Research works

Modular Platform for Directing-Group-Free Radical Dicarbofunctionalization of Unactivated Alkenes via Dual Nickel/Energy-Transfer Catalysis

Abstract Multicomponent cross-coupling reactions of alkenes offer a powerful strategy for constructing three-dimensional, sp3 -rich molecular architectures, a key objective in modern medicinal chemistry. However, the regioselective dicarbofunctionalization of unactivated alkenes...

Short-term oxycodone exposure produces delayed and persistent gut microbiome disruption in mice

Abstract The gut microbiome is a critical part of host homeostasis, yet its resilience following opioid exposure remains poorly understood. While opioid-induced short-term dysbiosis is well documented, the long-term recovery dynamics following oxycodone remain unclear. This study...

Exploring the professional nurse advocate role in quality improvement: a qualitative study

Background: the professional nurse advocate (PNA) programme was introduced in 2021 to support nurse wellbeing and resilience after the pandemic through the Advocating for Education Quality Improvement (A-EQUIP) model. However, the impact of PNAs' quality improvement (QI) work rem...

Reproducibility, Replicability, and Research Quality in Homogeneous Catalysis

Abstract Researchers from all sectors of homogeneous catalysis convened in response to concerns regarding reproducibility in science to analyze the issue and provide recommendations. In addition to an in-person workshop, the group engaged the broader homogeneous catalysis communi...

A total-Lagrangian vectorial lattice Boltzmann method for finite-strain hyperelastic dynamics

Inspired by the vectorial lattice Boltzmann method for linear elastodynamics \citep{boolakee2025linear}, we construct a total-Lagrangian vectorial lattice Boltzmann formulation for two-dimensional finite-strain hyperelastic dynamics. The governing equations are first written as a...

Measuring Reasoning Quality in LLMs: A Multi-Dimensional Behavioral Framework

Despite remarkable progress on reasoning benchmarks, current LLM evaluation practice remains anchored to final-answer correctness. This provides limited insight into how models reason, how reliably they behave under contextual variation, or how efficiently they reach conclusions....

Streaming Molecular Dynamics Simulation Data for On-the-Fly Processing and Analysis

Abstract Only a small fraction of the data generated in state-of-the-art all-atom multimicrosecond molecular dynamics (MD) simulations is typically analyzed. With femtosecond integration steps, microsecond simulations generate billions of time steps with a complete set of atomic...

Widespread circulation of West Nile and Usutu viruses in sedentary and migratory avifauna: A two-year study (2024–2025) of active surveillance in South of France

Abstract West Nile virus (WNV) and Usutu virus (USUV) are neurotropic Orthoflaviviruses sharing a similar enzootic transmission cycle primarily involving Culex pipiens mosquitoes as vectors and birds as amplifying hosts. First identified in Africa, both viruses established endemi...

Development and comparative analysis of predictive length of stay models using machine learning in Malaysian tertiary hospitals

Abstract Hospital length of stay (LOS) is a critical indicator of healthcare efficiency and resource allocation. While predictive modelling has escalated globally, there is a notable sparsity of literature utilising large-scale, real-world data from the Malaysian public health fr...

Rate–Distortion Optimised Image Compression with Directional Intra Prediction, Adaptive Transforms and Context-Adaptive Arithmetic Coding

This paper presents a complete still-image codec built onrate–distortion (RD) optimised block coding. The design combines aquadtree partition over 16×16 to 4×4 coding units, thirty-five directionalintra prediction modes with most-probable-mode signalling, adaptiveselection betwee...

TSPO PET selectively detects the denervated skeletal muscle district remodeling after experimental peripheral nerve injury

Abstract Background Peripheral nerve injury induces inflammatory and stress-related remodeling in downstream skeletal muscle before overt atrophy develops, yet non-invasive approaches capable of detecting and anatomically localizing early muscle involvement remain limited. The 18...

Experimental investigation on the effect of thermal ageing on mechanical characteristics of polyamide12 processed using selective laser sintering

Abstract This study investigates the variation in mechanical characteristics of Polyamide-12 (PA-12) specimens on account of thermal ageing. PA-12 has high tensile strength, long life, high chemical resistance, and excellent electrical insulation elements for use in various indus...

Horizon-Like Emission from Curvature-Bound Coherence Fields

Version 2.0 is a substantive corrected revision of the original Horizon-Like Emission from Curvature-Bound Coherence Fields study. The paper investigates horizon-like emission from a deterministic, curvature-bound coherence field within the Coherence Geometry framework. A reduced...

Reproducible human reward imaging phenotypes exhibit differential sensitivity to dopamine D2 receptor antagonism

Abstract Human reward processing varies along cue-centric and outcome-centric axes, but a reproducible mechanistic account of individual variation in incentive salience attribution has been lacking. Using fMRI across five cohorts (N-total=1,251; N1=890; N2=245; N3=34; N4=48; N5=3...

The structure of infrastructure adoption: competition of hydrogen and electric for long-haul freight decarbonization

Long-haul freight decarbonization requires deploying hydrogen refueling stations (HRSs) across networks designed around incumbent diesel supply. Existing planning tools treat node-level demand as uniform, ignoring how it emerges from the coupling between freight flows and technol...

Modeling Higher Pairs in Spherical Mechanisms

The kinematics of spherical mechanisms (SMs) shares many features with that of planar mechanisms (PMs). Specifically, both types of mechanisms can be studied by projecting their geometry onto a reference surface: a plane (the motion plane) for PMs and a sphere (the reference sphe...

Pixel-Level Sentinel-2 Modeling Reveals Scale-Dependent Edge Effects and Structural Heterogeneity in Semideciduous Seasonal Forest Fragments of the Brazilian Cerrado

Forest edge effects are commonly interpreted as radial gradients from the edge toward the interior, but this assumption may oversimplify the spatial organization of heterogeneous tropical forest fragments. Here, we integrated field-based phytosociological data with Sentinel-2 spe...

Sensitivity Analysis of Perceptual Stabilization under Historical Compression

This paper examines parameter sensitivity in a toy computational realization of perceptual stabilization under historical compression. The analysis varies state coordinates, coupling coefficients, thresholds, and selector–dominance relations while preserving the declared computat...

Conjunctive dynamic searchable symmetric encryption

Abstract A practical searchable symmetric encryption (SSE) should allow users to privately store documents on untrusted servers with the abilities to (1) search with multiple keywords, and (2) add or delete documents dynamically. The oblivious cross tag () construction from Crypt...

Sequence-defined Digital Bottlebrush Polymers for Programmable Oligonucleotide Delivery

Oligonucleotide therapeutics hold transformative potential, yet their clinical translation is hindered by delivery barriers, including rapid renal/hepatic clearance and poor organ specificity. Bottlebrush polymers conjugates have emerged as a promising vector to address these lim...