Research works

Recasting Caste: An Investigation of Social Reproduction of Jatt Dominance in Punjab

ABSTRACT In principle, Sikhism is considered as a casteless religion but this paper attempts to explore the significant presence rather dominance of a caste identity, that is, Jatts in Sikh religion. This is carried out through a longitudinal appraisal of the status of this caste...

Macroporous Poly(hydroxyethyl methacrylate) Hydrogels as Removable Antibiotic-Capture Liners for Endotracheal Tubes Designed to Prevent Ventilator-Associated Pneumonia

Ventilator-associated pneumonia (VAP) is a life-threatening condition most frequently associated with the use of endotracheal tubes (ETs). This study describes the development of macroporous p(HEMA) hydrogels as removable antimicrobial liners for ETs to help prevent VAP. Hydrogel...

Beyond Suitability: Mapping Current and Projected Conservation Gaps for Three Rare Pheasants in Karst Landscapes of Southwest China

Climate-driven range shifts may create new environmentally suitable areas, but whether these areas provide favourable habitat conditions or adequate protection remains poorly understood. We assessed conservation gaps for three rare pheasants (Syrmaticus humiae, S. ellioti and S....

Paired Whole-Genome Sequencing of Scalp Angiosarcoma and Matched Lung Metastasis Reveals Common Clonal Origin and Lung-Specific Evolution

Background and Clinical Significance: Cutaneous angiosarcoma frequently metastasizes to the lungs, where it may rarely present as diffuse cystic lung disease with recurrent pneumothorax, resulting in substantial diagnostic difficulty. We report a case of pulmonary metastatic cuta...

Varying Cancer Drug Doses to Balance Tumor Control and Resistance Evolution

The effectiveness of any cancer therapy depends on its dose and its treatment schedule. A potential third dimension of regimen design is whether intentional fluctuations in administered dose might improve treatment outcomes. In this issue, West and colleagues demonstrate that dos...

Hemorrhage Volume and Imaging Recommendations: Factors for Decision Making in the Care of Patients With Perimesencephalic Subarachnoid Hemorrhage

BACKGROUND AND OBJECTIVES: Perimesencephalic subarachnoid hemorrhage (pmSAH) has a markedly better prognosis than aneurysmal subarachnoid hemorrhage. Despite advances in noninvasive imaging, the role of repeat digital subtraction angiography (DSA) after negative initial high-qual...

Comprehensive evaluation of the αβ-TCR repertoire profile in hepatitis B vaccine-positive responders and patients with chronic hepatitis B

T cells play a vital role in hepatitis B virus (HBV) infection, mediating both protective immunity and immunopathology. Deep profiling of the T cell receptor (TCR) complementarity-determining region 3 (CDR3) provides critical insights into T cell composition and function. However...

Functional Brain Network Alterations Linked to Cancer-Related Cognitive Impairment in Breast Cancer Patients

Abstract Background Life expectancy for cancer patients has improved due to new therapies, but many survivors experience long-lasting side effects, including cancer-related cognitive impairment (CRCI). CRCI symptoms—such as difficulties with attention, memory, processing speed, f...

Territorial Dynamics and Historical Trajectory of Community Forest Management in San Pedro el Alto, Oaxaca

The transformation of forest landscapes is driven by complex socioecological dynamics. This research analyzes territorial transitions in the Zapotec indigenous community of San Pedro el Alto, Oaxaca, Mexico, from 1997 to 2021, linking vegetation cover changes with the consolidati...

mTORC1 Promotes SARS-CoV-2 Replication and Attenuates Type I Interferon Responses in the Alveolar Epithelium: A Computational and Experimental Study

Abstract The mechanistic target of rapamycin complex 1 (mTORC1) has been implicated in coronavirus pathogenesis, yet its precise role in shaping antiviral defenses in pneumocytes remains unresolved. This study combines ex vivo human lung tissue assays with a literature-curated, l...

Correlation Between CT Manifestations and Treatment Strategy in Nasal Bone Fractures

Objective: To determine the association between detailed CT manifestations of nasal bone fracture and treatment strategy, emphasizing whether CT-derived structural severity can stratify conservative treatment, closed reduction, and open reduction/septorhinoplasty. Methods: This r...

Do Normal Early Ultrasound Findings Predict Normal Acetabular Development? A Study of Late-Presenting Dysplasia in Graf Type I Hips

Background: Developmental dysplasia of the hip (DDH) is increasingly recognized as a dynamic condition that may evolve after birth. This study aims to evaluate the natural history of hips with normal or borderline findings on early ultrasound and to identify imaging features asso...

Structural variation landscape reveals phenotypic divergence across cocoa populations

Abstract Structural variations (SVs) represent an important source of genomic diversity and can contribute substantially to phenotypic variation in crops. However, the population-scale distribution and phenotypic effects of SVs in Theobroma cacao L. (cocoa) remain poorly understo...

How Does Inter-Epitope Spacer Variation Within Artificial Immunogens Based on T-Cell Epitopes of Tick-Borne Encephalitis Virus Affect Immunogenicity?

Background/Objectives: In recent years, researchers have directed considerable attention toward the activation of the T-cell response in the development of vaccines against viral infections, including the tick-borne encephalitis virus (TBEV). A particularly promising approach to...

Evaluating pharmacological targeting of actin regulatory pathways during aging in C. elegans

Abstract Actin is a highly conserved cytoskeletal protein that regulates numerous cellular processes essential for tissue homeostasis and healthy aging. Although genetic studies have established important roles for actin and actin-binding proteins in longevity, pharmacological ap...

Remote Ischemic Conditioning in the Acute Treatment of Ischemic and Hemorrhagic Stroke: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Background Remote ischemic conditioning (RIC), a low-cost, non-invasive therapy involving brief cycles of limb ischemia and reperfusion, may be a neuroprotective adjuvant or alternative to reperfusion therapies in acute ischemic stroke (AIS) and may also have therapeutic effects...

Research on a Differential Game Considering Endurance and Marketing Effort for eVTOL Under a Subsidy Policy

Electric vertical takeoff and landing (eVTOL) represents a novel mode of transportation emerging within the low-altitude economy framework, exhibiting extensive development prospects. As a widely adopted incentive policy, government subsidy constitutes a crucial method for suppor...

Topological Quality and Fitness-for-Use Screening of a Low-Voltage Network Derived from a Utility Geographic Information System: A Real-World Distribution Utility Case Study

The availability of reliable digital models of low-voltage (LV) networks is a prerequisite for operation, planning, hosting-capacity, and asset-management studies. In practice, however, utility geodatabases often contain geometric discontinuities, implicit relationships among ass...

From Indicator to Prediction: Five Decades of Biochemical Oxygen Demand Research in Tropical Freshwaters

ABSTRACT Biochemical oxygen demand (BOD) remains a core indicator of organic pollution in freshwater monitoring, but its role in water policy and practice is changing as water‐quality assessment moves toward predictive, integrative, and decision‐support approaches. This transitio...

The Global Airways Unit: A Multidisciplinary Strategy for Early Diagnosis and Comorbidity Detection

ABSTRACT Background Chronic respiratory diseases impose a large global burden of morbidity, mortality, and cost. The concept of a global airway has become increasingly supported by epidemiologic, mechanistic, and clinical evidence. However, clinical care often remains fragmented...