Research works

Promises and pitfalls of mRNA-based vaccines as cancer treatment

The success of mRNA-based COVID-19 vaccines has accelerated interest in applying mRNA technology to oncology. mRNA cancer vaccines offer the potential for precise, patient-specific treatment with reduced off-target effects and may become an important component of future cancer ca...

Factors Associated with Use Intention for Care Farming–Based Adult Day Care Services Among Pre-Older Adults

본 연구는 향후 노년기에 진입할 예비 노년층을 대상으로 치유농업 기반 노인주간보호서비스에 대한 이용의향을 파악하고, 이용의향과 관련된 요인을 확인하는 데 목적이 있다. 이를 위해 만 40세 이상 64세 이하를 대상으로 온라인 설문조사를 실시하였으며, 최종 분석에는 397명이 포함되었다. 수집...

Effects of dietary supplementation with Enterococcus faecalis JM263 on growth performance, antioxidant status, rumen microbiota and metabolism in yaks

Yaks are vital to the ecology and economy of the Qinghai-Xizang Plateau. The unique environmental conditions of this high-altitude region have shaped yaks, leading to significant differences in their evolution from other cattle species. From yak gut contents, we isolated Enteroco...

Prognostic factors of synchronous endometrial and ovarian cancers: a systematic review and meta-analysis of cohort studies

Accurate identification of prognostic factors at the time of diagnosis in patients with synchronous endometrial and ovarian cancers (SEOC) is critical for guiding aggressive treatment strategies and intensive post-treatment surveillance. However, existing studies have reported in...

Analysis of the Effects of Wall Thermal Properties and Insulation Location on CTSF and Heat Gain

In Korea, the RTS-SAREK program, developed by the Society of Air-Conditioning and Refrigerating Engineers of Korea (SAREK), is widely used to estimate the peak cooling load of non-residential buildings. This program is based on the ASHRAE Radiant Time Series (RTS) method and inco...

Human iPSC-based skeletal muscle model of LAMA2-related congenital muscular dystrophy

Congenital muscular dystrophies (CMDs) are rare, devastating pediatric conditions with no specific treatment or cure. The most common form, LAMA2-related CMD, or LAMA2-CMD (previously known as merosin-deficiency and MDC type 1 A), is caused by myofiber instability from loss of th...

Pregnancy loss and prevalent cardiometabolic multimorbidity: a two-stage individual participant data analysis of CHARLS, ELSA, and HRS

Cardiovascular disease remains the leading cause of death worldwide, and cardiometabolic multimorbidity (CMM) is associated with substantially higher mortality and reduced life expectancy. Pregnancy loss is common and has been linked to later cardiovascular risk, but multinationa...

Calculation of Solar Heat Gain Orientation Factors in Accordance with Korea’s Building Energy-Saving Design Standards

This study introduces solar heat gain orientation factors for the four climate regions specified in the Building Energy-Saving Design Standards. An orientation factor is defined as the ratio of solar irradiance incident on a vertical plane of a given orientation to the global hor...

Successful caesarean section under spinal anaesthesia in a pregnant woman with guillain–barré syndrome: a case report from a resource-limited setting

Guillain-Barre syndrome (GBS) is a rare but serious neurological condition due to autonomic instability, decreased respiratory function, and unpredictable medication responses, which can make pregnancy difficult and provide considerable anaesthetic issues. We report a case of a 2...

Efficacy and safety of scaling and root planing for non-alcoholic fatty liver disease

To evaluate the effects of scaling and root planing (SRP) on stage of hepatic steatosis measured by abdominal ultrasound (US) in patients affected by Metabolic Associated Fatty Liver Disease (MAFLD) and periodontitis. In this preliminary retrospective observational study, 205 adu...

Associated prognostic impact of opioid use before Transcatheter aortic valve implantation – A Danish nationwide cohort study

Background Opioid use is frequently reported as a baseline characteristic in transcatheter aortic valve implantation (TAVI) cohorts, yet its prognostic implications have not been examined. Aim To examine the association between pre-procedural opioid use and post-TAVI outcomes. Me...

A study on iNOS, eNOS, and CD71 expression in preeclampsia: findings shedding light on possible gaps in the current understanding of pathogenesis

Preeclampsia is a multisystem disorder associated with significant maternal and fetal morbidity, yet its underlying mechanisms remain incompletely understood. Oxidative stress is believed to play a central role in its pathophysiology. This study aimed to investigate the relations...

The impact of FTO and ADRB3 gene variants, physical activity and proper diet on weight gain and perinatal outcomes in pregnant women with obesity

This study aimed to evaluate the effects of FTO (rs9939609) and ADRB3 (rs4994) gene variants, dietary intervention, and physical activity on gestational weight gain and perinatal outcomes in women with obesity and early gestational diabetes (GDM). In this prospective study, 115 p...

Acoustic higher-order topological metals with bound corner states in the continuum

Two-dimensional topological insulators for first order and higher order, characterized respectively by in-gap edge states and corner states, have attracted tremendous research interest. Different from them, two-dimensional topological metals exhibit topological boundary states in...

Development of a 1D Model and Performance Analysis at Extremely Low Temperature of an R290 Indirect Heat pump System with Vapor-Injection

Propane (R290) is a promising alternative refrigerant for electric vehicle (EV) heat pumps, particularly with tightening regulations on PFAS. This study developed a 1-D GT-SUITE model of an R290-based indirect heat pump system (IDS-HP) to investigate the effect of vapor-injection...

The Relationship Between Educational Level and Cognitive Function in Older Adults: Focusing on the Pathways of Social Participation and Depression

교육수준과 인지기능 간의 관련성은 반복적으로 보고되어 왔으나, 사회참여와 우울이라는 서로 다른 심리사회적 경로를 하나의 모형에서 동시에 검증한 연구는 제한적이다. 본 연구는 노인의 교육수준과 인지기능 간의 관계에서 사회참여와 우울의 병렬 매개모형을 적용하여 사회참여와 우울의 간접경...

Applying the mastery-engagement matrix in asynchronous first-year library instruction

This study investigates the relationship between asynchronous library video tutorial engagement and information literacy mastery among 707 first-year university students. Adopting a quantitative methodological approach, this study utilizes Springshare's LibWizard for formative as...

The Therapeutic Potential of Ketamine as a Treatment for Amyotrophic Lateral Sclerosis: A Narrative Review Focusing on Sigma-1 Receptor Modulation, Mitochondrial Function, and Neuroplasticity

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease characterized by progressive motor neuron degeneration. Current Food and Drug Administration (FDA)-approved treatments provide only modest benefits and do not substantially alter disease trajectory, un...

Development and validation of the “Yucan-1” 5 K liquid chip for genomic studies in the silkworm (Bombyx mori)

The silkworm ( Bombyx mori ) is a lepidopteran model of paramount economic and scientific importance. While genomic resources are available, a high-throughput, cost-effective, and breed-specific genotyping platform for targeted genetic studies in Chinese local breeds, particularl...

Clinical-guided deep learning framework for diabetic retinopathy: integrating lesion-aware attention, adversarial augmentation, and uncertainty quantification

The global prevalence of diabetic retinopathy (DR) is increasing in parallel with the rising burden of diabetes, posing a substantial public health challenge. Current automated DR screening systems often lack lesion-level interpretable, robustness against class imbalance, and rel...