Research works

Accelerating biomass loss from forest disturbances across Europe

Abstract Forest disturbances are rising globally due to climate change and land-use pressures, weakening the terrestrial carbon sink. However, declines in aboveground biomass from tree cover loss remain poorly quantified, limiting our understanding of the role of disturbances in...

A dependency map enhanced with next-generation 3D cancer models

Despite advances in precision oncology, effective personalized treatments are still lacking for most patients with cancer1. The Cancer Dependency Map (DepMap) accelerates this field by systematically identifying cancer vulnerabilities in diverse preclinical models. Data from over...

Making sense of the extraordinary – An investigation of the content and prevalence of appraisals of nonordinary experiences

Individuals around the world report nonordinary experiences that stand out to them compared to their day-to-day or ordinary experiences. Yet, they can be appraised in very different ways, resulting in wellbeing and personal growth, or in marginalization and mental health problems...

A tumour-derived organoid biobank maps cancer gene dependencies

Abstract Cancer cell lines remain foundational for research and drug discovery, yet they incompletely capture tumour diversity, lack linked patient context, and have undergone adaptation to culture. Tumour organoids are three-dimensional cultures derived from patient tissue that...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...

Review of Particle Physics *

The Review summarizes much of particle physics and cosmology. Using data from previous editions, plus 3,200 new measurements from 903 papers, we list, evaluate, and average measured properties of gauge bosons and the recently discovered Higgs boson, leptons, quarks, mesons, and b...

Ontosystematics: Foundations of a Systematic Science of Ontological Nodes

Ontosystematics is the positive conceptual science of ontological nodes: their identity, composition, difference, inheritance, migration, transformation, and recombination across the habitats that host them. Its founding distinction separates a habitat — any historically occurrin...

Spatial surface gravity of small bodies from polyhedral shape models: slope, geopotential, and the resolution robustness of geopotential dispersion

Three companion papers established that the area-weighted mean surface gravity ⟨g⟩ of a small body can be estimated from a polyhedral shape model, without an independently determined density (Papers I–III). A single scalar, however, cannot say where on a body the gravity is high...

The Observer's Distortion Coefficient (Part II): Digital Topology and Computational Latency as a Replacement for Dark Matter: A 98% Predictive Fit for NGC 2403 and an Unfiltered 90.83% Universal Global Audit

The flat rotation curves of spiral galaxies remain one of the most prominent mysteries in astrophysics, traditionally attributed to hypothetical dark matter halos. In this paper, we expand our topological framework to a rigorous global ensemble analysis using the entire SPARC (Sp...

Geometric and Spectral Desingularization

There are two seemingly independent paradigms for resolving singularities: the geometric route — Arnold's σ-process, or blow-up, which replaces the singular point by the space of directions through it — and the spectral route — the Möbius transform, which turns sign-flipping (two...

Flexural–Torsional Buckling Behavior of FGP Curved Beams Based on a Modified Variational Method

Abstract This study presents a modified variational modeling method for the flexural–torsional buckling of functionally graded porous (FGP) curved beams. Unlike conventional methods that rely on strictly admissible functions, the proposed framework accommodates arbitrary orthogon...

Synergistic Constructionof Composite Conductive Networksand Particle Size Gradation toward High-Volumetric-Energy-DensityLiMn x Fe1– x PO4 Cathodes

Abstract The commercial deployment of LiMnxFe1–xPO4(LMFP) cathodes is hindered by the Mn3+ Jahn–Teller effect, low electronic conductivity, and low compacted density resulting from intensive gas evolution during conventional pyrolysis. Herein, a comprehensive modification strateg...

Hamana’s injective envelope as a maximal rigid multiplier cover

Abstract Let A be a unital $$C^*$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mi>C</mml:mi> <mml:mo>∗</mml:mo> </mml:msup> </mml:math> -algebra. An A -multiplier cover is a $$C^*$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup>...

Surface roughness dating for lava flows: a new remote sensing geochronometer for volcanic hazard assessment

Abstract Regional geologic histories are key to mitigating the impact of geologic hazards on nearby communities, but standard geochronology remains costly and labor-intensive. In contrast, surface roughness derived from high-resolution topographic data is an emerging technique fo...

Minimal Non-Units, Prime-Support Boundaries, and Batch Unit Testing: A Structural Reformulation and Open Decision Problem for Deterministic Integer Factorization

This audit-corrected preprint consolidates research notes V0.2–V1.0 on deterministic integer factorization. It identifies the least prime factor of a composite integer as the first non-unit in natural order modulo N, separates prime-support information from evaluation circuit and...

EngineeringIntermediate Phases in Topotactic PhaseTransitions of Cobaltite Perovskites

Abstract Topotactic phase transitions in perovskite cobaltites (R1–xAxCoO3−δ; R = rare earth, A = alkaline-earth ion) play a key role in the operation of neuromorphic devices, where oxygen vacancy concentration (δ) modulates resistive switching. However, the emergence of an insul...

Nanoscale Insights:Exploring Undersaturated Crystallizationof Flufenamic Acid with Liquid Phase Transmission Electron Microscopy

Abstract Pharmaceutical crystallization traditionally requires supersaturation to occur and is typically monitored through macroscopic characterization methods that can measure induction times and growth rates. However, detailed insights revealing the precise steps and mechanisms...

Rapidly enlarging port-site mass after thoracoscopic lung resection: desmoid-type fibromatosis mimicking pleural recurrence

Abstract Background Desmoid-type fibromatosis is a rare, benign fibroblastic neoplasm characterized by infiltrative growth and a tendency for local recurrence despite the absence of metastatic potential. It has been associated with prior trauma or surgery, and postoperative lesio...

Disparities in Hospital Length of Stay and Morbidity in Acute Care Pediatric Cardiology Patients

BACKGROUND Multicenter collaborative studies examining disparities in in-hospital outcomes are lacking in pediatric cardiology. We hypothesized that Black and Hispanic patients in pediatric acute care cardiology units (ACCUs) have increased length of stay (LOS) and complications...

Factors influencing female physicians’ careers in the German-speaking part of Switzerland

Despite an increase in female physicians in Swiss hospitals, most executive positions are still held by male physicians. This study aimed to identify obstacles and institutional factors influencing female physicians' careers and to evaluate ways to support their professional adva...