Research works

PhenoDEL: A NovelScreening Strategy Based on IntracellularProtein Degradation Activity

Abstract Targeted protein degradation (TPD), including proteolysis targeting chimeras (PROTACs) and molecular glue degraders (MGDs), is a promising therapeutic approach. However, systematic discovery of such small molecules remains a major challenge. Here, we present PhenoDEL, a...

Uniqueness and nondegeneracy of positive solutions for a critical Choquard-Kirchhoff equation

In this paper, we investigate positive solutions of the critical Choquard–Kirchhoff equation :[Formula: see text] where [Formula: see text], [Formula: see text], [Formula: see text], and [Formula: see text] is the Hardy–Littlewood–Sobolev critical exponent. We first classify posi...

The effect of organic amendments on cannabidiol yield and topsoil health (0–10 cm) in floral hemp (Cannabis sativa L.) production system

Abstract Background Compost and cover crops enhance soil health and crop productivity in agricultural systems, yet their integration as soil management strategies in floral hemp ( Cannabis sativa L.) production remains underexplored. Understanding these effects is critical for op...

Comparative evaluation of matrix systems on proximal contact strip force and surface geometry in class II direct composite restorations: an in vitro study

Abstract Background Proximal contact strip force and surface geometry remain challenging in Class II composite restorations, with matrix system selection being a key factor. This study aimed to compare the proximal contact strip force and surface geometry of the myQuickmat Classi...

Is Free-Energy Minimisation a Generative Principle or a Privileged Representation of Self-Maintaining Dynamics?

The free energy principle (FEP) is used both as a representation of organised dynamics and as a candidate account of the mechanisms that produce them. We separate these claims in artificial systems whose controllers were specified by proportional–integral–derivative control, rewa...

The Open-Data Appendix (The Receipts Ledger)

This open-data appendix compiles the raw empirical receipts and comprehensive interaction logs verifying Case Study 6 of 6. Serving as the primary data ledger for a live public discourse audit (N = 214), this document archives the exact textual outputs generated by digital forum...

E‑Spacetime: A Noncommutative Entanglement Geometry Extending Einstein Gravity

E‑spacetime is a noncommutative geometry defined by [T,Si]=Θi, where time–space entanglement generates curvature. This framework unifies geometry, fields, gravity, and particles, and recovers GR, QFT, and Yang–Mills theory in the commutative limit.

Spectral Properties and Localization Barriers of Co-occurrence Gram Matrices in Set Families

In this paper, we establish the spectral framework governing $G = V^T V$ for arbitrary $0\text{-}1$ matrices. Combining Rayleigh-Ritz variational bounds with Gershgorin disk localization, we prove a general spectral inequality relating element frequencies to local average set siz...

The Psychology Behind Beliefs in Ghosts and Spirits

This independent research paper examines the psychological and social factors that may contribute to beliefs in ghosts and spirits. Drawing on research from psychology and related fields, the paper explores how cognitive processes, thinking styles, personality characteristics, sl...

ELLS–NSBA three-stage framework for optimal DG/SC placement and EV integration in distribution networks

The growing penetration of distributed generation (DG), shunt capacitors (SC), and electric vehicles (EVs) in distribution networks demands optimal siting strategies that balance operational efficiency and structural resilience. Existing metaheuristic approaches treat every bus a...

Crocetin HaltsTumorigenesis in Metastatic BreastCancer via Disrupting CYP2J2/EET Axis

Abstract CYP2J2 catalyzes the conversion of arachidonic acid into epoxyeicosatrienoic acids (EET), which have gained significant attention due to their oncogenic properties. Differential overexpression of CYP2J2 in tumors results in increased EET production. The role of EET in tu...

Dark Matter as a Screening Artifact of 5D Spacetime Dynamics

We propose an alternative framework for galactic rotation curves and gravitational dynamics without invoking particle dark matter, formulated within a 5-dimensional Kaluza-Klein scalar tensor geometry. By introducing a force-density screening mechanism acting as a dynamical self-...

The Curve Is an Average of Worlds: What Partial Dependence Actually Shows

Partial dependence plots are often interpreted as direct response curves: set a feature to a value, average the predictions, and read the resulting line as an explanation. This paper evaluates a narrower object. A marginal partial-dependence curve averages a frozen predictive mod...

Your Insured's AI Agent Caused the Loss: Was It Authorized to Act?

This paper examines a developing insurance problem created by autonomous and semi-autonomous AI agents: when an insured deploys an AI agent that causes a financial, operational, contractual, cyber, or physical loss, who bears responsibility and how should insurers evaluate the re...

WINNEX: Weighted Inference Neural Network Enhancement — A Deterministic, Training-Free Framework for Enhancing Pretrained Language Models (Composition of the Winnex Spectral Tokenizer, X-Factor Manifold Projector, and Madhava Bound Engine)

This document is the pre-patent technical specification for WINNEX — Weighted Inference Neural Network Enhancement — a deterministic, training-free framework that enhances a pretrained language model without modifying its weights or running any gradient step. The framework compos...

Critical Pedagogy of Multicultural Incorporation

Abstract This article brings cultural sociology, civil sphere theory, and critical theory into dialogue to examine the empirical-cum-political stakes of education in multicultural societies. Using a mixed-methods approach, it analyzes school cultures in Finland, Scotland, and Swe...

Sella turcica dimensions in patients with severe skeletal malocclusion using cone-beam computed tomography: a retrospective observational study

Abstract Background As traditional two-dimensional cephalometric analyses of skeletal malocclusions often fail to capture complex craniofacial variations. Recent advances in three-dimensional (3D) imaging have highlighted the correlation between sella turcica morphology and skele...

Clinical outcomes of bleomycin electrosclerotherapy (BEST) for the treatment of slow-flow vascular malformations (SFVMs): a UK single-centre experience

BACKGROUND: Bleomycin Electrosclerotherapy (BEST) is an emerging treatment for slow-flow vascular malformations (SFVMs), utilising electroporation to enhance intralesional bleomycin uptake. This study evaluates the safety and clinical outcomes of BEST in reducing symptom severity...

A novel stiffness-distribution-controlled hybrid locking compression plate for osteoporotic midshaft clavicle fractures: a finite element study

Abstract Background Fixation of osteoporotic midshaft clavicle fractures in elderly patients requires a careful balance between mechanical integrity and anatomical compatibility. Conventional single-diameter locking plate systems present an inherent trade-off, as larger plates pr...

Oxidative Stressafter Pollutant Exposure DependsStrongly on Experimental Design and Pollutant Properties in Annelids:A Meta-Analysis

Abstract Measurements of oxidative stress are often performed to assess a species’ general sublethal stress response to a pollutant. However, oxidative stress bioassays often produce seemingly ambiguous results, and the drivers that lead to these differences are largely unknown....