Zhejiang University

Targeting the CD4+ effector memory T cells re-expressing CD45RA suppressor galectin-7: a multi-omics-guided therapeutic strategy for idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive interstitial lung disease with limited therapeutic options. Although single-cell and spatial transcriptomics have revealed cellular heterogeneity within the IPF lung microenvironment, the immune drivers with causal rel...

Comparative CEA-Specific Near-Infrared Probes Incorporated with Confocal Laser Endomicroscopy for In Situ Imaging of Colorectal Cancer Cells

Abstract Optimizing the targeting ligand is a critical strategy to enhance the diagnostic specificity of near-infrared (NIR) confocal laser endomicroscopy (CLE) for colorectal cancer. However, it remains unclear how distinct recognition elements, specifically antibodies versus ap...

Cross-cultural adaptation, translation, and psychometric evaluation of the simplified Chinese version of the Team Emergency Assessment Measure (TEAM)

The Team Emergency Assessment Measure (TEAM) questionnaire is a validated tool for evaluating non-technical skills in emergency team performance, such as trauma or resuscitation teams. Despite its translation into multiple languages, a Simplified Chinese version has not been vali...

Causality-integrated graph learning for multi-endpoint toxicity prediction

Toxicity prediction remains a longstanding challenge in the safety assessment of numerous artificial chemicals. While conventional single-endpoint models are effective for predicting many molecular properties, they fail to capture the complex mechanisms underlying toxicity, which...

Coupled fate and cascading risks of PFAS and heavy metals/metalloids along the soil-plant-human continuum: A critical review

Per- and polyfluoroalkyl substances (PFAS) and heavy metals/metalloids frequently co-occur in soils at industrial, e-waste and fire-training sites and in biosolid- or wastewater-affected agricultural systems. Yet their coupled fate and cascading risks along the soil–plant–human c...

Harnessing Differential Restriction of Molecular Motion within a Single Fluorophore for Versatile Bioimaging

Abstract Numerous studies have highlighted how differently restricted molecular motions within molecular packing can profoundly alter the photophysical properties of fluorophores. However, most investigations remain confined to solid-state luminescence polymorphism, while extendi...

Chemo- and Stereoselective Semireduction of Alkynes to E -Alkenes Catalyzed by Nonheme Iron Enzymes

Abstract The semireduction of alkynes represents a powerful yet challenging transformation that requires simultaneous control of stereoselectivity and chemoselectivity. Currently, synthetic methods for the trans-reduction of alkynes to E-alkenes remain limited, particularly in th...

Scalable and Interpretable Chemical Neurotoxicity Prediction via Multi-Modal Gated Fusion and ChemBERTa

Abstract Chemical exposure causes adverse neurological outcomes, highlighting the need for high-throughput screening of chemical neurotoxicity. However, existing computational methods rely on single-modality inputs and lack complementary molecular information to sufficiently enha...

Orthotropic plate buckling method for the design of stainless steel structures manufactured by wire-arc directed energy deposition

Wire-arc directed energy deposition (DED-Arc) offers significant advantages for manufacturing stainless steel plates, but the inherent material anisotropy of DED-Arc stainless steel challenges the isotropic assumptions underlying current design standards (e.g., AISC 360, EN 1993-...

Electroacupuncture reverses task-dependent long-term memory deficits in rats with chronic neuropathic pain

Abstract Background Chronic pain is frequently accompanied by cognitive dysfunction, while according to the limited cognitive resource hypothesis, persistent pain may consume finite neural processing capacity, thereby impairing cognitive performance, particularly under high cogni...

Uncertainty-decomposed robust design optimization via calibrated causal inference for multi-bolt assembly process in gantry machine tools

Large-scale gantry machine tools are highly sensitive to uncertainties arising from preload variation, contact conditions, and assembly errors. These uncertainties complicate assembly parameter design and reduce the reliability of deterministic optimization methods. Existing stud...

Fusarium asiaticum FaSdhC2 Point Mutation A83V Confers Resistance to Pydiflumetofen and Development of a Rapid LAMP Detection Method

Abstract Fusarium head blight (FHB) caused by Fusarium graminearum species complex (FGSC) is a devastating disease worldwide. The new succinate dehydrogenase inhibitor pydiflumetofen is highly effective against FHB, but its growing use raises resistance concerns. In this study, w...

Noncatalytic Synthesis of High‐Density and Small‐Diameter WS 2 Nanotubes

ABSTRACT A substrate‐engineered, noncatalytic strategy is developed for the controlled synthesis of high‐density WS 2 nanotubes by decoupling nanowire precursor growth from vapor‐phase sulfuration. The process enables precise structural control and yields dense nanotube networks...

Aerobic Dehydrogenation by Coupled Electrochemical Reactions Governs Room-Temperature Proton Defect Chemistry in Functional Oxides

Abstract Tuning functional oxides by controlling ionic point defects is a well-established paradigm for designing tailored functionalities. At elevated temperatures, this is usually achieved by tuning ambient oxygen partial pressure (pO2) to regulate oxygen chemical potential and...

A collaborative perception framework for green jujube: from lightweight key point detection to posture-aware harvest analysis

Abstract Automated harvesting is pivotal to smart agriculture, yet precisely localizing picking points in complex orchard environments remains a key challenge for robotic harvesting systems. To this end, this study proposes a collaborative perception framework integrating a light...

Quantifying the Minimal Stable Footprint of Nanophotonic Inverse Design via Geometric Phase Sensitivity

ABSTRACT Adjoint‐based inverse design enables high‐performance nanophotonic devices but typically operates as a black box regarding design footprint, often resulting in spatially redundant or computationally expensive solutions. Here, we introduce a phase‐analytic framework that...

Biochar–Straw Interaction Drives Soil Carbon Accrual by Modulating Microbial Metabolic Pathways

Abstract Straw and biochar additions can enhance long-term carbon storage, yet how their interactions regulate carbon mineralization and allocation remains unclear. We conducted a 360-day microcosm incubation employing a reciprocal 13C-labeling design that paired 13C-labeled stra...

An analysis of spatial mismatch and coordination mechanisms in river-sea systems

China's port system within the Yangtze River Economic Belt has evolved from a traditional coastal port–hinterland structure into a more interactive coastal–inland port network. Coastal ports such as Shanghai port now operate as interconnected nodes, where coordination and investm...

An identification and classification framework for bridge cracks using transposed convolution-CBAM-Segformer with transfer learning

Bridge cracks seriously affect structural bearing capacity, durability and traffic safety, making accurate and efficient crack detection essential for bridge maintenance. To address the problems of feature degradation and upsampling information loss in existing segmentation model...

Sub-Poissonian Electroluminescence from Resonant Inelastic Tunneling in One-Dimensional Gold Atomic Chains

Abstract Electrically driven single-photon sources are central to integrated quantum photonics, but Poissonian carrier injection usually transfers electrical shot noise into classical photon statistics. Here we propose to suppress this bottleneck at its origin by using a one-dime...