Zhejiang University

Strain-Tunable Altermagnetism in Bilayer PerovskitesMediated by Jahn–Teller Distortions

Abstract Altermagnetism, a novel collinear magnetic order distinct from conventional ferromagnetism and antiferromagnetism, has attracted great interest for its unique functional properties and potential applications in ultrafast spintronics. However, achieving effective control...

In vivo labeling–based proteomic analysis of early follicle oocytes and cisplatin-induced alterations in mice

Abstract A systematic proteomic profile of oocytes from early-stage follicles, particularly primordial follicles, is critical to protect female reproductive capacity in the context of chemotherapy, yet progress has been hindered by the rarity of oocyte samples and technical chall...

Mechanistic basis of LolDF-mediated lipoprotein transport in Acinetobacter

Lipoprotein trafficking is essential for Gram-negative bacteria to maintain the outer membrane, a permeability barrier critical for survival and antibiotic resistance. While most bacteria employ the canonical LolCDE transporter, Acinetobacter utilizes a noncanonical LolDF system...

Beyond Molecular Dispersion: A Molecular-Cone Architecture of Cobalt Phthalocyanine on CNTs for Selective CO2 Electroreduction to Methanol

Abstract Molecularly dispersed cobalt phthalocyanine (CoPc) on carbon nanotubes can be used as an efficient catalyst for electrochemical CO2-to-methanol conversion. However, increasing the CoPc loading to enhance the current density typically induces aggregation, which compromise...

Post-Printing Manipulation of Material Mechanical Properties via Synergistic Engineering of Dynamic Polymer Network and Phase Separation

Abstract The coupling of 3D printing process constraints and material molecular design makes it difficult to simultaneously achieve sophisticated structural fidelity and desirable mechanical performance. Topological reconfiguration of dynamic covalent polymer networks imparts mat...

Multimember Unit–Based Topology Optimization of Cable-Supported Grid Structures

Abstract Cable-supported grid structures, integrating rigid and flexible components, represent a lightweight and efficient structural form. Conventional topology design methods based on single-member units often produce incomplete upper grids and lower cable-supported structures...

Quantifying the role of nitrogen in achieving global Sustainable Development Goals

Abstract Achieving the 2030 Sustainable Development Goals (SDGs) requires balancing well-being with environmental protection, yet the role of nitrogen across these goals remains poorly understood. Here, we show how dietary nitrogen intake and nitrogen release to air and water are...

Gut microbiota dysbiosis remodels the multi-tissue transcriptional landscape of the host

<title>Abstract</title> Background The gut microbiota exerts a profound influence on host physiology, but its systemic impact on gene expression across diverse tissues remains poorly characterized. Results This study investigated the transcriptional effects of gut microbiota depl...

Separation of xylene isomers in an adaptable metal-organic framework

Efficient separation of xylene isomers by adsorption remains challenging due to insufficient selectivity arising from their molecular similarity. We report an adaptable metal-organic framework, Ni(BIC) 2 [1- H -benzimidazole-5-carboxylic acid (HBIC)], that exhibits high selectivi...

Mechanism and plasticity of primitive pyroptosis

Pyroptosis is a proinflammatory form of regulated cell death across the tree of life. The gasdermin (GSDM) protein family functions as an evolutionarily conserved executioner of pyroptotic cell death by forming membrane pores. As the canonical activation mechanism, proteolytic cl...

Building a Physics-Aware AI Ecosystem for Solid-State Hydrogen Storage Materials

Abstract Hydrogen storage remains a central bottleneck for scalable hydrogen energy systems due to the multiscale and coupled nature of the thermodynamics, kinetics, and microstructural evolution of hydrogen storage materials (HSMs). Although artificial intelligence (AI) has acce...

Erasable PCM-Assisted Probe for In Situ Monitoringof Photonic Integrated Circuits

Abstract Photonic integrated circuits (PICs) are essential for modern optoelectronics, yet fabrication-induced random phase errors often necessitate precise detection and calibration before application. Optical probing offers a direct detection method before packaging. However, c...

Tokenizing Loyalty Programs: The Role of Tradability

Problem Definition. Loyalty programs (LPs) are widely used to enhance customer retention and firm profitability. With technological advancements like blockchain, many brands are exploring tokenized LPs. Unlike traditional LPs, where rewards can only be redeemed for future purchas...

Effect of mesh-belt motor frequency on heat- transfer boundary conditions and quenching distortion of bearing rings

Quenching distortion of bearing rings seriously affects their dimensional accuracy and service performance in industrial production. To address this issue, this study proposes a distortion control method for bearing rings during quenching in widely used mesh-belt furnaces, focusi...

In Situ Tracking of Membrane HER2- Antibody–Drug Conjugate Interaction with Surface PlasmonResonance Imaging

Abstract Antibody–drug conjugates (ADCs) rely on specific recognition of tumor-associated membrane receptors to achieve targeted intracellular drug delivery, yet in situ characterization of their interaction dynamics remains limited. Here, we develop a single-cell plasmonic imagi...

Mefatinib versus gefitinib as a first-line treatment for EGFR-mutated non-small cell lung cancer: a randomized, double-blind, multicenter phase III study

Mefatinib, a novel second-generation epidermal growth factor (EGFR) tyrosine kinase inhibitor that has shown promising antitumor activity in targeting non-small cell lung cancer (NSCLC) with common and uncommon EGFR- activating mutations. In this phase III, randomized, double-bli...

Asymmetry of inter-joint coordination patterns and variability between dominant and non-dominant legs during landing in young healthy adults: a cross-sectional study

Abstract Background Landing movement usually challenges motor control and causes lower limb injuries. Although asymmetries in landing biomechanics between the dominant and the non-dominant sides have been observed, the side-to-side differences in inter-joint coordination patterns...

Codon optimization depletes stop codons in alternative reading frames of protein-coding nucleic acid therapeutics

Out-of-frame translation events, arising from ribosomal frameshifting or noncanonical initiation, are an unavoidable feature of translation. Their consequences depend on the distribution of stop codons in alternative reading frames, which determines the permissiveness of those fr...

A dual-mode radiofrequency ablation catheter with advanced thermal sensing for saphenous and perforator vein insufficiency: a preclinical study on goats

为克服现有进口器械热损伤风险高、 与国内临床常用的 6 Fr 鞘管不兼容等局限性, 我们研发了一款名为 Saphenus 的新型国产射频消融 (RFA) 导管系统。 其核心创新点包括: 6 Fr 外径设计 (适配国内常用鞘管), 独特的双模工作长度设计 (8 mm 用于穿通静脉, 80 mm 用于大隐静脉), 以及优化的温度传感机制以...

Modular reconfigurable underwater robot (MRUR): a comprehensive review of structure, perception, and control

Modular reconfigurable underwater robots (MRURs) have attracted increasing attention due to their potential to overcome the limitations of conventional underwater robots with fixed structures and single-task capabilities. This review summarizes recent progress in MRUR from three...