Regenerative Medicine Institute

Polymer Coating Adhesion Drives Functional and Biological Outcomes in Meniscus Implants

Achieving stable integration of drug-releasing polymer coatings with load-bearing meniscus implants remains a challenge in biomaterials engineering. In this study, four surface modification strategies, femtosecond-pulsed laser treatment, oxygen plasma, polydopamine, and an ethyl-...

Long-term reprogramming of classical monocytes with altered ontogeny mediates enhanced lung injury in sepsis survivors

Patients who survive sepsis are predisposed to new hospitalizations for respiratory failure, but the underlying mechanisms are unknown. Using a murine model in which prior sepsis predisposes to enhanced lung injury, we previously discovered that classical monocytes persist in the...

Integration of dentists into primary care teams in underserved areas: a qualitative study

Abstract Background Integrating oral health into primary care is increasingly promoted to enhance coordinated, patient-centred care, particularly in underserved areas experiencing workforce shortages. In France, multiprofessional primary care teams organised under the Société Int...

The NPIS model: a consensus-based framework for evaluating non-pharmacological interventions

The term non-pharmacological intervention (NPI) refers to health prevention and care protocols supervised by healthcare professionals. However, no precise and widely adopted definition currently exists. Additionally, unlike drugs, NPIs do not have a global evaluation framework be...

Accurately modeling RNase H-mediated antisense oligonucleotide efficacy.

, achieving a 5.72-fold reduction in screening effort compared to random selection. ASO Atlas provides the first systematic resource to rigorously evaluate hypotheses regarding key parameters in ASO design, including sequence composition, chemical modifications, and target region...

Advances in regenerative medicine and their impact on cancer therapy and tumor microenvironment modulation

Regenerative medicine has emerged as a transformative field that can augment cancer therapy by leveraging stem cells, gene therapy, and tissue engineering to address limitations of conventional treatments. This review synthesizes recent advances in cell-based therapies, biomateri...

All-trans retinoic acid suppresses CD8+ T-cell terminal exhaustion and potentiates anti-PD-1 therapy in glioblastoma

Terminal exhaustion of CD8⁺ T cells limits the efficacy of immune checkpoint blockade (ICB), particularly in glioblastoma, which is characterized by an immunosuppressive tumor microenvironment. Therefore, a better understanding of the regulators of terminal exhaustion could overc...

Development and Clinical Application of a Thermally Reconstructed Platelet-Rich Plasma Concentrate-Based Biofiller (ExoFiller)

Abstract Autologous plasma-based fillers have gained interest in regenerative aesthetics as biologically active alternatives to conventional dermal fillers. However, conventional PRP-Gel formulations may be limited by rapid degradation, variable bioactivity, and insufficient stru...

Pre-Governance in Production: A Single-Operator Case Study of Constraint-First Governance at the Deployment Decision Surface

v1.1 (2026-08-22) withdraws this study's expiry findings. The status recorded as EXPIRED in the governance trace denotes a consumed approval, not an unadjudicated timeout: it is written when an escalation is approved, to spend a one-time approval. The timeout path writes a differ...

Cysteine preconditioning improves post-freeze-thaw proliferative capacity of human synovial mesenchymal stem cells

<title>Abstract</title> Background Synovial mesenchymal stem cells (MSCs) are promising for cartilage regeneration; however, freeze–thaw injury during cryopreservation impairs their proliferative capacity and may limit therapeutic efficacy. Glutathione, a key intracellular antiox...