Zhejiang University

Mendelian Randomization and Machine Learning for Anatomical Subtyping of Adolescent Sleep Apnea

Introduction and aims Obstructive sleep apnea (OSA) is associated with dentofacial skeletal and soft-tissue anomalies, but whether these anatomical pathways contribute independently, and whether they define clinically distinct subtypes, remain unresolved. We integrated genetic ca...

Metal–Support Interactions in Heterogeneous Electrocatalysis

Abstract Electrochemical energy conversion underpins the sustainable production of fuels and chemicals, with efficiency and selectivity governed by reactions at electrified solid–liquid interfaces. In supported electrocatalysts, metal–support interactions (MSIs) shape how catalyt...

Exfoliation of Molecular Crystals Enables Two-Dimensional Polymerization for Stable Photoelectric Response Devices

Two-dimensional polymers (2DPs) have emerged as a class of important materials with the unique advantages of an ultrathin, lightweight nature and a large accessible surface area, showing their promising potential in the area of optoelectronics, energy storage and conversion, and...

From AI weather prediction to infrastructure resilience: a real-time correction–downscaling framework for tropical cyclone impact forecasting

This paper addresses a missing capability in infrastructure resilience: turning fast, global AI weather forecasts into asset-scale, actionable risk intelligence. We introduce the AI-based Correction–Downscaling Framework (ACDF), which combines real-time bias correction, terrain-i...

Group Climate Questionnaire as a Referent-Shift Consensus Measure: Actor-Partner Interdependence Modeling

This study examined the Group Climate Questionnaire-Short Form (GCQ-S) as a referent-shift consensus measure of cohesion among 83 Chinese undergraduates in 15 positive psychology-informed psychoeducational groups over 14 weekly sessions. Using multisample actor-partner interdepen...

First Report of Soft Rot on Corydalis yanhusuo Caused by Pectobacterium versatile in China

Corydalis yanhusuo (Yanhusuo) is a traditional Chinese medicinal herb. From March to May 2023 and 2024, a previously unrecorded soft rot was observed in Panan County, Zhejiang Province, China (N29°12', E120°32'), with disease incidence of 10–50% (up to 80% in some fields). Initia...

Exploring the effectiveness of GenAI feedback in facilitating EFL translation task performance

Despite the growing potential of generative artificial intelligence (GenAI) to transform language education, empirical evidence on the effectiveness of GenAI feedback in facilitating English as a foreign language (EFL) translation task performance remains limited. Informed by a s...

Structure-Adaptive E-Value Filter for Detecting Regional Signals in Brain Imaging

Structural MRI provides a noninvasive view of the neuroanatomical differences associated with cognitive impairment and dementia. Using data from the Alzheimer's Disease Neuroimaging Initiative, we investigate which anatomical regions exhibit widespread gray-matter differences and...

Mastering a simulation-based parametric method to obtain bias-corrected point estimates and sampling variance for effect sizes

Abstract Meta-analyses require an effect-size estimate and its corresponding sampling variance from primary studies. For some effect size statistics, however, estimators of sampling variance are unavailable, requiring new derivations. Traditionally, such formulas are obtained usi...

Three decades of urban densification reduced winter direct sunlight access across China’s old urban cores

Urban densification is widely promoted to improve land-use efficiency and curb sprawl, but it can reduce winter sunlight in old urban cores, an important dimension of urban livability. Although three-dimensional (3D) urban form is known to shape sunlight availability, most studie...

Social capital factors in healthcare AI implementation: a qualitative systematic review

Fragmented healthcare systems often hinder the seamless adoption of artificial intelligence (AI). Traditional frameworks frequently view AI adoption as a discrete technical acquisition, overlooking the socially negotiated processes and team-level dynamics crucial for integration....

Chinese bayberry leaves proanthocyanidins regulate glucose and lipid metabolism associated with the modulation of the gut microbiota-barrier axis

Abstract This study investigated how Chinese bayberry leaves proanthocyanidins (BLPs) regulate glucose and lipid metabolism through the gut microbiota-barrier axis. In high-fat diet (HFD)-induced obese mice, BLPs significantly reduced body weight, improved glucose tolerance, and...

Exponential strain energy density-based dynamic failure criterion for jacket offshore wind turbines under extreme seismic loading

Jacket offshore wind turbines (OWTs) are increasingly deployed in seismically active regions. However, existing failure criteria for OWTs under seismic loading rely on empirical displacement or stress thresholds that lack theoretical justification. To address this, the present st...

Aortic valve disease: Novel animal models for advancing our understanding of the underlying mechanisms

Abstract The global public health burden of aortic valve disease (AVD) is growing due to its high mortality rate and lack of suitable pharmaceutical therapies in clinical practice, a challenge that is largely attributable to our poor understanding of its complicated underlying me...

An integrated approach for multi-species VOC impact assessment from multiple organized point sources in industrial parks using dynamic dispersion modeling

Volatile organic compound (VOC) impacts in chemical industrial parks are shaped by dynamic emissions, diverse source configurations, and meteorological variability, complicating source attribution and exposure assessment. Existing methods often lack source specificity, overlook e...

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

ABSTRACT Extracellular pore domains of ion channels are emerging as dynamic regulatory surfaces, but whether they can be rationally targeted to achieve selective channel modulation remains unclear. Here, using an optimized hotspot‐centric design strategy, we developed Depiv2, a s...

TROP2‐Targeting Chimeras (TRTACs) for Tumor Cell‐Selective Membrane Protein Degradation and Enhanced Drug Delivery

ABSTRACT Extracellular targeted protein degradation (eTPD) systems typically utilize lysosome‐targeting receptors (LTRs) to redirect extracellular and membrane proteins for lysosomal degradation. Expanding the repertoire of clinically relevant LTRs could broaden the therapeutic p...

Distinct neuronal subpopulations in the anterior pretectal nucleus contribute to nitroglycerin-induced cephalic and extracephalic mechanical hypersensitivity

Abstract Background Chronic migraine is characterized by recurrent headache and persistent pain hypersensitivity, often accompanied by sensory symptoms such as photophobia. Although central sensitization within thalamic and brainstem circuits is thought to contribute to migraine...

Assembled Hyaluronic Acid Therapeutics for Targeting M1 Macrophages and Regulating Immune Homeostasis for Ulcerative Colitis Treatment

ABSTRACT Hyperactivated M1 macrophages with excessive reactive oxygen species (ROS) exacerbate intestinal inflammation, driving the progression of inflammatory bowel diseases (IBDs), for instance, ulcerative colitis. Current standard treatments for IBDs show limited efficacy and...

The role of autoproteolysis and mitoribosomal proteins in the regulation of the mitochondrial LACTB tumor suppressor

Abstract Tumor suppressors represent one of the first lines of defense against malignant transformation, and their inactivation in cells leads to the onset of tumorigenesis. Cancer cells employ various mechanisms to inactivate cellular tumor suppressors, including epigenetic sile...