Autoimmune and inflammatory diseases associated with T-cell clonal expansion
Abstract
Autoimmune and inflammatory diseases (AID) result from a breakdown of immune tolerance, often driven by T-cell dysregulation and sometimes associated with clonal T-cell expansion. While T-cell large granular lymphocyte leukemia (LGL-L) is a well-defined clonal disorder commonly associated with AID, the clinical relevance of T-cell clones of uncertain significance (T-CUS) remains unclear. We conducted a retrospective multicenter study across six French centers, including patients with persistent circulating clonal T cells associated with AID, confirmed by T-cell receptor gene rearrangement. T-cell clones ≥ 0.5 × 10⁹/L, or low-count clones (.
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Authors: Camille Frelicot, T. Lamy, Nicolas Chapuis, Alexis Régent, Emmanuel Ribeiro, Guillemette Fouquet, Bénédicte Deau, F. Rétornaz, Marinela Sisiroi, Jean-Maxime Piot, Nathalie Denizon, Cédric Pastoret, Aline Moignet, Yannick Le Bris, Nicolas Blin, Christian Lavigne, Carole Lacout, Agathe Boussaroque, Cécile Guenot, Lionel Galicier, Mickael Ebbo, N. Schleinitz, Chloé Dol, Matthieu Groh, Jérémie Dion, Benjamin Terrier, Paul Legendre
Institutions: Inserm, Centre National de la Recherche Scientifique, Assistance Publique – Hôpitaux de Paris, Hôpital Européen, Centre Hospitalier Universitaire de Nantes, Nantes Université, Université d'Angers, Université de Versailles Saint-Quentin-en-Yvelines, Université de Rennes, Hôpital Cochin, Assistance Publique Hôpitaux de Marseille, Hôpital de la Timone, Centre Hospitalier Universitaire de Rennes, Université Rennes 2, Institut des Maladies Génétiques Imagine, Centre Hospitalier Universitaire de Toulouse, Centre Hospitalier du Mans, Hôpital Saint-André