Research Complex at Harwell

Weak Anion Hydration Drives LCST Behavior in Ionic Liquid–Water Mixtures: Insights from Calorimetry and Neutron Diffraction

Abstract Isothermal titration calorimetry (ITC) combined with neutron diffraction and isotopic substitution (NDIS) has been used to elucidate the molecular origins of lower critical solution temperature (LCST) behavior in the tetrabutylphosphonium 5-phenyltetrazolate/water ([P444...

Negatively Charged Polysaccharide Stabilizes Amorphous Strontium Sulfate Precursor Phase

Abstract Biomineralization describes how living organisms orchestrate the synthesis of functional inorganic materials for structural protection or mechanical support. Mineralization under biological regulation often involves amorphous mineral phases, such as amorphous calcium car...

Single-Domain Orbital Angular Momentum Mapping: Advancing Photoemission Dichroism to the Nanoscale

Abstract Circular dichroism in angle-resolved photoemission spectroscopy (CD-ARPES) is widely used to probe orbital angular momentum (OAM) and Berry-curvature-related phenomena in two-dimensional quantum materials. However, in many materials, conventional micron-scale measurement...

Construction and characterisation of the DarkSide-20k veto silicon photo-multiplier tiles

Abstract Silicon photo-multipliers (SiPMs) are state-of-the-art sensors capable of detecting a single photoelectron under cryogenic conditions, with potentially lower radioactivity than widely used photomultiplier tubes. The DarkSide-20k experiment, designed to perform direct dar...

Correlative high-speed synchrotron X-ray and inline coherent imaging of high-power laser welding

Abstract High-power laser welding is central to electric vehicle (EV) manufacturing, yet keyhole instability and associated defects remain difficult to control due to highly transient process dynamics. Here, we combine inline coherent imaging (ICI) and high-speed synchrotron X-ra...

Accurately modeling RNase H-mediated antisense oligonucleotide efficacy.

, achieving a 5.72-fold reduction in screening effort compared to random selection. ASO Atlas provides the first systematic resource to rigorously evaluate hypotheses regarding key parameters in ASO design, including sequence composition, chemical modifications, and target region...

A Self‐Supervised Framework for Space Object Behaviour Characterisation

ABSTRACT Foundation Models, which leverage large neural networks pre‐trained on unlabelled data before fine‐tuning for specific tasks, are increasingly being applied to specialised domains. Recent examples include ClimaX for climate and Clay for satellite Earth observation, but a...

A ComplexSpin-Transition Thermal Hysteresis Unlockedby Two Competing Symmetry-Breakings

Abstract The spin-crossover material [Fe(NH2trz)3](NO3)2 belongs to the class of 1D triazole-based polymeric SCO complexes. It exhibits a thermal phase transition, with a 28 K wide thermal hysteresis, characterized by phase transition temperatures T↑ = 346 K upon warming and T↓ =...

Temporal- and Spatial-Resolved Characterization of Zeolite-Based Catalysts

Abstract Zeolites and metal-zeolite catalysts are the cornerstones of heterogeneous catalysis, where performance is governed by the structural dynamics and spatial distribution of active sites. However, conventional characterization often lacks the spatiotemporal resolution neede...