Research works

Strict Total Positivity of Order Four for the de Bruijn--Newman Kernel

We prove that the de Bruijn--Newman kernel associated with the Riemann Xi function is strictly totally positive of order four. Let \[K(x,y)=\Phi(x-y),\] where \(\Phi\) is the classical positive even Riemann kernel. We establish that for every \[1\le m\le4,\] and every pair of str...

Spatiotemporal variability and trends of precipitation, temperature, and evapotranspiration in the Muger sub-basin of the Abbay basin Ethiopia

Abstract This study used time series data from 1980 to 2022 to investigate spatiotemporal changes and trends of precipitation, temperature, and evapotranspiration in Muger sub-basin. The coefficient of variation (CV), precipitation concentration index (PCI), and seasonality index...

Glimpse into the past: Analyses of the middle and inner ear of extinct rodents (Eusciurida; Rodentia; Mammalia) with implications for their locomotory behaviour

Abstract Rodentia is the most diverse and species-rich group of mammals, inhabiting almost all regions and ecosystems on earth. One of the most specialised subgroups is the Eusciurida, composed of Sciuridae, Gliridae, and Aplodontia rufa , and characterised by arboreal, fossorial...

Recurrent Deliberate Foreign Body Ingestion: Psychiatric Comorbidities, Management Strategies, and Ethical Considerations

PURPOSE OF REVIEW: Recurrent deliberate foreign body ingestion (DFBI) is a high-risk, resource-intensive behavior most often associated with underlying psychiatric conditions. Although medical and surgical complications are well documented, the psychiatric drivers and optimal man...

MultidimensionalQuantitative Analysis of BiologicalResponses to DNA Nanoassemblies with Defined Structure and SurfaceChemistry

Abstract DNA nanoassemblies (DNs) have emerged as programmable platforms for biomedical applications; however, a quantitative understanding of how structure and surface chemistry jointly govern their biological behavior remains limited. Here, we establish a multidimensional analy...

Synergistic Microwave–ZwitterionicNaturalDeep Eutectic Solvents System for Selective Fractionation of PineappleLeaf Agro-Biomass, Enabling Multifunctional Lignin and BioethanolProduction

Abstract This study introduces a novel, rapid, and sustainable biorefinery approach for lignocellulosic biomass valorization, employing a natural deep eutectic solvent (NADES) system composed of betaine hydrochloride and lactic acid (15:85 w/w). Within just 4 min of microwave-ass...

The Psychology Behind Beliefs in Ghosts and Spirits

This independent research paper examines the psychological and social factors that may contribute to beliefs in ghosts and spirits. Drawing on research from psychology and related fields, the paper explores how cognitive processes, thinking styles, personality characteristics, sl...

Challenges and barriers to musculoskeletal injury research in sub-Saharan Africa

Aims: Musculoskeletal (MSK) injuries are a major cause of morbidity and mortality worldwide. However, research into MSK injuries is hampered by significant challenges and barriers, particularly in low-and middle-income countries (LMICs). Our aim was to identify the most important...

Homologous knock-in processes facilitated by CRISPR-Cas9 in Aurantiochytrium and disrupting the gene for DNA ligase IV prevents transformation events

Abstract This study explores advanced molecular breeding techniques for Aurantiochytrium limacinum , a eukaryotic microorganism valued for its industrial production of DHA and astaxanthin. We first employed the CRISPR-Cas9 system to simultaneously disrupt two genes: crtIBY , a mu...

The first steps after paralysis: Immediate locomotor responses following electrically induced loss and recovery of neuromuscular function

Abstract In nature, animals must rapidly regain coordinated locomotion after neuromuscular injury, but the earliest compensatory strategies remain unknown. We addressed this gap using a chronic, implantable kilohertz electrical stimulation (KES) system to reversibly block tibial...

Copper-Catalyzed Divergent1,4-Polyhaloalkylcyanationof 1,3-Enynes

Abstract We report a switchable copper-catalyzed divergent 1,4-polyhaloalkylcyanation of 1,3-enynes to construct a series of polyhalogenated allenes with high chemoselectivity and regioselectivity. The 1,4-dichloromethylcyanation of 1,3-enynes is realized by merging aminoalkyl ra...

A needle-mounted guide for improving needle visualization during ultrasound-guided needle insertion: a simulation study in novice operators

Abstract Background In ultrasound-guided needle insertion, continuous needle visualization is crucial for accurate needle placement, particularly for beginners. Novice operators may have difficulty maintaining the spatial relationship between the needle trajectory and the ultraso...

Dark Matter as a Screening Artifact of 5D Spacetime Dynamics

We propose an alternative framework for galactic rotation curves and gravitational dynamics without invoking particle dark matter, formulated within a 5-dimensional Kaluza-Klein scalar tensor geometry. By introducing a force-density screening mechanism acting as a dynamical self-...

Enhancing iNKT cell immunotherapy through the integration of optimized CAR endodomains and iNKT engagers

Abstract iNKT cells are emerging as a highly promising immunotherapy platform for the treatment of cancer. To maximise the anti-cancer activity of CAR-iNKT against the blood cancer multiple myeloma we investigated optimal CAR designs and their combination with new iNKT-specific e...

SEQUENCES WITH INEQUALITIES

Abstract We consider infinite sequences of positive numbers. The connection between log-concavity and the Bessenrodt–Ono inequality has been the focus of several papers. It has applications in the white noise distribution theory and combinatorics. We improve a recent result by Be...

Symmetric rendezvous on unlabelled complete graphs below the Anderson–Weber constant: certified manuscripts, exact-rational certificates, Lean 4 formalization, and independent audit layer

This record contains two companion manuscripts on symmetric rendezvous on unlabelled complete graphs, together with their complete reproducibility supplement Paper I (upper bound) constructs a legal symmetric strategy with lim E[T_n]/(n−1) = 0.82887837309423433534… < c_AW = 0.828...

Fiber Singularity Theory A Unified Framework of Fractal Geometry, Quantum Chaos, and Riemann ζ Zeros

Classical mathematics treats singularities (poles, essential singularities, discontinuities, non-differentiable points) as signs of theoretical failure. However, physical systems—from turbulence and black holes to quantum energy levels—frequently exhibit such structures, suggesti...

Integrative genomic and functional analyses identify LjbZIP36 as a candidate regulator of β-carotene accumulation during floral color transition in Lonicera japonica

Abstract Background Floral color transition is a characteristic developmental process in Lonicera japonica , during which flowers gradually change from white to golden yellow during flower maturation owing to carotenoid accumulation. Although carotenoid biosynthetic genes have be...

TSUMS MAX-STACK Full Replay Engine v1.0 Final: A Public-Layer Governance Lifecycle Replay and Cross-Ledger Compilation Framework

TSUMS MAX-STACK Full Replay Engine v1.0 Final is a Public-Layer governance lifecycle replay and cross-ledger compilation framework. It compiles known facts, missing records, duty signals, decision nodes, accountability mappings, stop-loss points, evidence chains, ledger bridges,...

E‑Spacetime: A Noncommutative Entanglement Geometry Extending Einstein Gravity

E‑spacetime is a noncommutative geometry defined by [T,Si]=Θi, where time–space entanglement generates curvature. This framework unifies geometry, fields, gravity, and particles, and recovers GR, QFT, and Yang–Mills theory in the commutative limit.