Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
79858 work(s)
- AI & ComputingOpen access
Single-Chain Persistence Theory II: The Mathematical Foundations of Persistence
This paper is the mathematical middle layer between Single-ChainPersistence Theory I (SCPT-I) and Single-Chain Persistence Theory III (SCPT-III) . SCPT-I bears the burden ofproof; the present paper formalizes the four criteria and answers the question “why the fourcriteria can be...
- Health & MedicineOpen access
Clear cell Paget disease with underlying malignancy: A case report and review of literature
Paget's disease of the breast (PDB) is a rare form of breast cancer, characterized by the existence of Paget cells. It accounts for nearly 1%-3% of all breast cancers. Glycogen-rich clear cell ductal carcinoma in situ (DCIS) of the breast is an infrequent occurrence. The current...
- Society & Economics
노인의 사회적 고립은 노인의 건강 악화 및 사회적 비용을 증가시키는 사회 문제로서 대두되고 있다. 코로나19가 유행하며 디지털 전환의 가속화는 노인의 디지털 격차와 사회적 고립 문제를 심화시켰다. 이에 본 연구는 노인의 디지털 사용과 사회적 고립에 대한 키워드 및 담론의 구조와 변화 양상을...
- Climate & EnvironmentOpen access
Orange peel powder (OPP) has been widely explored for dye adsorption; however, its limited adsorption capacity and poor separation efficiency restrict its practical applicability. In this study, magnetic Fe 3 O 4 nanoparticles were successfully integrated with OPP through a green...
- Climate & EnvironmentOpen access
Vegetarian or vegan diets have been associated with favorable cardiovascular outcomes in the general population; however, their effects on cardiometabolic risk factors in patients with established cardiovascular disease (CVD) remain unclear. This systematic review and meta-analys...
- Health & MedicineOpen access
EGFR (epidermal growth factor receptor)-targeted therapies, which utilize small molecule inhibitors such as erlotinib and osimertinib to inhibit aberrantly activated EGF receptors caused by oncogenic mutations such as L858R and exon 19 deletion occurring primarily in the region c...
- Health & MedicineOpen access
Early detection of sepsis is essential for reducing mortality, but diagnosis can be delayed because symptoms of sepsis are often non-specific, frequently mimic other conditions and differ between individuals. We implemented COMPOSER-LLM, an enhanced sepsis prediction system that...
- Society & EconomicsOpen access
Background Child sexual abuse (CSA) is a major public health concern, yet rigorously evaluated and fully manualized primary prevention programs for preschool children remain scarce. Evidence on the feasibility and acceptability of such interventions among young children and their...
- BiologyOpen access
Oat ( Avena sativa L.), a key forage crop, is highly susceptible to water deficit. Many studies have elucidated the mechanisms through which oat leaves respond to drought; however, little is known about these mechanisms in roots. We compared the physiological, transcriptomic, and...
- Health & MedicineOpen access
Multiple Sclerosis (MS) is an inflammatory neurodegenerative disease with incompletely understood aetiology beyond the HLA-DRB1 locus. Mitochondrial haplogroup U, prevalent in Middle Eastern and Near Eastern populations, encodes functional variants in NADH dehydrogenase subunits...
- Society & Economics
노인일자리가 확대되고 있는 상황에서 참여자 특성과 다양한 작업환경 등으로 인한 안전사고 위험이 내재되어 있다. 이에 본 연구는 2025년 노인일자리 및 사회활동 지원사업 실태조사 자료를 활용하여 노인일자리 참여자의 안전실천행동이 안전보호에 미치는 영향에서 안전교육 효과성 인식의 조절효...
- Society & Economics
디지털 전환이 가속화된 사회적 맥락에서, 본 연구는 국내 언론이 노년층의 디지털 리터러시를 어떠한 의미 구조와 주체성의 틀로 재현하는지를 탐색하였다. 연구의 이론적 기반으로 WHO가 제시한 능동적 노화 2.0의 핵심 가치인 기능적 능력, 사회적 포용, 디지털 시민성을 설정하고, 2020년 이후 보...
- Society & EconomicsOpen access
While sustainability has emerged as a critical mega-trend reshaping business strategies worldwide, little is known about how adaptive marketing capabilities foster corporate environmental sustainability and whether these capabilities translate into improved firm performance. This...
- BiologyOpen access
Exosomes in brain diseases: Mechanisms, advances, and perspectives
The blood–brain barrier (BBB) remains a major biological obstacle limiting the effective delivery of therapeutics for central nervous system (CNS) disorders. Although conventional drug delivery approaches have achieved continuous advances, their clinical translation is frequently...
- Society & EconomicsOpen access
Global trade-offs between consumption, carbon prices and equity
As the remaining carbon budget continues to dwindle, economic growth strains efforts to limit global warming to 1.5 °C. Reducing unnecessary production and consumption in high-income regions and among the wealthy, and organising production more around human needs and human well-b...
- Health & Medicine
Celebrating the nation’s 250th: America’s first hospital pharmacy
Compounding drugs, seeking operational funding, and administering medications to patients. The nation’s earliest hospital pharmacists shared some duties with today’s pharmacists—though they were also, literally, pulling teeth. To mark the nation’s 250th anniversary, the ASHP News...
- BiologyOpen access
Ligase enzymes for the synthesis of peptide therapeutics
Peptides are widely used as therapeutics and in many other important applications. However, current chemical synthesis of peptides is highly step- and atom-inefficient, requiring deleterious reagents and solvents, which creates harmful waste. Alternative methods for more sustaina...
- BiologyOpen access
AI-guided De Novo design of DHPS inhibitors
Hypusine modification of eIF5A by Deoxyhypusine Synthase (DHPS) is essential for the replication of a broad range of viruses, making DHPS an attractive host-directed therapy (HDT) target for antiviral drug discovery. AI-based drug design methods spanning binding affinity predicti...
- Health & MedicineOpen access
Mucinous adenocarcinoma of the colon is defined by extracellular mucin occupying at least 50% of the tumour. Although it is often regarded as a distinct histological subtype, its clinicopathological profile remains variable across published series. We compared mucinous and classi...
- Materials & EnergyOpen access
Prediction of plutonium content of BWR/MOX fuel using a neural network
The Nuclear Material Balance (NMB) code is a comprehensive nuclear fuel cycle simulator developed by the Institute of Science Tokyo and the Japan Atomic Energy Agency. By modeling a fleet of reactors, fuel cycle simulators like NMB can help to optimize uranium and plutonium utili...