Research works

The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis

Abstract Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Although essential for survival and a validated drug target, the mechanisms of heme biomineralizatio...

Esculentin-1aDerived Peptides Potentiate CeftazidimeActivity against Multidrug-Resistant KPC-Producing Klebsiella pneumoniae

Abstract Carbapenemase-producing Klebsiella pneumoniae represents a major clinical threat due to the multidrug-resistant phenotype of this Gram-negative bacterium and to the limited available therapeutic options. Currently, antimicrobial peptides are regarded as promising candida...

AlkylsuccinylatedBentonite–GelMA Hybrid Hydrogelsfor Enhanced Mechanics and Osteogenic Drug Delivery

Abstract Bentonite is an attractive inorganic material for biomedical applications owing to its biocompatibility and large surface area. Here, we report a straightforward yet effective alkylsuccinylation strategy to tailor the bentonite surface with hydrophobic functionalities. S...

Pressure-SelectiveMagnetic Switching via SpatiallySeparated Soft Interlayer and Rigid Charge-Transfer Intralayer

Abstract We report a pressure-responsive molecule-based magnet featuring a layered cyanido-bridged Co–W assembly, [{CoII(4-phenoxypyridine)4}3{WV(CN)8}2], exhibiting a distinct pressure-selective magnetic behavior. The compound forms two-dimensional charge-transfer layers with la...

Candidate Biological Indicators of Occupational Stress in Healthcare Workers: Heart Rate, Free Triiodothyronine and HDL Cholesterol—A Cross-Sectional Study

Background/Objectives: Healthcare staff, especially nurses, face high occupational stress, yet objective biological indicators that complement self-report are not well established. We examined whether metabolic, hormonal and physiological markers act as indicators of stress and r...

A Mechanism-Based Classification and Review of Endoscopic and Ultrasound-Guided Carpal Tunnel Release

Background: Minimally invasive carpal tunnel release (CTR) approaches, including endoscopic and ultrasound-guided, encompass a range of distinct techniques. These approaches have been increasingly adopted across both surgical and non-surgical specialties. However, the literature...

An ensemble machine learning framework for accurate ransomware detection and family classification using LightGBM and random forest

Abstract Ransomware is a critical cybersecurity threat that leverages advanced encryption techniques to compromise individuals, organizations, and even national infrastructure. Ransomware incidents have increased exponentially in the past 5 years, with recent studies indicating t...

From thunder to silence: Cochlear implantation for bilateral profound sensorineural hearing loss after lightning strike

INTRODUCTION: Lightning strikes can cause diverse neuro-otologic injuries. Tympanic membrane rupture is common, whereas bilateral profound sensorineural hearing loss with vestibular dysfunction and perilymphatic fistula is rare. Cochlear implantation for lightning-induced deafnes...

Bridging Nanoscopic Surface Heterogeneity and MacroscopicNucleation Rates: A Perspective on Probabilistic Approaches

Abstract Predicting the number of newly formed crystals and their spatial distribution on surfaces or within pore spaces matters across many fields, from structural biology to coupled fluid flow and reactive transport in porous media to atmospheric physics. Nucleation occurs at m...

Behavioural and cognitive determinants of financial loss and mental health deterioration following cybercrime victimisation

Abstract The rapid growth in the use of digital technologies has led to increased exposure to cybercrime, with significant financial and psychological consequences. This study examines the behavioural and cognitive factors that affect cybercrime victimisation and its outcomes. Dr...

Stage-dependent performance and molecular subtype-specific relapse patterns on same-session [18F]FDG PET/contrast-enhanced CT in breast cancer

PURPOSE: To evaluate stage-dependent performance of same-session [18F]FDG PET/contrast-enhanced CT (PET/ceCT) for initial breast cancer staging and PET/ceCT-detected relapse patterns during follow-up. METHODS: This retrospective single-centre study included a primary staging coho...

The hydrogeological and tectonic features as the crucial factors for the hydro-geochemistry of surface and groundwater in active geothermal systems: The case study of Methana Peninsula in Greece

Abstract Active geothermal systems developed in coastal volcanic environments are characterized by complex interactions among magmatic fluids, groundwater, seawater, and structurally controlled permeability. The Methana Peninsula (western Hellenic Volcanic Arc, Greece) represents...

A Comprehensive Review of Mesoporous Silica Nanoparticles in DrugFormulation: Synthesis, Characterization, and Applications

The development of efficient and targeted drug delivery systems remains a significant challenge, particularly for active pharmaceutical ingredients with poor aqueous solubility. Among various nanocarrier systems, Mesoporous Silica Nanoparticles (MSNs) have emerged as promising ca...

Fatigue Damage of AA2024 Fiber–Metal Laminates With Architected TPU Interlayers and Graphene‐Modified Interfaces

ABSTRACT This study investigates the fatigue behavior of Aluminum 2024 fiber–metal laminates incorporating three‐dimensionally printed thermoplastic polyurethane core architectures and graphene‐modified adhesive interfaces. Three core geometries, namely, diagonal, diamond, and he...

Biodeterioration Control of the Longhu Pagoda Stone Heritage, China: Identification of Deteriogens and Evaluation of Biocidal Efficacy

Longhu Pagoda, a national key cultural heritage site located at the southern foot of Hushan Mountain in Liubao, Jinan, Shandong Province, is a masterpiece of Tang-dynasty stone pagoda architecture and a core component of the Shentong Temple heritage complex alongside the Four Gat...

Fructose induces PERK-dependent ER stress and mitochondrial dysfunction via nucleotide depletion in clear cell renal cell carcinoma

Abstract Clear cell renal cell carcinoma (ccRCC) exhibits a paradoxical fructose metabolism signature characterized by upregulation of the fructose transporter GLUT5 alongside downregulation of the catabolic enzymes (ketohexokinase, aldolase B, and triokinase), a pattern associat...

Why they go: behavioral logic of rural micro-vacations in China through push–pull motivation and the theory of planned behavior

Rural micro-vacations are expanding in China, yet their behavioral mechanisms remain insufficiently specified. This study advances a framework linking motivation, cognition, and intention that integrates push–pull motivation with the Theory of Planned Behavior. Using survey data...

Black Box and Beyond: Auditing Large Language Models, AI Agents, and AI Infrastructure Under the UK and EU Regulatory Frameworks

Regulators in the European Union and the United Kingdom now require organisations to make high risk AI systems auditable, and neither has said what an audit record must be. This paper supplies the missing content. It argues first that a record is evidence only where its modificat...

Yes-associated Protein Is Involved in Tubular Epithelial Cell Apoptosis and Renal Tissue Damage in Early Sepsis-Associated Acute Kidney Injury

Abstract Sepsis-associated acute kidney injury (SA-AKI) is a distinct form of acute kidney injury in critically ill patients. It is characterized by tubular epithelial cell damage and apoptosis. The Hippo-Yes-associated protein (YAP) pathway plays dual roles in renal injury and r...

Complex linkage disequilibrium and quantitative trait loci in chicken

Abstract Linkage disequilibrium (LD) underpins mapping studies of Quantitative Trait Loci Regions (QTLRs). A common yet misled assumption assumes the closest sites to a significant marker as causative mutation candidates. We studied chicken LD of mapped chicken QTLRs for Marek’s...