Research works

Naïve adaptive immune receptor repertoires in celiac disease assessed by machine learning; impact of the HLA-DQ2.5 allotype on the TCR repertoire

Abstract The adaptive immune receptor repertoire (AIRR) - the collection of an individual’s B-cell and T-cell receptors (BCRs and TCRs, respectively) - encodes cumulative immune history and is shaped by both germline genetics and environmental exposures. Skewed repertoires have b...

Open-Source AI in Government: Procurement Barriers and Adoption Patterns in Public Sector

Research article: Open-Source AI in Government: Procurement Barriers and Adoption Patterns in Public Sector

Sociodemographic and Clinical Factors Associated With Nirsevimab Receipt Among Children Aged Younger Than 20 Months in the New Vaccine Surveillance Network in 2023 to 2025

OBJECTIVES: We aim to evaluate the association of sociodemographic and clinical factors with nirsevimab receipt among children with medically attended acute respiratory illness (ARI) across multiple seasons and beyond birth hospitalization. PATIENTS AND METHODS: We included nirse...

Biological Restriction: A Foundational Operator in Early Development

Biological Restriction: A Foundational Operator in Early Development introduces biological restriction as a primitive developmental operator that governs the emergence, coherence, and vulnerability of early embryonic systems. Classical developmental biology explains pattern forma...

Silent Witnesses, Protective Bonds: Sibling Memories and Shielding Behaviors in Households Affected by Intimate Partner Violence

Abstract Purpose This exploratory qualitative study examines how adult siblings who identify as Latine make meaning of childhood exposure to intimate partner violence (IPV). The study explores how siblings protect one another, interpret violence, and carry these relational practi...

ClusterAttention: A training-free speedup of bidirectional attention

This paper introduces ClusterAttention, a general training-free speedup of bidirectional attention layers. Existing sparse attention methods either rely on structure in the input, such as order in language or spatial proximity in images, or use slow clustering processes amortized...

Higher postpartum α-defensin secretion is associated with diet during pregnancy and lower intensity of negative maternal mood

Abstract Perinatal anxiety and depression are serious concerns for many mothers. However, current early-phase community-based care is not always sufficient to prevent their aggravation, necessitating self-care approaches through daily habits that lower social and psychological im...

BIT-LMIND-BMS-001-F6-R1-TC — Independent-Research Terminal Closure and Public Handoff

Terminal independent-research checkpoint for the BIT Living Mind Body-Mind-Soul formal architecture. The deposit freezes the exact F3.3-to-F6-R1 lineage, scoped analytic and finite executable evidence, six unresolved external/Lean gates, a complete Host-2/Lean handoff capsule, an...

The 24-Cell Is a Gate Group: How the Binary Tetrahedral Structure Governs What a Qubit Can and Cannot See

The Watabe-Claude Method reads a signal's structure by assigning 4D-embeddedwindows to the 24 vertices of the 24-cell and decomposing the occupancy with thegroup B4. This note takes the 24-cell the other way -- into a qubit. Its 24vertices, as unit quaternions, are exactly the bi...

Patient Portal Use and Care Utilization Among Hospitalized Children

OBJECTIVE: Patient portals allow patients and caregivers to better engage with health care. Disparities in portal use among high-risk populations, like hospitalized children, could limit their benefits. Additionally, little is known about the association between pediatric portal...

The isolated HEPN domain of SACSIN exhibits RNA-binding activity

Abstract Autosomal Recessive Spastic Ataxia of Charlevoix–Saguenay (ARSACS) is a neurodegenerative disorder caused by mutations in the SACS gene, though the molecular function of its protein product, SACSIN, remains elusive. Therapeutic strategies for ARSACS are limited, mostly d...

clinical utility of whole genome sequencing in prenatal diagnosis

whole-genome sequencing, prenatal diagnosis, turnaround time, fetal anomalies, clinical utility, dynamic phenotype, whole-exome sequencing, chromosomal microarray analysis

Enzyme-Detergent and Detergent-Detergent Protocols for Human Urethra Decellularization: A Histological and Ultrastructural Study

Abstract Background and Objectives Decellularization of the human urethra produces extracellular matrix (ECM) bioscaffolds with strong potential for reconstructive urology, yet no standardized protocols exist for either cell removal or scaffold characterization. Histological asse...

Real-rootedness, palindromicity, and gamma-positivity of antichain polynomials for [2] x [m] x [n]

For all positive integers m and n, this manuscript proves that the antichain generating polynomial of [2] x [m] x [n] has only negative real zeros. It also proves that the polynomial is palindromic exactly when |m-n|=1, and that every gamma coefficient is strictly positive in pre...

Dual General Position in Lexicographic Products with a Complete First Factor

Let G be a nonempty finite simple graph. For every m ≥ 2, we prove gp_d(K_m ∘ G) = m q_2(G), where q_2(G) is the maximum size of a set A ⊆ V(G) for which both G[A] and G[V(G) ∖ A] are complete, and set q_2(G) = 0 if no such set exists. This resolves a previously posed problem con...

Genome-wide association study of the cecal microbiota revealing novel genetic insights into lipid deposition

Abstract Background Lipid deposition is a critical indicator of the economic and nutritional value of animal products. Among various regulatory factors, the cecal microbiota has been recognized as an important effect influencing lipid deposition capacity in tissues such as skin f...

Virus-like particle display of consensus α-neurotoxins does not enhance neutralising antibody responses against elapid venoms

Snakebite envenoming is a neglected tropical disease, with neurotoxic elapid venoms in particular posing a major therapeutic challenge due to the rapid action and inter-species diversity of α-neurotoxins. Consensus toxin approaches have emerged as a promising strategy for generat...

Titanium dioxide/zinc telluride/aluminium antimonide-assisted label-free plasmonic sensor for early detection of glucose in urine

Abstract The article presents a high multi-layered surface plasmon resonance (SPR) sensor for the detection of glucose in urine. This designed sensor consists of a K108 (LZOS) prism, a silver (Ag) layer, and dielectric layers of titanium dioxide (\(\:{TiO}_{2}\)), zinc telluride...

U-Net-based hybrid framework for accelerating deterministic rough-surface mixed lubrication simulations

Abstract Despite significant advances in deterministic mixed lubrication modelling, the computational complexity of these simulations remains prohibitive, limiting their practical use in rapid analysis and design optimisation. This study addresses this bottleneck by developing a...

Intermuscular Fusion Between the Psoas Major and Iliacus Muscles: Anatomical and Histological Study

Abstract Introduction The term iliopsoas has recently been questioned because some anatomical studies have revealed that the psoas major and iliacus have separate distal insertions. Additionally, some older references mention a more proximal intermuscular fusion. Therefore, the a...