Biochemistry, Genetics and Molecular Biology · Genetics
Researchers created a high-resolution map of genetic regulation in the human prefrontal cortex using 5.6 million nuclei from 1,384 donors. The atlas revealed cell-specific regulation of genes linked to brain disorders that bulk-tissue studies had not detected.
A study combining data from 46 cohorts found 1,260 genetic variants associated with the Big Five personality traits, including 824 not previously reported. The associations were broadly consistent across genetic ancestry groups and were linked in further analyses to behaviours and life outcomes, although they were not identical across settings or measures.
A 13-year study of 696 dementia-free adults found several distinct patterns of cognitive aging. Better cognitive trajectories were associated with faster walking, higher quality of life, more sports and mentally stimulating activities, and greater intake of plant-based foods.
