Accurately modeling RNase H-mediated antisense oligonucleotide efficacy.
Abstract
, achieving a 5.72-fold reduction in screening effort compared to random selection. ASO Atlas provides the first systematic resource to rigorously evaluate hypotheses regarding key parameters in ASO design, including sequence composition, chemical modifications, and target region selection. Both ASO Atlas and OligoAI have been made freely accessible through an online web-tool with the aim of facilitating the accelerated optimization of ASO design.
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Authors: Barney Hill, Maisie R. Jaques, R. Nair, Nicola Whiffin, Matthew J A Wood, Stephan Sanders, Peter L. Oliver, Alyssa C. Hill, Carlo Rinaldi
Institutions: University of Oxford, University of California, San Francisco, Broad Institute, New York Genome Center, Broad Center, Centre for Human Genetics, Science Oxford, Research Complex at Harwell, Regenerative Medicine Institute