Research works
The research papers we track — the newest first. Works with a plain-language summary link to it.
78103 work(s)
- BiologyOpen access
De novo design of RNA pseudoknots with deep learning
RNA design has been hindered by the limited accuracy of 3D structure prediction. Here, we show that intricate RNA structures can be generated with current deep learning tools through accurate de novo design of pseudoknot secondary structures. In an Eterna competition involving 57...
- Society & EconomicsOpen access
Abstract Pupil diameter reflects not only reflexive responses to light but also spontaneous fluctuations in arousal. Such pre-stimulus fluctuations may shape visual performance, yet it remains unclear whether they only affect perceptual sensitivity or decision processes in near-t...
- BiologyOpen access
Antidepressant prescribing and autism diagnoses have increased in recent years. We aimed to describe and compare trends in antidepressant prescribing, indications, doses and durations in autistic and non-autistic males and females in the United Kingdom (UK) from 1997 to 2023. Usi...
- Engineering & TechnologyOpen access
Development of a Chip-Scale Optical Gyroscope with Weak Measurement Amplification Readout
The design of an integrated optical chip is proposed containing a rotation sensing ring resonator (optical gyroscope) coupled to an inverse weak value amplified Sagnac interferometer that amplifies the signal containing the phase information. We show that, for conservative parame...
- Health & MedicineOpen access
Abstract Background Staphylococcus aureus prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments don’t exist. Understanding the human T cell response to chronic S. aureus osteomyelit...
- BiologyOpen access
Photocatalytic proximity labeling for the identification of G-quadruplex DNA-interacting proteins
Abstract DNA–protein interactions play an essential role in fundamental cellular biological processes. Herein, we report a photocatalytic proximity labeling approach for the broad screening of G-quadruplex (G4)-interacting proteins (G4IPs) using human telomere G4 DNA modified wit...
- BiologyOpen access
Why variant effect predictors and multiplexed assays agree and disagree
Abstract Computational variant effect predictors (VEPs) and multiplexed assays of variant effect (MAVEs) are two key tools for assessing the functional consequences of genetic variants. While their outputs are often concordant, there are also many differences. Here, we analyse mi...
- Health & Medicine
A necroptotic-to-apoptotic signaling axis underlies inflammatory bowel disease
ABSTRACT Inflammatory bowel disease (IBD) is a chronic condition caused by altered cytokine signaling, maladaptive immunity, dysbiosis, and intestinal barrier dysfunction. Patients with IBD receive therapy to correct these imbalances and achieve remission. However, most patients...
- Physics & SpaceOpen access
Episodic super-Eddington accretion as a clue to Overmassive Black Holes in the early Universe
Abstract Early JWST observations are providing growing evidence for a ubiquitous population of accreting supermassive black holes (BHs) at high redshift, many of which appear overmassive compared to the empirically-derived local scaling relation between black hole mass and host g...
- Health & Medicine
AIM: The "2026 Guidelines for Adult Stroke Rehabilitation and Recovery" replaces the 2016 "Guidelines for Adult Stroke Rehabilitation and Recovery." This updated guideline is intended to provide a comprehensive, up-to-date, evidence-based set of recommendations. The intended audi...
- BiologyOpen access
All-optical multimodal mapping of single-cell-type-specific metabolic activities via REDCAT
Abstract Metabolism is fundamental to cell function, yet its activities vary across tissue environments. Resolving these processes in situ at single-cell resolution is crucial for understanding physiology in health and disease. However, existing methods lack biochemical specifici...
- Engineering & TechnologyOpen access
Abstract This paper addresses the NP-hard problem of optimizing container handling at ports by integrating Quay Crane Dual-Cycling (QCDC) and dockyard rehandle minimization. We identify critical inter-dependencies between the unloading sequence of QCDC and the dockyard container...
- BiologyOpen access
SGLT2 inhibitors activate pantothenate kinase in the human heart
Abstract Inhibitors of sodium glucose cotransporter-2 (SGLT2i) demonstrate strong symptomatic and mortality benefits in the treatment of heart failure but appear to do so independently of SGLT2. The relevant pharmacologic target of SGLT2i remains unclear. We show here that SGLT2i...
- Physics & SpaceOpen access
This paper evaluates an uncrewed pathfinder mission architecture built by synthesizing seven prior conceptual frameworks. We ask a specific question: if the propulsion gap identified in the Phase-Managed Handover System (PMHS) and Powered Sundiver with Distributed Capture (PSDC)...
- Society & EconomicsOpen access
This paper proposes Platform-Enabled People Governance (PEPG), a conceptual model of public governance organized around public problems rather than around a single institution, bureaucracy, or digital platform. PEPG places a public problem at the center and connects citizens, exp...
- BiologyOpen access
Response of Tetranychus urticae (Acari: Tetranychidae) to natural products
Abstract The two-spotted spider mite, Tetranychus urticae (Acari: Tetranychidae), is a cosmopolitan pest of numerous crops, including grapevines, where outbreaks cause leaf chlorosis, necrosis, defoliation, and yield reduction. Intensive use of synthetic acaricides has led to res...
- Health & MedicineOpen access
Abstract Objectives To examine associations between food choice motives and diet quality in Korean adults and whether these associations vary by sex and age. Methods We analyzed cross-sectional data from an online survey of adults aged 20–64 years in Korea ( n = 1,829). Food choi...
- AI & ComputingOpen access
Oversubscribing One TEE: 512 Registered Tenants, a 1.22× Gain, and Isolation at 0.54 Percent
One confidential GPU serves a limited number of concurrent tenants. This reportmeasures what happens when registration exceeds that number: idle tenants'key-separated KV state is parked to disk and revived on activation, on an AzureH100 confidential instance with SEV-SNP active a...
- Society & EconomicsOpen access
Abstract Background Mental health symptoms may be linked to cognitive and social functioning in school-aged children, but less is known about whether these associations differ across migration-background groups. Methods We examined cognitive, social, and mental health measures am...
- Society & EconomicsOpen access
BIT-LMIND-BMS-001-F6-R1-TC — Independent-Research Terminal Closure and Public Handoff
Terminal independent-research checkpoint for the BIT Living Mind Body-Mind-Soul formal architecture. The deposit freezes the exact F3.3-to-F6-R1 lineage, scoped analytic and finite executable evidence, six unresolved external/Lean gates, a complete Host-2/Lean handoff capsule, an...