Research works

Medical information and decision-making in palliative cancer: a qualitative study of patients’ perceptions, needs, and preferences regarding physician communication

BACKGROUND: Patients with advanced cancer are frequently confronted with complex treatment decisions in the context of high emotional burden and potential limited prognostic benefit. Physician communication and the provision of medical information are therefore central to informe...

The impact of twine materials on the catch efficiency of abandoned, lost or otherwise discarded fishing gear (ALDFG) on crustaceans: an experimental study from Turkish inland set net fishery

Context Abandoned, lost or otherwise discarded fishing gear (ALDFG) represent a persistent pollution source in freshwater ecosystems, continuously capturing crustaceans long after being converted into ghost nets. Aim This study aims to experimentally determine the effects of the...

Emerging innovations in movement ecology to address planetary challenges

Abstract Movement ecology—the study of how and why animals move within their environments—stands to offer transformative insights into our rapidly changing world, with benefits for both nature and people. Here, we present the first global horizon scan for movement ecology, engagi...

Scaling up fabrication of thin-film nanocomposite (TFN) membranes: Methods, challenges, and applications

Abstract Thin-film nanocomposite (TFN) membranes have received significant attention because of their excellent separation performance, structural flexibility, and tunability. As the demand for high-efficiency membrane technologies in industry grows, it becomes imperative to tran...

Enhancing energy efficiency in crude distillation units via process simulation and SQP-based optimization

Abstract The paper introduces a unique approach combining Aspen HYSYS simulation, actual refinery operating data (Basrah refinery), ASTM D86-based validation, and sequential quadratic programming (SQP) optimization into one practical framework in the context of energy optimizatio...

Platelets as regulators of anti-tumor immunity: mechanisms and clinical implications

Platelets are increasingly recognized as important contributors to tumor progression and metastatic dissemination. Platelets facilitate cancer cell survival, their safe transit through the hostile bloodstream, arrest at distant organ sites, and ultimate outgrowth into metastatic...

Maximal Compound Curvature as a Complete Observable for Finite Partition Functions

Let $Z^g(\beta)=\sum_{j=1}^{m}g_j e^{-\beta e_j},$ $\qquad 0<g_j,\qquad e_1<\cdots<e_m,$ be a primitive finite weighted partition function. Its Hankel compound partition functions are $\tau_r^g(\beta)$ $=\det\!\bigl(M_{a+b}(\beta)\bigr)_{a,b=0}^{r-1},$ $\qquad$ $M_n(\beta)=\sum_j...

In-depth characterisation of the tumour microenvironment reveals HHV-8-dependent immune regulation in HIV-associated and classic Kaposi sarcoma

BACKGROUND: Kaposi's sarcoma (KS) is the most common malignancy occurring in people living with HIV (PLWH). The clinical course of KS in PLWH established on combined anti-retroviral therapy (cART) resembles that of classic KS. OBJECTIVES: To compare the clinical and biological ch...

Pit stop off the humpback highway: multi agency response to a sub-adult humpback whale Megaptera novaeangliae in Sydney Harbour, Australia

The east coast Australian humpback whale Megaptera novaeangliae population continues to recover post-whaling and is now estimated to be at least 50,000 individuals. The combination of population growth and increased human activities within coastal environments means there is a hi...

Cumulative non-high-density lipoprotein cholesterol exposure and residual cardiovascular mortality risk in patients with peripheral artery disease

Abstract Background Individuals with peripheral artery disease (PAD) face substantial residual cardiovascular risk despite lipid-lowering therapy. Non-high-density lipoprotein cholesterol (non-HDL-C) has been recognized as a more comprehensive marker of cardiovascular risk than l...

Targeting FibroblastActivation Protein for PrecisionMedicine

Conspectus The advancement of precision medicine depends critically on well-defined molecular targets. Pathologically activated fibroblasts drive disease progression in cancer, fibrosis and chronic inflammation through sustained inflammation, extracellular matrix remodeling and p...

Adult mental health service outcomes for patients of child and adolescent mental health services: a total Scottish birth cohort study

Abstract Child and adolescent mental health services (CAMHS) provide a critical opportunity for early mental health interventions. Evidence is still scare, however, on the long-term mental health outcomes of CAMHS patients, including their subsequent adult mental health service u...

Data-Driven Digital Twin for Amylosucrase from Deinococcus geothermalis : Accelerating Acceptor Discoveryin Transglycosylation Reactions

Abstract Enzymatic transglycosylation by Deinococcus geothermalis amylosucrase (DgAS) offers a cost-effective route for enhancing the physicochemical properties of bioactive flavonoids. However, predicting DgAS acceptor specificity remains challenging due to complex structure–act...

From Disclosure Controls to Statutory Enforcement: Regulating Corporate Greenwashing through Forensic Accounting and a Comparative Analysis of HK SFC and UK FCA Regimes

As corporate sustainability disclosures transition from voluntary reporting to statutory mandates, corporate greenwashing presents a structural threat to financial market integrity and sustainable capital allocation. Utilizing a desk-based qualitative framework combining doctrina...

Endoscopic versus catheter-based minimally invasive evacuation of spontaneous supratentorial intracerebral hemorrhage: a systematic review and meta-analysis

Abstract Minimally invasive surgery (MIS) for spontaneous supratentorial intracerebral hemorrhage (sICH) includes endoscopic evacuation and catheter-based evacuation (aspiration or drainage ± thrombolysis), but comparative performance remains uncertain. We performed a systematic...

Mental Health Disorders, Suicide Attempts, Substance Use, and Substance Use Disorders in Adults with Fetal Alcohol Spectrum Disorders: A Gender-Separated Study

Abstract Fetal alcohol spectrum disorders (FASD) are a group of neurodevelopmental disorders caused by alcohol exposure during pregnancy. FASD is associated with various neurocognitive disorders over the entire lifespan. Comorbid mental health disorders seem to be highly prevalen...

Single-session therapeutic plasma exchange as salvage therapy for pegaspargase-induced severe acute pancreatitis accompanied by multiple organ dysfunction in a pediatric patient with B-cell precursor acute lymphoblastic leukemia: a case report

Abstract Background Pegaspargase-related severe acute pancreatitis (SAP) combined with persistent multiple organ dysfunction syndrome (MODS) is a life-threatening adverse reaction in children receiving acute lymphoblastic leukemia (ALL) chemotherapy. Standard intensive supportive...

Cross-Sector Pattern from Two Constants: Eight Standard-Model Observables Constrained by p and q

We report an empirical pattern in which eight Standard Model observables—the Higgs mass, the top-quark mass, three PMNS mixing angles, two CP-violating phases, and the strong coupling constant—are constrained to within ±1% by two constants, p≈0.5437 and q=1/5, with zero adjustabl...

p38β-mediated BiP phosphorylation drives stemness and chemoresistance by suppressing UPR activation in hepatocellular carcinoma

Abstract Tumor-initiating cells (TICs) promote tumor initiation and therapy resistance, yet the kinase regulators that sustain TICs remain incompletely defined. Here, we identify the stress kinase p38β (MAPK11) supports TIC maintenance and drug resistance in hepatocellular carcin...

Integrative multiomic analysis identifies transcription factors and target proteins in renal cell carcinoma

Abstract Renal cell carcinoma risk is partly shaped by germline genetic variants that often reside in regulatory regions. However, the transcription factors (TFs) and downstream proteins via which they shape RCC susceptibility remain incompletely characterized. Here we show that...