Research works

Ovarian cancer tumor immune microenvironment and its clinical trial implications

Abstract Ovarian cancer is the most lethal gynecologic malignancy, primarily because of late-stage diagnosis, rapid disease progression, and marked molecular and immunologic heterogeneity. It remains the leading cause of gynecologic cancer-related death, affecting approximately 1...

Platform-Enabled People Governance (PEPG): A Problem-Centered, Platform-Enabled Model for Distributed Public Governance

This paper proposes Platform-Enabled People Governance (PEPG), a conceptual model of public governance organized around public problems rather than around a single institution, bureaucracy, or digital platform. PEPG places a public problem at the center and connects citizens, exp...

Application of Deep Learning for Pavement Monitoring: Movement towards Autonomous Future

Pavements are essential elements of transportation networks and are instrumental to the growth and development of a country. To harness the full potential of this infrastructure, it is necessary to maintain it in proper structural and functional conditions. Conventional technique...

MSSARN - multi-layer spectral-spatial attention based residual network for HSI classification

Abstract Hyperspectral imaging (HSI) presents several challenges in remote sensing, particularly in classification tasks. One significant challenge is the high dimensionality of HSI data, which includes hundreds of spectral bands. Another challenge is the spectral-spaatial comple...

A mechanistic approach about oxidative, mutagenic, and cytotoxic effects of an organotellurane

Abstract Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic acti...

Response of the replisome to araA and araC suggests a mechanism for arabinosyl nucleoside tolerance

Arabinosyl (ara) nucleoside analogues such as vidarabine (araA) and cytarabine (araC) are antimetabolites known to inhibit DNA polymerases in isolation. However, their effects on DNA synthesis catalysed by the multi-protein replisome remain unknown. Here, we uncover a central rol...

Associations between physical activity levels and socioeconomic and occupational factors among a large workforce population: insights from an employee health cohort study

Abstract Background Physical inactivity is a growing concern among working populations, with implications for health and productivity. Unlike most previous studies, this research draws on large-scale cohort data from Iranian employees to examine the associations with socioeconomi...

SIRT3 determines the sensitivity of cancer cells to mitochondrial targeting

Abstract SIRT3 is a mitochondria-localized member of the sirtuin family, playing a key role in cellular antioxidant defense. Its function in carcinogenesis and therapy response remains uncertain. In the present study, we sought to identify the role of SIRT3 in regulating cell dea...

The Buddhadasa Indapanno Archives Knowledge Graph: an Open RiC-O 1.1 Dataset from a Thai Buddhist Archive

Data paper. We publish the archival description of the Buddhadasa Indapanno Archives (BIA, Bangkok) as an open dataset conforming to the International Council on Archives' Records in Contexts Ontology (RiC-O) 1.1: 97,852 triples describing 3,728 records, 1,088 record sets, 1,995...

High-throughput screening and mechanistic insights into solid acid proton conductors

Abstract Proton-conducting solid acids could enable water-free operation of high-temperature fuel cells. However, systematic materials screening has, hitherto, been computationally prohibitive. Here, we introduce a two-stage high-throughput screening strategy that directly comput...

Palynology of Bathonian macroflora-bearing beds from NW-Jordan – expanding a rare ‘peephole’ into Middle Jurassic palaeotropical vegetation

Abstract A diverse and well-preserved sporomorph assemblage was recovered from the Middle Jurassic (Bathonian) marine Arda Formation in Jordan. The recorded palynomorphs originated from macroflora-rich layers that primarily represent a bennettitalean-fern community. This finding...

Pilot study comparing the effects of high dose THC to high dose psilocybin and placebo in the set and setting of a classic psychedelic therapy session

RATIONALE: Delta-9-tetrahydrocannabinol (Δ9-THC) has been reported to evoke psychedelic-like experiences at high doses in some individuals. However, the doses of Δ9-THC that occasion such effects and the phenomenology of these experiences are poorly understood. OBJECTIVES: This b...

Study on the joint application of multi-database to improve the ability of high-throughput sequencing of forensic diatoms

Objective: to apply the method of single or combined use of multiple databases to improve the accuracy of diatom classification based on high-throughput sequencing and to strengthen the accuracy of diagnosis and inference of drowning location of corpses in forensic practice. Meth...

Biological Restriction: A Foundational Operator in Early Development

Biological Restriction: A Foundational Operator in Early Development introduces biological restriction as a primitive developmental operator that governs the emergence, coherence, and vulnerability of early embryonic systems. Classical developmental biology explains pattern forma...

Microbial decomposition of organic matter in a constructed wetland designed for metal retention

Abstract Metal contaminants threaten water resources and constructed wetlands can retain them using microbial processes that are supported by organic compounds. However, organic compounds also form transient metal complexes. To determine how microbial communities from a construct...

Hotspot to Homogeneous: Amorphous Interfacial Current Redistribution Enables Stable Solid-State Lithium-Metal Batteries

Abstract Interfacial instability in oxide ceramic electrolyte (OCE)-based solid-state lithium metal batteries (SSLMBs) is conventionally attributed to chemical incompatibility or mechanical failure, yet the underlying atomic-scale mechanisms remain elusive. Here, we reveal that g...

The Mother Nature Programme: a single-arm mixed-methods feasibility study of a group nature-based intervention for mothers experiencing postnatal mental health difficulties and their infants

Abstract Background Postnatal mental health difficulties are common and often under-treated. Nature-based interventions have potential mental health benefits, but little research has focussed on their applicability postnatally. This study examined the acceptability and feasibilit...

#RSAA2026 Identification of Key Hub Genes in Hepatocellular Carcinoma via Integrated Bioinformatics Analysis and Stringent PPI Network Filtering

Hepatocellular Carcinoma (HCC) remains one of the most aggressive malignancies with complex molecular mechanisms. This study aims to identify key hub genes involved in HCC progression through an integrated bioinformatics approach. The datasets were retrieved from the Gene Express...

Mira Genesis II: When an Acquired Improvement Makes Things Worse — Bounded Machinery Self-Modification and the Limits of Its Transfer

Mira Genesis II reports the M107–M112 research sequence of the Mira Genesis project, extending earlier work on persistent cumulative capability acquisition toward the machinery that performs acquisition itself.Across a series of frozen, auditable experiments, the lineage first ac...

Scoping review of the environmental conditions under which cold injuries occur: study protocol

Aim: to map the peer-reviewed literature on associations between meteorological conditions and cold injuries and the exposures studied. Research Question: What meteorological conditions have been investigated in relation to cold injuries and what associations have been reported w...