Université Rennes 2

Autoimmune and inflammatory diseases associated with T-cell clonal expansion

Autoimmune and inflammatory diseases (AID) result from a breakdown of immune tolerance, often driven by T-cell dysregulation and sometimes associated with clonal T-cell expansion. While T-cell large granular lymphocyte leukemia (LGL-L) is a well-defined clonal disorder commonly a...

Transarterial embolization in musculoskeletal care: an indication-stratified narrative review

Abstract Background Transarterial embolization (TAE) is increasingly used across a broad spectrum of musculoskeletal conditions, ranging from established hemostatic and tumor-related indications to emerging pain-directed procedures for degenerative joint disease and chronic infla...

TAIL EXPECTILE ESTIMATION IN THE SEMIPARAMETRIC GENERALIZED PARETO MODEL

Expectiles have received increasing attention as a market risk measure that is both coherent and elicitable. They are defined as a least squares analog to quantiles. Their estimation from heavy-tailed loss data in an extreme value framework is an important and difficult problem,...

Total Constitutionalism and the Interrelated Constitutionalisation of the European Court of Human Rights through Liberal NGO-driven Litigation and Advocacy

Our article studies the main features of a constitutionalism trend reflected in the influence of private interest groups over jurisdictional expansion and interpretative advances operated by the European Court of Human Rights. We posit that liberal interests’ litigation bears pot...

Metformin Spacer Conformation Is a Structure-Directing Element in a 2D Perovskite with Strong X-ray Response

Abstract Direct X-ray detection in two-dimensional (2D) hybrid metal-halide perovskites is dictated by the interplay between organic spacer chemistry, crystal structure, and charge transport. Among these materials, the metformin (MF2+)-based perovskite MFPbI4 has recently emerged...

How to manage: acute-on-chronic liver failure

Acute on chronic liver failure has emerged as a distinct clinical entity over the past few decades. While mortality remains highest for patients who develop liver and multiple non-liver organ failures, earlier recognition of the syndrome, including identification and management o...

Integration of dentists into primary care teams in underserved areas: a qualitative study

Abstract Background Integrating oral health into primary care is increasingly promoted to enhance coordinated, patient-centred care, particularly in underserved areas experiencing workforce shortages. In France, multiprofessional primary care teams organised under the Société Int...

Synthesis, Photophysical Properties, and Ab Initio Calculations of 2-(2-Hydroxy/methoxyphenyl)pyrimidines Substituted by Sterically Hindered Electron-Donating Groups

Abstract A series of 2-(2-hydroxyphenyl)pyrimidines bearing sterically hindered electron-donating groups (DMAC, PXZ, PTZ, and NPh2), together with their methoxy precursors, were synthesized and investigated by photophysical studies and ab initio calculations. While the hydroxy de...

Core open science practices in major medical journals: development of an automatized tool based on a Large Language Model

Background Open science practices are increasingly promoted to improve the transparency and reproducibility of biomedical research, and their large-scale monitoring has been identified as a priority by initiatives such as the UNESCO Recommendation on Open Science. Existing automa...

Reconstructive urologists’ approach to penile inversion vulvovaginoplasty: Multicenter outcomes and volume–outcome relationship

Introduction Gender-affirming vulvovaginoplasty is a key procedure for transfeminine individuals, yet robust multicenter data on outcomes and complications remain limited. This study evaluated perioperative outcomes, postoperative morbidity, and factors associated with complicati...

Bioprosthetic Valve Failure After Transcatheter Aortic Valve Replacement

BACKGROUND: Data on the long-term incidence and clinical impact of bioprosthetic valve failure (BVF) after transcatheter aortic valve replacement remain limited. This study aimed to assess the incidence, predictors, and clinical impact of BVF following transcatheter aortic valve...

Referent Mention When Parents Tell a Story: A Means to Explain Children's Referential Uses in Narratives

Abstract This study aims to describe parents’ referential choices while recounting a story to their child. Indeed, in choosing referring expressions (REs), until the 8 years of age or even later, children are less sensitive to discourse accessibility than factors such as visual a...

Tailoring Liquid Crystalline Self‐Assembly and Photophysical Properties of Unsymmetrical Fluorenones via Polar Terminal Groups

ABSTRACT In this work, a series of novel unsymmetrical fluorenone derivatives bearing various head groups (H, Br, NO 2 , NH 2 , and CN) was synthesized and investigated with respect to their mesomorphic and photophysical properties. Depending on the head group, SmA, N, or SmC pha...