Zhejiang University

Combined Residues of Frequently Detected Herbicides are Stronger Predictors of Soil Resistome and Virulence Potential than Single Residues

Abstract Overuse of herbicides has resulted in a global epidemic of evolved resistance in soil ecosystems. While single herbicide risk has been documented, the impact of multiple herbicide residues on the soil resistomes remains poorly understood. Our study quantified the residue...

Thermo-mechanical analysis and structural modification of the boss–liner interface in Type IV hydrogen pressure vessels

Type IV hydrogen pressure vessels rely critically on the boss–liner interface for sealing, which is challenged by coupled temperature and pressure variations. Since the localized evolution of interfacial contact behavior lacks sufficient quantitative characterization, this study...

Probabilistic Assessment of Carbon Storage Response to Reduction Planning for Sustainable Development in Shanghai: A Coupled Bidirectional CA and MC-InVEST Approach

China’s megacities are increasingly adopting land reduction planning, yet most land cover simulations remain expansion-oriented and InVEST assessments often overlook carbon density uncertainty. To address these limitations, this study developed an integrated framework coupling a...

Simulation and performance analysis of the charging/discharging processes of a condensation thermal accumulator for solar- assisted heat pump system

Driven by China's carbon peaking and carbon neutrality goals and the growing demand for clean heating, solar-assisted heat pump systems have attracted increasing attention because of their ability to integrate solar energy, ambient air heat, and phase-change thermal energy storag...

Extracellular matrix–targeted TNC-scFv armoring enhances CAR T cell persistence and antitumor activity in solid tumors

Chimeric antigen receptor T cell (CAR T cell) therapy has shown limited efficacy in solid tumors, largely due to physical and immunosuppressive barriers imposed by the tumor microenvironment (TME). Tenascin-C (TNC), an extracellular matrix protein highly expressed in multiple sol...

Enhancing CO2-to-methanol conversion via interfacial engineering in CuZnCeOx/Cu-foam catalyst

Cu-based catalysts are promising for CO 2 hydrogenation to methanol, but their activity and stability are often limited by Cu sintering, insufficient interfacial interactions, and inefficient heat transfer. Herein, a novel CuZnCeO x /Cu-foam catalyst was developed by growing Cu(O...

The glymphatic–lymphatic axis: known pathways, open questions, and emerging roles in neurodegeneration

Abstract The discovery of the glymphatic system and meningeal lymphatic vessels has transformed our understanding of brain fluid homeostasis and central–peripheral communication, highlighting the critical role of cerebrospinal fluid in brain clearance. While substantial progress...

UDSQ: a secure and efficient user-defined dynamic skyline query in online medical diagnosis

With the rapid development of information technology, online medical diagnosis services have become increasingly prevalent. These services improve healthcare accessibility for patients in regions with limited medical resources. However, online medical diagnosis still faces signif...

Insight into fouling mechanisms on inclined tube banks in molten salt heat exchangers for coal-fired boiler

Coupling coal-fired boilers with molten salt thermal energy storage is a critical technical pathway for flexible peak shaving of thermal power units. As the core component, the flue gas-molten salt heat exchanger (MSHE) requires inclined tube bank arrangements to achieve gravity-...

Efficacy and safety of radiofrequency ablation for high-risk locations of T1aN0M0 papillary thyroid carcinoma: a retrospective cohort study

The 2024 Expert Consensus has broadened the potential indications for thermal ablation in papillary thyroid carcinoma (PTC). This study classified PTC nodule locations to assess the efficacy and safety of radiofrequency ablation (RFA) for T1aN0M0 PTC in high-risk locations (HRL)....

Leveraging the Synergy between Mechanistic Insight and Machine Learning for Predictive Structure–Performance Relationships in Organic Synthesis

Conspectus Understanding how molecular structure determines reaction performance is a central objective of physical organic chemistry and an increasingly important challenge in data-driven organic synthesis. As the frontiers of synthetic chemistry continue to advance, predictive...

Cell-Laden 3D-Bioprinted Artificial Skin Grafts for Tissue Engineering Wound Healing

Abstract In recent years, with the rapid advancement of tissue engineering and regenerative medicine, cell-laden 3D bioprinting has emerged as a key driving force in the construction of functional artificial skin grafts. By precisely controlling the three-dimensional spatial dist...

Controlled Ring-Opening Polymerization of 5-Phenyl-1,4-dioxan-2-one toward Stereochemically Tunable and Closed-Loop Recyclable Polyesters

Abstract The practical applications of closed-loop recyclable polymers demand monomers that are readily accessible from simple feedstocks while enabling controlled polymerization and tunable physical properties. Herein, we report a one-pot synthesis of 5-phenyl-1,4-dioxan-2-one (...

Genomic Characterization of Clinical Group B Streptococcus Isolates from Zhejiang, China: Serotypes, Clonal Complexes, and Predicted Antimicrobial Resistance and Virulence Gene Profiles

This study aimed to characterize the population structure, predicted antimicrobial resistance gene profiles, and virulence gene repertoire of Group B Streptococcus (GBS) in Zhejiang Province, China, using whole-genome sequencing (WGS). Forty GBS isolates from clinical specimens u...

MOCA: A Hierarchical Semantic-Enhanced Code Edit Framework for Multilingual Code Co-Evolution

Multilingual code co-evolution aims to propagate code edits across programming languages while preserving functional consistency, yet the task remains challenging in real-world repositories. Our motivating examples reveal two key challenges: (1) Existing models fail to infer the...

Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization

ABSTRACT The hierarchical structure of tooth enamel confers exceptional mechanical robustness, yet its biomimetic regeneration remains a significant challenge. We develop an enzymatic mineralization system (EMS) that achieves enamel regeneration by directing the hierarchical asse...

Physics-informed single-frame end-to-end learning for denoising and background removal in fluorescence imaging

Fluorescence microscopy is often limited by low signal-to-noise ratios arising from the finite number of detected photons and by an out-of-focus background that obscures structural details. Here, we introduce a physics-informed end-to-end learning framework that enables denoising...

Fe 3+ ‐Triggered Scalable Slow‐Corrosion Engineering for Industrial Anion Exchange Membrane Water Electrolysis at 2.0 A cm −2

ABSTRACT The practical application of anion exchange membrane water electrolysis (AEMWE) is hindered by the lack of durable anodes for industrial‐scale current densities (≥ 1000 mA cm −2 ). Herein, we report a scalable Fe 3+ ‐triggered homogeneous slow‐corrosion strategy to fabri...

Damage identification and model updating using bridge displacement under moving vehicles with uncertain weight

Bridge damage incurred during long-term service leads to discrepancies between the physical structure and its digital twin finite element (FE) model, necessitating regular model updates to ensure reliable health monitoring. Traditional methods typically adopt a two-step framework...

Effects of roll motion on air distribution and frictional resistance of an air-lubricated container ship

Air lubrication technology reduces ship frictional resistance by injecting air beneath the hull, yet how ship roll motion alters the near-wall air distribution and frictional resistance response remains poorly understood. This study uses full-scale unsteady Reynolds-averaged Navi...