Research works

Melatonin Alleviates Saline–Alkali Stress in Pakchoi by Protecting Photosynthetic Electron Transport, Ion Homeostasis, and Antioxidant Defense

Saline–alkali stress severely restricts leafy vegetable growth by impairing photosynthesis, ion homeostasis, and oxidative balance. This study investigated whether exogenous melatonin could alleviate saline–alkali stress in pakchoi (Brassica rapa subsp. chinensis) through coordin...

Comparative genomic analysis reveals distinct population structure in Legionella anisa

Abstract Legionella anisa has been frequently isolated from engineered water systems; however, its population structure remains understudied compared to Legionella pneumophila. Here, we generated complete genome sequences for four L. anisa isolates recovered from a healthcare fac...

Verifying Interrupt-driven Programs Efficiently via Heuristic and Reduced Partial-order Constraints

Interrupt-driven programs are extensively utilized in embedded systems for safety-critical domains. However, uncertain interleaving executions of enabled tasks with different priorities often lead to concurrency defects. In this context, assertion violation detection is a fundame...

Antibiotic pretreatment with ampicillin or streptomycin differentially shapes Salmonella infection kinetics and associated intestinal inflammation in mice

Salmonella enterica serovar Typhimurium (S. Tm) mouse infection models commonly rely on antibiotic pretreatment to disrupt microbiota-mediated colonization resistance and enable reproducible infection. Streptomycin is the primary antibiotic used, but alternative pretreatment regi...

Limiting dengue transmission using a differential game approach

In this paper, a fundamental structural asymmetry in dengue fever epidemic control approaches is identified and formalized. We show that treatment and quarantine interventions must influence the sick compartment, whereas the majority of epidemic game models treat interventions as...

Longitudinal Data from a Large, Multi-Target Stool DNA Colorectal Cancer Screening Program

Background & Aims: Multi-target stool DNA (mt-sDNA) is an established stool-based colorectal cancer screening test, yet long-term performance is not well-described. We evaluated follow-up colonoscopy rates & quality, neoplasia yield, and repeat-testing adherence over 10 years wit...

Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice

Background Most mutations causing hypertrophic cardiomyopathy (HCM) affect sarcomeric proteins. Mutations in junctophilin-2 (JPH2) are also implicated, but the underlying mechanisms remain unclear. An A405S variant in JPH2 was identified in a male adolescent patient with interven...

Mental Health and Psychological Constructs Related to Performance in Professional, Semi-Professional, and Competitive Adolescent Women’s Soccer Players: A Scoping Review

Background: Mental health has become a fundamental component of the sports world. Although previous studies have addressed psychological aspects of women’s soccer, no comprehensive review has mapped both mental health symptoms and adaptive psychological resources and psychophysio...

IL-22 Increases Proglucagon-expressing Enteroendocrine Cells via STAT3 in Human iPSC-derived Intestinal Epithelium

Intestinal epithelial differentiation is tightly regulated to maintain tissue homeostasis and systemic metabolic function. Although the intrinsic transcriptional programs governing enteroendocrine cell (EEC) development have been characterized extensively, the role of extrinsic i...

A new inquiry into the fundamental module of Sui-Tang Luoyang layout based on compositional proportions

Abstract Sui-Tang Luoyang was an international metropolis in the 7th–10th centuries. The 50- zhang unit has long been regarded as the fundamental module for the layout design of this capital. Taking the Danei as the benchmark, this study determines the modular relationships acros...

Computational Explorations of Constrained $SO(3,3)$ Spacetimes: Part I. Visualizing the Curvature Singularity and Topological Solitons

Numerical and visual verifications of the constrained SO(3,3) multitemporal spacetime framework are presented in this paper. While heavy lattice simulations are constrained by hardware limitations, this study employs accessible, low-dimensional computational toy models to graphic...

From Electrochemical Gradients to Informational Sequences: A Theoretical Framework for the Origin of Life

This document presents a unified theoretical framework tracing a step-by-step pathway from pre-biotic electrochemical chemistry to the emergence of informational sequences capable of hereditary transmission. Rather than treating RNA as a starting point, it identifies a hierarchy...

Strategic Management of Autonomous Drone Systems: Value Creation, Organizational Capabilities, and Ecosystem Readiness

Autonomous systems are now transitioning from R&D into business assets. When autonomous systems-intelligent machines are combined with sensors, AI, networking and autonomous logic, the machines can execute physical tasks with a degree of autonomy from direct human control. The pa...

Prevalence and characteristics of colonic diverticulosis: a retrospective cross-sectional study in Southern China

Abstract Background Recent literature indicated that the prevalence of colonic diverticulosis in China is increasing. However, there is limited information on colonic diverticulosis in China. Our study aims to determine the prevalence and characteristics of colonic diverticulosis...

A Dimensionless Similarity Framework for Organic Rankine Cycles: Generalized Performance Maps and Reduced-Pressure Optimality

Organic Rankine Cycles (ORCs) have become one of the most promising technologies for converting low- and medium-grade waste heat into useful power. However, conventional ORC analyses are typically performed using dimensional variables and application-specific operating conditions...

Ageing processes in the bonobo gut microbiome mirror human patterns

Ageing is associated with changes in the human gut bacterial microbiome: with age, it becomes more diverse, intra- and interindividual variability increases and it shows a decline in core bacterial genera and an expansion of rarer genera. While recent evidence in model organisms...

Optical Coherence Tomography‐Guided Directional Coronary Atherectomy Using Tip‐Detection Method

ABSTRACT Directional coronary atherectomy (DCA) requires precise spatial orientation. Although the tip detection method is established for intravascular ultrasound, its application in optical coherence tomography (OCT)‐guided DCA remains unestablished. We present a case of functi...

Chaperone-assisted selective autophagy (CASA) in polyglutamine-related diseases: From mechanisms to therapeutic perspectives

Chaperone-assisted selective autophagy (CASA) is a crucial process aimed at maintaining proteostasis in several neurodegenerative diseases associated with protein misfolding, including polyglutamine (polyQ) diseases. Autophagy is a critical lysosome-mediated degradation pathway,...

Outcome of myoconjunctival enucleation in Bangladesh

Objectives: To evaluate the implant motility of myoconjunctival enucleation with polymethyl methacrylate (PMMA) implant, compared to the conventional enucleation with muscle imbrication with PMMA implant, and also to that of enucleation with porous polyethene implant. Material an...

When genotype precedes phenotype: incidental findings in inherited disorders of hemostasis

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