Research works

Male Breast Cancer: An Analysis of Clinicopathological Features, Treatment Patterns, and Survival Outcomes over 10 Years from a Tertiary Center

Background/Objectives: Male breast cancer (MBC) is a rare malignancy accounting for less than 1% of all breast cancers, and current treatment recommendations are largely extrapolated from studies in women. We aimed to evaluate the clinicopathological characteristics, treatment pa...

Income and density spillover effects in German land prices

Purpose This paper aims to investigate the role of county-level income and population density effects in explaining spatial variation in German land prices from 2014 to 2018. Motivated by recent evidence that land values account for a growing share of housing price dynamics, our...

Preoperative CT-based 3D analysis of middle colic vein anatomy for complete mesocolic excision in right-sided colon cancer: a retrospective cohort study from a prospective clinical trial

Abstract Purpose Complete mesocolic excision requires central mesenteric dissection near the middle colic vein (MCV) confluence, where anatomic variability may increase operative risk. However, MCV multiplicity, confluence patterns, and relationships to the middle colic artery (M...

Analysis of 113 Mycotoxins and Plant Toxins in Wheat, Soy and Pea Protein Concentrates from the German Market Reveals, i.a., a High Prevalence of Alterperylenol in Wheat Gluten

Wheat, soy and pea protein isolates used for the production of plant-based meat alternatives were analyzed for 87 mycotoxins and 26 plant toxins by means of a validated QuEChERS-based LC-MS/MS multi-method. For wheat gluten, the results revealed the presence of Alternaria toxins,...

Diabetic plaque calcification: mechanisms, imaging phenotypes, and clinical implications

Diabetes is associated with a higher burden and heterogeneous phenotypes of plaque calcification, which may influence plaque stability and cardiovascular risk. This review examines diabetic plaque calcification as a dynamic process driven by hyperglycemia and other metabolic dist...

Static Axial–Flexural Behavior of RC Beam-End Plastic Hinges Under Spatial Frame Effects

Reinforced concrete (RC) beams undergo axial elongation during inelastic flexural deformation. In frame structures, this elongation is restrained by adjacent columns and slabs, inducing axial compression and beam overstrength, thereby amplifying force demands on columns and joint...

Combined effects of difenoconazole and salinity stress on growth, photosynthetic pigments, and oxidative responses in tomato (Solanum lycopersicum L.)

Environmental contamination by pesticides and salts is a growing agricultural issue, especially in arid and semi-arid regions. Difenoconazole (DIF), a commonly used fungicide, and sodium chloride (NaCl), a widespread salinity stressor, often coexist in soil and water, yet their c...

Prevalence of Acetabular Dysplasia in Early Adolescents From the General Population: A Generation R Study

Background: Acetabular dysplasia is an important risk factor for hip complaints and osteoarthritis in (young) adults. Early identification during childhood is important, as timely intervention may prevent irreversible joint damage. Although traditionally considered an infant-onse...

Expansion and Nitrate-Responsive Expression of NRT3 Transport Regulators in Maritime Pine

Nitrate uptake in plants is mediated by coordinated transporter systems, which include NPF, NRT2 and NRT3 proteins. While these families have been extensively studied in angiosperms, their evolution and regulation in conifers are still not well understood. In this work, we examin...

Comparative Effectiveness of Continuous Glucose Monitoring Versus Blood Glucose Monitoring in Pregnancy With Diabetes: Systematic Review and Meta-analysis With Trial Sequential Analysis

OBJECTIVE The value of adding continuous glucose monitoring (CGM) to blood glucose monitoring (BGM) during pregnancy is unclear. PURPOSE To clarify CGM's role in pregnancy using meta-analysis, Grading of Recommendations Assessment, Development and Evaluation (GRADE) ratings, harm...

Implementation of specialised care improves survival in patients with amyotrophic lateral sclerosis

Abstract Objective Access to multidisciplinary care influences survival in patients with amyotrophic lateral sclerosis (pwALS). However, real-world data comparing structured specialised care with general neurological management remain limited. We aimed to assess the influence of...

Explainable Deep Learning Model for Predicting Overall Survival in Patients Receiving Palliative Radiotherapy for Bone Metastases

Purpose: Although machine learning-based prediction of overall survival (OS) in palliative radiotherapy for bone metastases has been investigated, explainable deep learning (DL) models remain underexplored. This study aimed to develop and validate an explainable DL model to predi...

A bottom-up perspective on multicenter bonding in discrete molecular systems

The understanding of the properties of advanced materials requires a deep knowledge of chemical bonding beyond the classical chemical bonding picture of covalent, ionic, and metallic bonds. For this purpose, we need to include multicenter bonds into the equation. Here, we approac...

Bio-Inspired Low-Light Image Enhancement with Large Kernel Convolution and Attention

Nighttime driving safety remains a critical challenge in modern transportation systems: insufficient ambient lighting significantly degrades visual perception quality, adversely affecting both human drivers and advanced driver-assistance systems (ADAS) and directly threatening ro...

Nonadditive gene expression and reduced homoeolog expression bias in an intraspecific hexaploid wheat hybrid

Abstract Background Intraspecific hybridization in allopolyploid plants can generate additive and nonadditive changes in gene expression through interactions between divergent parental genomes. However, how it simultaneously affects gene expression and the relative expression of...

Risk of Abnormal Uterine Bleeding in Women with Chronic Spontaneous Urticaria: Korean Nationwide Population-Based Cohort

Background: Chronic spontaneous urticaria (CSU) is an immune-mediated disorder driven by mast cell activation, whereas abnormal uterine bleeding (AUB) is a heterogeneous condition with diverse etiologies. Although immune and inflammatory dysregulation has been independently impli...

Disparities in sleep-disordered breathing: epidemiology, mechanisms, and pathways toward equity– a narrative review

Purpose of review Sleep-disordered breathing (SDB), encompassing obstructive sleep apnea (OSA) and related conditions, affects tens of millions of individuals in the United States and is associated with substantial cardiovascular, metabolic, and neurocognitive morbidity. However,...

Management of Saline–Sodic Soils Using Compost and Gypsum to Improve Maize and Sorghum Production in Northeastern Ethiopia

ABSTRACT Background Soil salinity and sodicity are major constraints to crop production in the irrigated agro‐pastoral systems of northeastern Ethiopia, particularly in the Asaita district of the Afar region. Aim This study evaluated the effectiveness of integrated organic and in...

Exercise-Induced Acid–Base, Electrolyte, and Metabolic Responses in Colombian Creole Horses Across Different Gait Modalities

Exercise physiology in Colombian Creole Horses remains poorly characterized despite the breed’s extensive use in athletic activities. The objective of this study was to evaluate exercise-induced changes in blood biochemical and gas parameters and to determine whether these respon...

Seven‐Fold Compression of Mid‐Infrared Pulses Using a Series of Titanium Dioxide Plates

ABSTRACT We demonstrate a compact approach for generating 2‐cycle mid‐infrared pulses centered at 2.038 µm using bulk TiO 2 plates for nonlinear spectral broadening and self‐compression. Starting from a passively CEP‐stable idler pulse produced by an optical parametric amplifier,...