Institution
Institut des Maladies Génétiques Imagine
Recent research
- Health & MedicineOpen access
Abstract Objective To assess the efficacy and safety of fenfluramine in patients with Dravet syndrome (DS) stratified by age, number of previously attempted antiseizure medications (ASMs), and SCN1A pathogenic variant status. Methods In this post hoc analysis, data from three ran...
- BiologyOpen access
Paediatric therapeutic development workshop on osteosarcoma
The fourth Paediatric Therapeutic Development Workshop focused on osteosarcoma, the most common primary bone cancer in children and young adults. Current treatment of osteosarcoma comprises surgery and chemotherapy. Outcome has shown very little improvement over the last four dec...
- Biology
Ciliogenic pancreatopathy reveals a link between ciliopathies and exocrine pancreatic disease
Abstract Background While pancreatic cysts have been described in syndromic ciliopathies, the pancreas is not commonly recognized as a target organ. However, several ciliary gene knockout mouse models develop a pancreatic phenotype combining acinar atrophy and adipocyte accumulat...
- Health & MedicineOpen access
Abstract Chikungunya virus (CHIKV) infection is typically not life-threatening but may, in rare cases, affect the central nervous system (CNS). In three cohorts of confirmed CHIKV cases from Martinique (French overseas territory) and Brazil (patients aged 0–89 years, n = 245), 20...
- AI & Computing
Across Human Factors Engineering, UX, CX, HCD, HSI, and related disciplines, teams frequently use different words for similar concepts, or the same words for very different work. The result: hiring confusion, mismatched expectations, unclear deliverables, and difficulty explainin...