Research works

ABCDscores: an R package for computing summary scores in the ABCD Study®

Abstract The ABCD Study® is the largest longitudinal research study of brain development and child health across the United States. The study generates a rich multimodal dataset, including file-based raw and derivative data and a curated tabulated dataset comprising data from a b...

The extreme diversity of retinal amacrine cells has deep evolutionary roots

Amacrine cells (ACs) comprise a heterogeneous class of inhibitory neurons in the vertebrate retina, exhibiting morphological and functional complexity rivaling that of cortical interneurons. Here, we integrate single-cell and single-nucleus transcriptomic atlases from 24 vertebra...

Lessons learned from a Kaggle challenge for particle picking in cryo-electron tomography

Abstract The difficulty of particle picking in cryo-electron tomography remains a barrier to routine in situ structure determination. Machine learning is well-suited to overcome this bottleneck with efficient algorithms that generalize across molecular species. To spur new algori...

From Neuropeptides to Toxins: Illuminating the Origins of Venom Complexity in Cone Snails

Abstract New genes and gene functions are key drivers of evolutionary innovation. Venomous animals, such as cone snails, provide striking examples of gene innovation, yet the mechanisms by which toxins arise remain poorly understood. Using the Conus textile genome, we uncover how...

Computer-Vision-Enabled Worker Video Analysis for Motion Amount Quantification

The performance of physical workers is significantly influenced by the extent and quality of their motions. However, accurately measuring and assessing these motions remains a challenge due to the limitations in conventional instrumentation; wearable sensors require calibration a...

Skuas as sentinels of high pathogenicity avian influenza H5N1 on the Antarctic Peninsula in the 2024/2025 austral summer

Despite Antarctica's geographic isolation, the first incursion of high pathogenicity avian influenza (HPAI) H5N1 was detected in the 2023/2024 austral summer. Surveillance for HPAI H5N1 in Antarctica remains patchy due to logistical, financial and infrastructure challenges, with...

Targeted neuromodulation of perceptual decision-making networks causally dissociates sensory and metacognitive performance

ABSTRACT Perceptual judgements and their subjective evaluation (i.e., metacognition) are considered tightly coupled aspects of decision-making. Yet, emerging evidence suggests that distinct neural mechanisms underlie these processes. In motion perception, studies have identified...

DQIS — Distributed Quorum-Based Independent Immune Surveillance: A Theoretical Framework for Byzantine Fault Tolerance for Multi-Channel Immune Surveillance

A mathematic model has been developed relating the drug sensitivity of a tumor to its own spontaneous mutation rate towards phenotypic drug resistance. The proportion as well as the absolute numbers of resistant cells will increase with time and the fraction of resistant cells wi...

Appendix A · The Factory: A Formal Paper Built From Its Contract, With No Module Written By Hand

A deterministic architecture engine declares software architecture as verifiable constraints and confronts them against real code. Since August 2026 it also builds: given a contract carrying structures, signatures and flow, its factory` plane produces the complete system, with an...

Creating a Digital Edition with Generative AI in a Seminar Setting

This short paper was presented at the TEI2026 conference in Vancouver on August 13, 2026. An HTML version of the slides published here as PDF is available at: https://hennyu.github.io/tei_26/#/ In the talk, the experiences of using GenAI to create a prototype of a Digital Scholar...

Sapience: A Hybrid Architecture for Long-Context Reasoning and Continual Learning

Frontier models approach long-context reasoning by scaling the transformer context window: one of the several memory systems the brain evolved, scaled alone. We present Sapience, a hybrid architecture that builds the missing ones: a substitutable transformer cortex coupled to hip...

A matrix-valued von Mangoldt measure in the finite Connes-van Suijlekom path

A matrix-valued von Mangoldt measure in the finite Connes-van Suijlekom path. Akiva Groskin, 2026. Manuscript (18 pages) and full reproducibility package. Fix a Galerkin level N in the finite Connes-van Suijlekom truncation of the Weil quadratic form (no archimedean cutoff) and v...

A finite Guinand-Weil dictionary and archimedean tail order for the truncated Weil quadratic form

We prove an exact finite dictionary from each real even finite Connes-van Suijlekom Galerkin coefficient vector to a band-limited Guinand-Weil test function: every value of the truncated Weil quadratic form is an exact sum over the nontrivial zeros of the Riemann zeta function. A...

Evolution, Not Revolution: A Manifesto for the Considered Reform of a Confident Nation

Version 6 is a reconciliation release. The set now comprises four documents that agree at the point of detail: The Manifesto, The Academic Précis, The Arithmetic, a fiscal companion that costs the programme in full, and a national Profit & Loss Statement and balance sheet model a...

Alkali Metal Ion Migration Modulation-Induced High-Performance Low-Temperature Solid Oxide Fuel Cells

Abstract Reducing the operating temperature while maintaining a stable performance is a key challenge for solid oxide fuel cells (SOFCs). Here, we improve the performance of low-temperature SOFCs by modulating the migration of alkali metal ions within the cell. To visualize the m...

AI Agent Memory Architectures: Episodic, Semantic, and Working Memory in Long-Horizon Tasks

Research article: AI Agent Memory Architectures: Episodic, Semantic, and Working Memory in Long-Horizon Tasks

A Fourth-Logarithmic-Derivative Inequality for the Riemann Xi Kernel

We prove a global fourth-logarithmic-derivative inequality for the positive even Riemann Xi kernel \[\Phi(x)=\sum_{n=1}^{\infty}\pi n^2\left(2\pi n^2e^{4x}-3\right)\exp\left(5x-\pi n^2e^{4x}\right),\] extended evenly to the real axis. Writing \[L(x)=\log\Phi(x),\] the main result...

Symmetric rendezvous on unlabelled complete graphs below the Anderson–Weber constant: certified manuscripts, exact-rational certificates, Lean 4 formalization, and independent audit layer

This record contains two companion manuscripts on symmetric rendezvous on unlabelled complete graphs, together with their complete reproducibility supplement Paper I (upper bound) constructs a legal symmetric strategy with lim E[T_n]/(n−1) = 0.82887837309423433534… < c_AW = 0.828...

Early functional reactivity to a CEACAM5 x CD3 T cell bispecific antibody in solid tumors associates with baseline immune contexture rather than target antigen density alone

Abstract Clinical translation of T cell bispecific (TCB) therapies in solid tumors is hindered by the immunosuppressive tumor microenvironment and intratumoral heterogeneity, features poorly captured by standard preclinical models. We applied an integrated translational framework...

Sex differences in neurogenic hypertension: estrogen modulation of NADPH oxidase signaling in the rostral ventrolateral medulla

Abstract Neurogenic hypertension is characterized by sustained sympathetic activation arising from dysregulation within the central autonomic network. The rostral ventrolateral medulla (RVLM) is a major sympathetic premotor region that integrates reflex, neurohumoral, inflammator...