (PCOS), is an intricate endocrine disorder, defined by a constellation of hormonal, metabolic, and reproductive irregularities. Vitamin D deficiency and increased levels...

LLM-Orchestrated Evasion of Tabular NIDS and GAN Augmentation for Multimodal Detection

Network Intrusion Detection Systems (NIDSs) based on machine learning have demonstrated strong performance against known attack patterns. However, their robustness against adaptive evasion strategies orchestrated by modern Large Language Models (LLMs) remains largely unexplored....

Treatment restrictions after acute stroke across nine European countries and their association with 90-day mortality: a post hoc analysis of the PRECIOUS randomised controlled trial

Background In patients with acute stroke, early withholding or withdrawal of life-sustaining therapies is associated with an increased risk of death. We used practice variation across nine European countries to assess whether this relation may be causal. Methods We performed a po...

Recurrence Rates and Outcomes After First Detected Atrial Fibrillation Episode in a Contemporary Hypertrophic Cardiomyopathy Center

Background: Atrial fibrillation (AF) is the most common sustained arrhythmia in hypertrophic cardiomyopathy (HCM), occurring in 20–25% of patients and associated with increased morbidity, stroke risk, and symptom burden. Despite this substantial clinical impact, the understanding...

Comparative genomics of seed dormancy using Brachypodium distachyon as a model for temperate cereals

Abstract Seed dormancy is a natural mechanism that delays germination until conditions are most suitable. Previous studies have shown that phylogenies and environmental conditions shape the evolutionary trajectories of seed dormancy, making it an interesting subject for comparati...

An Explainable Transfer Learning Framework Based on Acoustic Spectral Portraits for Pipeline Leak Diagnosis Across Composite Operating and Acquisition Conditions

This study proposes an explainable and lightweight pipeline leak-diagnosis framework based on a leak-oriented Acoustic Spectral Portrait (ASP) processing pipeline and transfer learning. The ASP processing pipeline converts one-dimensional acoustic emission signals into compact tw...

Averaged Depth and Duration of Snow Cover in the Mountain Regions of Bulgaria

In two consecutive papers, we tried to fill a knowledge gap in the snow research in the Bulgarian mountains and to estimate the current snow conditions in these regions. In the previous study, we encountered a significant increase in mean winter air temperatures at all elevations...

Temporal Dynamics of Emerging Cardiovascular Biomarkers in the Early Phase After Acute ST-Segment Elevation Myocardial Infarction: A Prospective Single-Center Pilot Study

Introduction: Acute ST-segment elevation myocardial infarction (STEMI) remains a major cause of cardiovascular morbidity and mortality. Despite successful primary percutaneous coronary intervention (pPCI), early myocardial injury and stress may contribute to left ventricular dysf...

Deep-Economic Dispatch: A Deep Reinforcement Learning Framework for Optimal Power Generation Scheduling in Real-Time Electricity Markets

The increasing complexity of real-time electricity markets and fluctuating load demands challenges traditional economic dispatch methods, which often fail to balance cost efficiency and system reliability. This study presents a Deep Reinforcement Learning (DRL) framework for real...

Burden of cardiovascular disease in Brazil, 1996–2023: a retrospective descriptive study of the epidemiology and impact on public healthcare

Background Cardiovascular diseases (CVD) are the leading cause of death worldwide, and their epidemiology is correlated with genetic predisposition and exposure to risk. Brazil is a developing country with a vast territory, which leads to structural inequalities. We aimed to comp...

Liquid-Crystalline Polymer Alloy Design through Interfacial Reactions Enabled by In Situ Polymerization and Reactive Blending

Abstract Liquid-crystalline polymers (LCPs), an important class of super engineering thermoplastics, exhibit outstanding melt processability and are attractive materials for designing high-performance polymer alloys. However, the fundamental insights required to overcome macrosco...