Nantes Université

The clinical and molecular spectrum of AGO2-associated Lessel-Kreienkamp neurodevelopmental syndrome

Abstract Background Pathogenic variants in AGO2 ,encoding a central component of the RNA-induced silencing complex (RISC), cause the neurodevelopmental disorder Lessel-Kreienkamp syndrome (LESKRES). The variant spectrum and associated molecular mechanisms underlying phenotypic va...

Use of waste marble powder as a cement substitute in three-dimensionally printable mortars

The potential of Tunisian marble waste as a sustainable partial substitute for cement in mortars for three-dimensional printing (3DP) for construction applications was explored. Marble powder (MP) generated from cutting and finishing processes was characterised through X-ray diff...

Hybrid flax/carbon bonded composite patches for strengthening of steel plates: layup and adhesive effect

Adhesive bonding of Fiber-Reinforced Polymer (FRP) patches is increasingly used to strengthen steel structures. Considering that carbon FRP (CFRP) and epoxy adhesives are the primary materials in industrial applications, this study explores the feasibility of hybridizing CFRPs wi...

Breast cancer metabolism and responsiveness to dichloroacetate: relationships with 15N and 13C natural abundance

Abstract Background Metabolic reprogramming is a hallmark of breast cancer (BrCa), with alterations in glycolysis, glutamine metabolism, and the urea cycle contributing to tumour progression. Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor, shifts metabolis...

Evaluation of a Cerebrospinal Fluid and Blood-Perfused Cadaveric Model in Neurosurgical Simulation Training

BACKGROUND AND OBJECTIVES: In skull base neurosurgery, the pterional approach is of particular importance for many indications. These approaches are challenging for young inexperienced neurosurgeon. That is why training on realistic model is a true added value. We aimed to develo...

Up‐regulation of the kinase LRRK2, in enteric glia contributes to mucosal barrier impairment in Parkinson's disease via secretory autophagy

Background and Purpose Patients with Parkinson's disease (PD) show intestinal epithelial barrier (IEB) alterations, enteric gliosis and inflammation that could contribute to gastrointestinal symptoms. Moreover, changes in leucine rich‐repeat kinase 2 (LRRK2) expression/activity h...

Long‐Term Outcomes of Continent Cutaneous Urinary Diversion in Patients With Neurogenic Lower Urinary Tract Dysfunction: A Monocentric Experience

PURPOSE: To evaluate long-term outcomes and quality of life after continent cutaneous urinary diversion (CCUD) in patients with neurogenic lower urinary tract dysfunction (NLUTD). MATERIALS AND METHODS: We conducted a retrospective, single-center study including all patients with...

Enhancing Electrochemiluminescence with Two-ComponentSpontaneously Adsorbed Monolayers and Films

Abstract Multicomponent films offer important opportunities in electrochemiluminescence, ECL, including the possibility to coimmobilize an electron transfer mediator to facilitate the generation of radicals from a coreactant and to enhance indirect ECL at potentials that are lowe...

The top 10 priorities in palliative care research in France: final results of the AXEPRO study

Prioritizing research is essential to reduce waste, particularly in palliative care, a field with historically limited investment. To identify and rank the top 10 unanswered palliative care research questions in France according to patients, caregivers, healthcare professionals a...

CRISPR screens reveal MCT1-driven metabolic escape from SMAD3 inhibition as a therapeutic vulnerability

Resistance to therapy remains a critical challenge in cancer. This is exemplified by TGF-β pathway inhibitors which, despite broad clinical testing, have failed to deliver survival benefit. More precise SMAD3 targeting has shown preclinical promise, yet resistance mechanisms to S...

Impaired gastrocnemius medialis muscle-tendon decoupling reduces gait efficiency in spastic paresis syndrome

Introduction Muscle-tendon unit interactions are crucial for efficient walking but remain unstudied in adult-onset spastic paresis. This cross-sectional study evaluated the relative contributions of the Achilles tendon, muscle fascicles, and muscle belly to the dynamics of the ga...

33rd GP2A Annual Medicinal Chemistry Conference, XIVth Paul Ehrlich MedChem Euro-PhD Network Meeting & COST Action One Health Drugs Against Parasitic Vector Borne Diseases in Europe and Beyond (OneHealthdrugs)

The 33rd Annual Conference of the Group for the Promotion of Pharmaceutical Chemistry in Academia (GP2A), held in Nantes from 11 to 13 June 2025, marked a significant expansion of the organization’s scope and collaborative efforts. Building on the success of the previous meeting...

Nonfermenting Gram-Negative Bacilli Other Than Pseudomonas and Acinetobacter Species in Pediatric Blood Cultures: A Multicenter European Analysis

BACKGROUND: Nonfermenting Gram-negative bacilli other than Pseudomonas and Acinetobacter species are increasingly recognized as opportunistic pathogens in pediatric populations, yet their epidemiology and antimicrobial resistance remain poorly defined. METHODS: We conducted a mul...

Non-invasive multiparametric characterization of essential thrombocythemia, premyelofibrosis, and overt myelofibrosis

Among myeloproliferative neoplasms (MPN), prefibrotic myelofibrosis (preMF) was defined as a distinct entity from essential thrombocythemia (ET) and primary overt myelofibrosis (PMF) since the 2016 revision of the World Health Organization (WHO) classification, while precise char...