New York Genome Center

Private information leakage from polygenic risk scores

Abstract Polygenic Risk Scores (PRSs) estimate the likelihood of individuals to develop complex diseases based on their genetic variations. While their use in clinical practice and direct-to-consumer genetic testing is growing, the privacy implications of publicly sharing PRS val...

A compendium of next-generation patient-derived models for diverse cancers

Abstract The development of new therapeutics and the validation of pathogenetic cancer mechanisms require representative laboratory models 1,2 . However, existing collections represent only a fraction of the diversity observed in human cancer 2–4 . Recent technologies have enable...