Zhejiang University

OsDRP1C mediates root development by modulating OsPIN1 cycling in rice

Summary Root length plays a crucial role in plants' ability to absorb water and nutrients from the soil. However, the molecular mechanisms underlying root elongation in rice ( Oryza sativa ) remain unclear. Here, we identified a short root mutant, short root‐31 ( sr31 ), and clon...

Next-Generation Pharmacotherapy for Uterine Leiomyomas: Combining Metformin and Ulipristal Acetate as Neoadjuvant and Adjuvant Interventions to Minimally Invasive Procedures

Uterine fibroids (leiomyomas) are the most common benign tumors of the myometrium in women of reproductive age. They are a major cause of heavy menstrual bleeding, pelvic pressure and pain, and reduced fertility in women of reproductive age. This scoping review aims to examine th...

Gastrointestinal-Responsive Jelly Fig–Alginate Microgels for Restoring Intestinal Barrier Homeostasis through Microbiota–Metabolite Remodeling

Abstract Oral biomaterials capable of protecting natural bioactives during gastrointestinal transit while restoring intestinal barrier function offer a promising strategy for inflammatory bowel disease intervention. Here, we developed edible Jelly Fig (Ficus awkeotsang Makino, JF...

From quantitative features to imaging signs: agentic AI-driven autonomous discovery in glioblastoma

Abstract The development of semantic imaging signs is time-consuming and relies heavily on clinicians’ experiential knowledge, whereas the abundance of quantitative radiomic features often poses challenges in interpretability and clinical translation. We developed an agentic AI p...

From automatic detection to segmentation: A label-efficient SAM pipeline with feature-guided star-shape priors for breast ultrasound

Accurate segmentation of breast lesions in ultrasound images is important for quantitative lesion assessment, but remains difficult because of low contrast, noise, and artifacts. The Segment Anything Model (SAM) provides a flexible prompt-based segmentation framework, yet its per...

Macrophage pyroptosis drives luminal senescence and club-cell reprogramming in 5α-reductase inhibitor-treated prostatic hyperplasia

Abstract Benign prostatic hyperplasia (BPH) is a common age-associated disease whose prevalence rises sharply with advancing age. Therapeutic responses to 5α-reductase inhibitors (5-ARIs) in BPH are heterogeneous and may ultimately culminate in the need for surgery; however, the...

ZC3H14 phosphorylation is required for nuclear speckle assembly during zygotic splicing activation in mice

Abstract Following zygotic genome activation (ZGA) in embryos, nuclear speckles, which are subnuclear domains where pre-mRNA undergoes splicing, are reassembled in a process called zygotic splicing activation (ZSA). ZSA is vital for early development, but its regulation is poorly...

Periodontitis GWAS Reveal Immune‐Biased Heritability Without Gingival Cell‐Type Resolution

Three methodologically distinct analyses partition periodontitis common-variant heritability across 27 gingival cell types. They agree on an immune-over-stromal direction but nominate three different top cell types, and a low-power analysis inverts the fibroblast signal; the curr...

Subtype-specific distribution of genetic disorders in congenital heart disease: a registry based study from China

Abstract Background Congenital heart disease (CHD) is the leading cause of birth defects. This study aimed to characterize the spectrum of genetic disorders associated with CHD. Methods CHD cases obtained from a provincial birth defect surveillance system in China between 2022 an...

Chamber-Design-Associated I n Situ Formation of HepG2 Spheroids in a Perfusable Organ-on-a-Chip

Abstract Perfused spheroid platforms enable continuous mass transport, but the role of chamber architecture in in situ spheroid assembly remains insufficiently understood. Here, we developed a perfusable organ-on-a-chip platform for the in situ formation and culture of HepG2 sphe...

BBR-RHE Co-Loaded Nanoemulsion Potentiates Anti-PD-L1 Efficacy via Lipid Metabolic Reprogramming in Triple-Negative Breast Cancer

Abstract Triple-negative breast cancer (TNBC) therapy is limited by the poor efficacy of anti-programmed death-ligand 1 (aPD-L1) monotherapy, with dysregulated lipid metabolism in the tumor microenvironment (TME) driving immunosuppression. Herein, a nanoemulsion co-loaded with be...

Defect-engineered lithium-coated BaTiO3 to enable high oxide-ion conduction in LT-SOFC

Solid oxide fuel cells (SOFCs) are emerging as transformative electrochemical energy conversion technologies owing to their superior efficiency, fuel versatility, and minimal environmental impact. Enhancing SOFCs for efficient performance at low temperatures (LT, 420–520 °C) requ...

Machine Learning Empowers Enzyme Discovery, Structure Prediction, Engineering, and Design

Abstract Enzymes are efficient and selective biocatalysts, yet obtaining enzymes with desired properties remains challenging due to vast sequence spaces, incomplete functional annotation, limited structural information, and costly experimental screening. Machine learning (ML) off...

Neonatal overfeeding accelerates age-related sarcopenia and metabolic disorders through lifelong gut mucosa and microbiota programming in mice

Early-life nutrition shapes lifelong health, yet the long-term consequences of childhood overnutrition, particularly on musculoskeletal aging, remain unclear. Here, we show that neonatal overfeeding acts as a developmental insult that accelerates age-related sarcopenia in both se...

A DMD-enabled multimode fiber wavefront shaping interface for spatially addressable optogenetic stimulation

Spatially confined and rapidly addressable light delivery is important for optogenetic stimulation when optical access to the target plane is limited. Digital micromirror device (DMD) has shown its potential for rapid optical control and wavefront shaping through scattering media...

A Study on the Identification of Partial Discharges in Typical Defects of Cross-Linked Polyethylene Cables Using the CNN-SE-RAP Algorithm

To address the reliance on manual interpretation and the limited discrimination capability of conventional methods for highly similar phase-resolved partial discharge (PRPD) patterns in cross-linked polyethylene (XLPE) cables, a convolutional neural network incorporating squeeze-...

A systems-level dissection of aging and longevity mechanisms powered by an evidence-routed AI knowledge graph

Abstract Aging is a complex biological process influenced by numerous molecular and cellular factors. A systems-level understanding of these mechanisms is essential for identifying key regulatory processes and prioritizing effective interventions. Here, we present a comprehensive...

Students and schools have distinct configurations of socio-emotional skills: a multilevel latent profile analysis

Abstract Socio-emotional skills have attracted increasing attention due to their significance to students’ academic and well-being outcomes. However, there is ongoing debate in the literature over whether students’ socio-emotional skills vary quantitatively or qualitatively. Furt...

Causality-integrated graph learning for multi-endpoint toxicity prediction

Toxicity prediction remains a longstanding challenge in the safety assessment of numerous artificial chemicals. While conventional single-endpoint models are effective for predicting many molecular properties, they fail to capture the complex mechanisms underlying toxicity, which...

Cross-cultural adaptation, translation, and psychometric evaluation of the simplified Chinese version of the Team Emergency Assessment Measure (TEAM)

The Team Emergency Assessment Measure (TEAM) questionnaire is a validated tool for evaluating non-technical skills in emergency team performance, such as trauma or resuscitation teams. Despite its translation into multiple languages, a Simplified Chinese version has not been vali...