Zhejiang University

An Adaptive In SituBiointerfacial Armoring Platformfor Long-Term Gut Microbiota Modulation

Abstract Despite the immense potential against diverse chronic inflammatory and metabolic disorders, the clinical translation of microbial therapies is largely thwarted by the delivery challenges of live biotherapeutics. Probiotics often succumb to harsh gastrointestinal conditio...

Security in the Fine‐Tuning Lifecycle of Large Language Models: Threats, Defenses, Evaluation, and Future Directions

ABSTRACT Background Fine‐tuning has become a core mechanism for adapting pretrained Large Language Models (LLMs) to downstream tasks. However, the dependence of fine‐tuning on training data, parameter update mechanisms, and reusable components provides entry points for attackers....

Translational control by RPL22L1-specific ribosomes enhances DNA repair and chemoresistance

Ribosome heterogeneity has emerged as a regulatory layer in gene expression, yet its biological roles in cancers remain poorly characterized. Here, we identify RPL22L1, a paralog of the ribosomal protein RPL22, as a key modulator of DNA damage response (DDR) in colorectal cancer...

Machine Learning-Guided Stress Atlases Reveal Co-Expression Rewiring and Divergent Cellular Deployment of Abiotic Stress Programs in Rice and Wheat

Abiotic stress limits cereal productivity, yet whether conserved stress-responsive genes retain similar transcriptional network organization and cellular deployment across cereal species remains unknown. Here, we developed a machine learning-guided comparative framework to integr...

Drainage Performance Degradation of Stone Columns Caused by Fine-Particle Migration during Shaking in Centrifuge Model Test

Abstract Stone columns are widely used in mitigating liquefaction hazards by accelerating the dissipation of excess pore pressure. However, studies on shaking-induced fine-particle migration and clogging in stone columns remain scarce. In this study, a dynamic centrifuge model te...

ACE2-PNA conjugates exploit viral endocytosis for targeted intracellular delivery and exhibit dual antiviral efficacy against SARS-CoV-2

The COVID-19 pandemic and its protracted consequences underscore the urgent need for more effective antiviral strategies. Current antiviral strategies face a persistent challenge achieving sufficient viral suppression while minimizing off-target toxicity, particularly against suc...

Microbiota Dynamics and Listeria monocytogenes Inhibition in Vacuum-Packed Brown Bear Meat Treated with β-Cyclodextrin-Encapsulated Essential Oil

Abstract This study evaluated the microbiological quality and microbiota dynamics of brown bear ( Ursus arctos ) meat treated with β-cyclodextrin inclusion complexes of Origanum vulgare essential oil (OVEO/β-CD) and Illicium verum essential oil (IVEO/β-CD) during 21 days of refri...

Organizing Large GTPase Atlastin‐Mediated Membrane Fusion by Programmable DNA Origami Platforms

ABSTRACT In eukaryotic cells, the endoplasmic reticulum (ER) utilizes membrane fusion to form interconnected networks. GTP hydrolysis‐triggered conformational changes in ER‐anchored atlastins (ATLs) have been shown to be responsible for this process, which is facilitated by the a...

Performance Optimization of Novel Laser Hybrid Ultrasonic Vibration Assisted Micro Milling for Inconel 718

Miniaturization drives advanced manufacturing essential for next-generation systems using superalloys in aerospace, biomedical and microelectronics. Hybrid machining combines distinct processes to harness their individual strengths and overcome limitations. This experimental rese...

Vision-Based Counting of Horticultural Seeds Using ViT-UNet Density Regression for Post-Harvest Quality Assessment

Reliable counting of horticultural seeds is important for seed grading, batch consistency assessment, packaging, sowing-rate control, and post-harvest quality evaluation. Manual counting is labor-intensive, whereas conventional image-processing methods can be sensitive to seed ad...

Defect‐Rich Ir Single‐Atom/NiMnO x Catalyst: From Surface Reconstruction to Practical PEM Electrolysis

ABSTRACT Developing highly active and durable catalysts for the acidic oxygen evolution reaction (OER) remains a key challenge for proton exchange membrane water electrolysis (PEMWE). Herein, we report an efficient OER catalyst constructed via a low‐temperature calcination‐hydrot...

Renovation dimensions and residents’ subjective well-being in old residential neighbourhoods: a structural equation modeling study in Hangzhou, China

Abstract Aligned with the global agenda for sustainable urban regeneration, this study examines how different dimensions of old residential community renovation relate to residents’ subjective well-being (SWB) in urban China. SWB is defined as residents’ situated evaluation of co...

Metal‐Half‐Salen Chemistry for One‐Pot Mineralization on Hydrophobic Polymer Membranes

ABSTRACT Organic–inorganic composite membranes combine the advantages of polymers and inorganic materials, yet their fabrication remains challenging due to poor interfacial compatibility, especially on chemically inert hydrophobic substrates. Here, we report a one‐pot strategy to...

Sexual dimorphism in root exudation mediates belowground neighbor recognition and shapes rhizosphere soil microbial assembly

Summary Sexual dimorphism in physiological traits is a hallmark of dioecious plants, yet whether these differences extend belowground to mediate neighbor recognition and rhizosphere microbiome assembly remains largely unexplored. Using split‐root experiments, 13 C‐pulse labeling,...

The proletarianized professoriate: Digital narcissism and affective exhaustion on academic social networks

Contemporary academic life is increasingly mediated by digital platforms that promise visibility, connection, and faster circulation of research. This article argues that the affective exhaustion associated with these conditions should not be treated only as a problem of individu...

Integrated 1D‐LC‐HRMS and Heart‐Cutting 2D‐LC–MS for Impurity Profiling and Chiral Separation of Mitiglinide Drug Substance

ABSTRACT Rationale The comprehensive quality control of chiral pharmaceuticals like mitiglinide necessitates simultaneous assessment of chemical impurities and enantiomeric purity, yet conventional workflows address these separately, leading to inefficiency. This study develops a...

Genetic screening identifies WNT5A/RYK as a determinant of extracellular vesicle fate

Extracellular vesicles (EVs) are natural mediators of intercellular communication through the transfer of cytoplasmic material from donor to recipient cells. The molecular mechanisms governing EV uptake and cargo delivery in recipient cells remain largely elusive. To address this...

Unified Friction Factor Model for Dune Beds from High to Low Submergence

Abstract Accurate prediction of flow resistance in dune-bed streams is critical for river engineering and flood management. Traditional methods, which rely on empirically partitioning total shear stress into skin and form drag, often fail under low-submergence conditions where th...

Bioactive composition and pharmacology of red wine, beer, and Huangjiu (Chinese rice wine): a review

Red wine, beer, and Huangjiu (Chinese rice wine) are widely consumed fermented alcoholic beverages whose compositions and health effects have attracted considerable interest. Current evidence indicates that fermentation endows these beverages with diverse bioactive compounds such...

All-Optically Controlled Memristive Reservoir Computing Capable of Bipolar and Parallel Coding

Physical reservoir computing (RC) utilizes intrinsic dynamics of physical systems for efficient data processing. Emerging optoelectronic RC platforms merge the benefits of electronic and photonic computation. However, conventional designs are constrained by the unipolar photoresp...