Centre Hospitalier Universitaire de Rennes

Paraneoplastic podocytopathies with nephrotic syndrome in solid cancers with C-Maf Inducing Protein expression

Abstract Background The main features of minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) associated with solid cancer (paraneoplastic podocytopathy with nephrotic syndrome, PPNS) remain poorly described. Methods In this French retrospective study, we fo...

Intermittent or Continuous Renal-Replacement Therapy in Acute Kidney Injury

BackgroundThe preferred method of renal-replacement therapy for acute kidney injury in critically ill patients remains uncertain. MethodsIn this multicenter, open-label, noninferiority trial, we randomly assigned critically ill adults with acute kidney injury who had indications...

Guidelines for Decisions to Withhold or Withdraw Life-Sustaining Treatments (LST) in Adult ICU

OBJECTIVE: The French Society of Anaesthesia and Intensive Care Medicine (Société française d'anesthésie et de réanimation, SFAR) and the French Society of Physical Medicine and Rehabilitation (Société Française de Médecine Physique et de Réadaptation (SOFMER)) aimed at providing...

Autoimmune and inflammatory diseases associated with T-cell clonal expansion

Autoimmune and inflammatory diseases (AID) result from a breakdown of immune tolerance, often driven by T-cell dysregulation and sometimes associated with clonal T-cell expansion. While T-cell large granular lymphocyte leukemia (LGL-L) is a well-defined clonal disorder commonly a...

Transarterial embolization in musculoskeletal care: an indication-stratified narrative review

Abstract Background Transarterial embolization (TAE) is increasingly used across a broad spectrum of musculoskeletal conditions, ranging from established hemostatic and tumor-related indications to emerging pain-directed procedures for degenerative joint disease and chronic infla...

Unsupervised deep generative models for anomaly detection in neuroimaging: A systematic scoping review

Unsupervised anomaly detection (UAD) based on deep generative modelling has been increasingly investigated for identifying pathological brain abnormalities without requiring voxel-level annotations. By learning the distribution of healthy anatomy and generating pseudo-healthy rec...

Immune‐related adverse events with mogamulizumab in cutaneous T‐cell lymphoma: A multicentre study

BACKGROUND: Mogamulizumab, an anti-CCR4 monoclonal antibody used in advanced mycosis fungoides (MF) and Sezary syndrome (SS), also depletes regulatory T cells, potentially leading to immune-related adverse events (irAEs). Unlike mogamulizumab-associated rash (MAR), other irAEs re...

How to manage: acute-on-chronic liver failure

Acute on chronic liver failure has emerged as a distinct clinical entity over the past few decades. While mortality remains highest for patients who develop liver and multiple non-liver organ failures, earlier recognition of the syndrome, including identification and management o...

Neurofeedback-induced network plasticity in motor and default mode networks correlates with motor recovery after stroke

Abstract Stroke often results in long-term motor impairments, necessitating innovative rehabilitation strategies. Neurofeedback (NF) has emerged as a promising tool to promote functional recovery after stroke by enabling patients to modulate targeted brain activity. In this study...

Integration of dentists into primary care teams in underserved areas: a qualitative study

Abstract Background Integrating oral health into primary care is increasingly promoted to enhance coordinated, patient-centred care, particularly in underserved areas experiencing workforce shortages. In France, multiprofessional primary care teams organised under the Société Int...

Early Multicentre Outcomes of Endovascular Aortic Arch Repair Using a Custom-Made Triple-Branch NEXUS TRE Endograft System (TRE-ASURE Study)

Objective: To report the first multicentre European experience with the custom-made NEXUS TRE triple-branch endograft for fully endovascular, debranch-free repair of complex aortic arch pathology, focusing on technical feasibility and early safety outcomes. Methods: This retrospe...

A single-cell atlas of large B cell lymphomas reveals distinct malignant archetypes predictive of clinical outcomes

Large B cell lymphomas (LBCLs) exhibit significant heterogeneity which leads to disparate treatment response, with up to 40% of patients developing refractory disease or relapsing within the first two years. To understand the cellular and molecular basis of this heterogeneity, we...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Surgical Morbidity and Short-Term Oncologic Status after Prophylactic-Intent Thyroidectomy in a Cohort of Children with MEN2 from the Multicenter GTE ENDOCAN-RENATEN Study

BACKGROUND: Children carrying germline RET mutations associated with multiple endocrine neoplasia type 2 (MEN2) are at high risk of developing medullary thyroid carcinoma (MTC). Prophylactic-intent thyroidectomy is recommended during childhood to prevent progression to advanced d...