Zhejiang University

Self‐Supervised Internal Learning Enhances Isotropic Resolution for Three‐Dimensional Fluorescence Microscopy

ABSTRACT Three‐dimensional fluorescence microscopy often exhibits anisotropic resolution because axial information is poorly sampled and more blurred than lateral information, which complicates quantitative interpretation of fine 3D structures. Although optical remedies and compu...

Longitudinal Trajectories of the Atherogenic Index of Plasma and Their Associations with Clinical Outcomes After Transcatheter Aortic Valve Replacement

Background/Objectives: The atherogenic index of plasma (AIP) reflects atherogenic dyslipidemia, but the clinical relevance of its longitudinal patterns after transcatheter aortic valve replacement (TAVR) remains unclear. We aimed to characterize AIP trajectories and explore their...

Effective Fuzzing-based Prototype Pollution Detection via Forced Execution and Template Synthesis

Prototype pollution is a critical class of taint-style vulnerabilities in JavaScript programs, enabling attackers to tamper with object prototypes and thereby alter program behavior in unexpected and often dangerous ways. Despite its severity, existing detection techniques strugg...

Spatiotemporal delivery of immune-synapse-stabilizing NK cells for postoperative tumor therapy

Natural killer (NK) cells eliminate target cells by forming an immunological synapse (IS). Here, we equip NK cells with multivalent galectin-3 binding polymers that resemble prehensile “arms” to mechanically reinforce the NK-to-target tumor cell connection. These armed NK cells (...

Volcanic Aerosol Forcing Suppresses Tropical African Rainfall: Mechanisms and Modulation by a Warmer Climate

Abstract Volcanic eruptions are among the most abrupt natural forcings of the climate system and can induce pronounced hydroclimatic disruptions, particularly in monsoon‐influenced regions. Using a 30‐member CESM ensemble, we examine how the 1815 Tambora‐size eruption would affec...

Tricolor soliton molecules in synchronous mode-locked fiber lasers

Tricolor soliton molecules (TSMs), bound states of optical solitons with three distinct carrier frequencies, exhibit distinctive synchronization stability and intricate nonlinear interaction dynamics in synchronous mode-locked fiber lasers. In this work, we experimentally demonst...

Zwitterionic Topological Hydrogel Coatings for Robust Mitigation of the Foreign Body Response

Abstract Implantable medical devices are prone to foreign body response (FBR) during long-term use. Zwitterionic materials have attracted significant attention for their excellent antifouling properties and have been applied to implantable devices to enhance immunocompatibility....

A Narrative Review of Macrophage Plasticity in HIV-1 Persistence: From Tissue Reservoirs to Therapeutic Opportunities

Macrophages are key components of the innate immune system and play multifaceted roles in HIV-1 infection. Beyond serving as target cells for HIV-1, macrophages, particularly long-lived tissue-resident populations, are increasingly recognized as contributors to viral persistence...

Quantum many-body mixed phase space revealed by hybrid feedback control

Abstract Understanding how complex systems transition between order and chaos is a central challenge of non-equilibrium physics. Although weak perturbations of classical integrable systems give rise to a mixed phase space in which regular and chaotic trajectories coexist, analogo...

VSF: A Multimodal Few-Shot Plant Disease Recognition Method in Agricultural Scenarios

Identifying plant diseases presents challenges like small sample sizes, imbalanced classes, and intricate background noise, which constrain the generalizability and resilience of conventional deep learning methods that rely on single-modal images. To overcome these limitations, t...

Structure-Based Optimization of 2-Aminopyrimidine Derivatives as Potent Multi-target FLT3/CHK1/IRAK4 Inhibitors for Acute Myeloid Leukemia

Abstract The efficacy of FLT3 inhibitors is limited by resistance. Co-inhibiting FLT3 and CHK1 can overcome FLT3i resistance, and IRAK4 signaling contributes to leukemic cell survival in FLT3-mutant acute myeloid leukemia (AML). We discovered a novel series of 2-aminopyrimidine d...

Palladium-Catalyzed Site-Selective C–H Arylation of Arenes: Using Diaryl Disulfides as an Arylation Reagent

Abstract The development of site-selective C–H arylation of simple arenes is an urgent yet very challenging task. In particular, the meta-C–H activation of electron-deficient arenes is one of the most challenging substrates for selective functionalization and lacks efficient synt...

On the effective non-vanishing of Hecke–Maass L -functions at special points

Abstract In this article, we consider the non-vanishing problem for the family of special Hecke–Maass L -values L ( 1 / 2 + i t f , f ) $ L (1/2+it_f, f) $ upper L left parenthesis 1 divided by 2 plus i t Subscript f Baseline comma f right parenthesis with f ( z ) $f (z)$ f left...

CoNewsReader: Supporting Comprehensive Understanding and Raising Critical Thoughts on Social Media News Through Comments

Critical news reading (CNR), which requires grasping the holistic ideas of and raising critical thoughts on the news, is beneficial yet challenging for general people who usually get information on daily social media. Comments under the news can aid CNR by providing complementary...

Concrete-filled double skin steel tubes with large aspect ratio under axial compression

This study investigates the axial compressive behavior of long circular CFDST columns through experimental testing and finite element (FE) analysis. Three prismatic and three tapered with a uniform length of 3000 mm and aspect ratios ranging from 10 to 12 were tested under concen...

Persistent Chiral Diradicals via SUMO–LUMO Inversion: Modular Synthesis, Electronic Structures, and Redox‐Switching Properties

ABSTRACT Integrating chirality into organic open‐shell architectures holds immense promise for molecular spintronics and advanced optoelectronics. However, achieving simultaneous chemical persistence, configurational stability, and practical synthetic accessibility remains a form...

Multi-Step Obstruction Reasoning for Target-Oriented Grasp Sequence Generation in Cluttered Scenes

Retrieving target objects in severe clutter requires multi-step reasoning to establish valid obstacle removal sequences. While recent Vision–Language Models (VLMs) have advanced instruction-driven clutter grasping, existing paradigms lack explicit construction of graph-constraine...

Effect of bond performance on flexural crack width of SCBSB concrete beam

Stainless steel-clad bimetallic steel bars (SCBSB) are an attractive choice for durable reinforced concrete (RC) structures in aggressive environments, where controlling crack width is critical to preventing chloride ingress and exploiting the cladding’s corrosion resistance. How...

PEDV evades host immunity through reciprocal stabilization of PLP2 and GSDMD-CT

Abstract GSDMD-mediated pyroptosis is a critical component of the host innate immune defense against viral infection. While the pyroptosis-executing N-terminal domain of GSDMD (GSDMD-NT) has been extensively investigated, the role of the C-terminal domain (GSDMD-CT) remains large...

Miocene northward expansion of the NE Tibetan Plateau via intracrustal underthrusting: insight from Cenozoic stratigraphy and provenance studies

The India–Eurasia collision and continued convergence caused significant uplift of the Tibetan Plateau and intracontinental deformation. However, how this convergence was accommodated at plateau margins remains debated, with two main models proposed: pure-shear thickening versus...