Research works

The Karatas Quantum–Consciousness Field Framework (KQCF): Integrating Biological Encoding, Epigenetic Dynamics, and Universal Information Flow

This paper introduces the Karatas Quantum–Consciousness Field Framework (KQCF), a multi-layer theoretical model integrating molecular biology, epigenetics, neural dynamics, and quantum information theory. The framework proposes that consciousness emerges through dynamic coupling...

Modelling the effects of travel time use on mode choice and the value of travel time savings: tackling self-selection and endogeneity bias

Preferences for travel-based activities may lead individuals to choose travel modes that best accommodate activity needs. In theory, “passengerised” modes, such as public transport and automated vehicles (AVs), could become the preferred travel options, as they enable a wider ran...

A multi-ancestry polygenic risk score for body mass index predicts longitudinal weight change

Abstract Background Identifying individuals at risk for future weight gain is challenging, partly because associations with traditional clinical risk factors may be biased by confounding and reverse causation. Polygenic risk scores (PRS) provide a stable, lifelong measure of gene...

Recent lifestyle change impacts sleep and circadian rhythms among the Indigenous peoples of Peninsular Malaysia

ABSTRACT Sleep disorders are rising globally, but their lifestyle causes remain unclear. We recorded sleep-wake patterns via actigraphy from 1036 Orang Asli adults across 12 communities in Peninsular Malaysia undergoing market integration, marked by changes in permanent infrastru...

Single fuel particle emissivity evolution of biomass, coal and coal char

In solid fuel combustion systems, reacting particles form the hottest surfaces and, therefore, contribute significantly to the radiative heat balance within these environments. Recently, experimental investigations of single-particle emissivity report values for coal and various...

Social cues on stone tools outweigh raw material properties in wild primates

1. Abstract The ability to select appropriate tool material enabled early hominins access to new resources and environments. The underlying mechanisms driving tool selection effectively remain unknown. Observations of extant primates have demonstrated strong selectivity for speci...

Ethical Ontology, Volume II — Episode Registries, Parts II–VI, V1.1

Part-level episode registries for Ethical Ontology, Volume II, executed under Out-of-Sample Trial Preregistration V1.1 (10.5281/zenodo.21744060), which registers the trial protocol and requires that the historical sample be fixed in advance of any verdict. The sample was publicly...

Preregistration of a Reflexive Node-Classification Trial in Ontosystematics: positive no-ground across two articulations

Conditions fixed in advance for the reflexive node-classification trial of the Ontosystematics founding article. The candidate is the determination that the common constitutes what acts without answering for it and that what remains when the ground-function is refused is a positi...

Preregistration of the Categorial-Gap Trial: the modal coincidence between Positive No-Ground and Ethical Ontology, Volume I

Conditions fixed in advance for a trial of the corpus's own novelty claim. Positive No-Ground determines the common as possibilising necessitation and the locus of answerability as singularising necessarisation; Ethical Ontology, Volume I determines the who as their modal coincid...

Measurement Drift During the MCP 2026 Transition: Two Revision-Aware Audit Waves of Publicly Discovered Endpoint URLs

Measuring protocol migration while the measurement instrument is itself changing creates a risk of mistaking instrument coverage for ecosystem change. This preprint reports two revision-aware audit waves derived from a frozen, append-only Model Context Protocol (MCP) observation...

Preregistration of a Reflexive Node-Classification Trial in Ontosystematics: positive no-ground across two articulations

Conditions fixed in advance for the reflexive node-classification trial of the Ontosystematics founding article. The candidate is the determination that the common constitutes what acts without answering for it and that what remains when the ground-function is refused is a positi...

Colorectal Cancer Mortality Following an Organized Fecal Immunochemical Test–Based Screening Program

Importance Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide. Organized screening programs using the fecal immunochemical test (FIT) have been implemented to reduce CRC mortality through early detection. Objectives To evaluate the association betwee...

Tirzepatide and the risk of atherosclerotic cardiovascular events: population based cohort study

Abstract Objective To estimate the magnitude of reduction in major adverse cardiovascular events (MACE) that would be observed in clinical practice from adding tirzepatide to standard of care treatment. Design Population based cohort study, using a design, data, and analytical ap...

Dissent enhances the credibility of groups of Bayesian conformist decision-makers

When making a decision, individuals use their private information to evaluate the available options. In a group, they can also learn from other group members' choices, which partially reveal their own private information. Bayesian estimation provides tools for modelling decisions...

Reimagining digital literacy and virtual identity in the Age of AI” - Special Collection Editorial

This special collection reflects on the need to reimagine teaching and learning spaces in the age of artificial intelligence (AI). Understanding digital literacy and virtual identity is essential to engaging with our contemporary society, which is defined by the fast pace of soci...

Decolonization vs Enhanced Cleaning for Multidrug-Resistant Organism Reduction in Nursing Homes

Importance Universal decolonization and enhanced cleaning are strategies to prevent multidrug-resistant organism (MDRO) transmission. Whether their associations with MDRO burden are overlapping, additive, or synergistic remains unknown. Objective To evaluate independent and combi...

The rise of carnivoran mammals in Europe through the lens of body mass

Carnivoran mammals (cats, dogs, bears, seals, etc.) and their kin radiated during the Palaeogene, among other carnivorous clades (hyaenodonts, mesonychians, and oxyaenodonts). This radiation has often been framed as a competition ultimately won by carnivorans, but the data suppor...

Extensive binding of poorly characterized human transcription factors to genomic dark matter

Abstract The functional impact of a large portion of the human genome known as “dark matter DNA”, which is composed mainly of repeat sequences, remains unknown. The genome also encodes many putative and poorly characterized transcription factors. Here, we determine genomic bindin...

An expanded codebook of human transcription factor DNA-binding specificity

Abstract Gene expression is regulated by transcription factors (TFs), which recognize specific DNA sequence motifs. Several hundred putative human TFs, identified mainly by an apparent DNA-binding domain, lack known binding motifs 1 . Furthermore, even for well-characterized TFs,...

Carrying Firearms and Suicide Risk Among Adolescents

Importance Firearms are the most lethal method of suicide across all ages, with case fatality rates exceeding 90%, warranting urgent public health concern. Understanding how carrying of firearms by adolescents and suicide risk vary by race and ethnicity and by stringency of state...