Zhejiang University

Exploring parents’ experiences of palliative care in the pediatric intensive care unit (PICU): a meta-synthesis of qualitative research

Abstract Background When the goals of care for a critically ill child in the pediatric intensive care unit (PICU) shift from curative treatment toward palliative care, parents’ experiences are often complex and multifaceted. This review aimed primarily to synthesize qualitative e...

Hierarchical Sub-Modeling for Electromagnetic Performance Analysis of a 550 kV Mobile HGIS

The 550 kV mobile hybrid gas-insulated switchgear (HGIS) has severe difficulties for electromagnetic performance evaluations due to its highly integrated and compact structure. To address this issue, this paper proposes a hierarchical sub-modeling framework. A simplified global m...

PML Method for the Stochastic Acoustic Scattering Problem Driven by an Additive Gaussian Noise

Abstract. This paper is concerned with the time-domain stochastic acoustic scattering problem driven by a spatially white additive Gaussian noise. The main contributions of the work are twofold. First, we prove the existence and uniqueness of the pathwise solution to the scatteri...

Brain calcification‐associated JAM2 pathogenic mutations impair JAM2 – JAM3 tight junction structure and the blood–brain barrier integrity

Abstract Primary brain calcification (PBC) is a neurodegenerative disorder characterized by bilateral brain calcification. JAM2 is a PBC causative gene, encoding the tight junction protein JAM2 and critical for blood–brain barrier (BBB) integrity, with an uncertain pathogenic mec...

Public perceptions of polygenic testing and embryo selection for non-medical traits

Abstract Some advances in reproductive technologies raise substantial ethical and psychological challenges, for example, the use of preimplantation genetic testing to select embryos based on non-medical traits. While studies have explored public willingness to use preimplantation...

Triptolide sensitizes cancer cells to nucleoside DNA methyltransferase inhibitors through inhibition of DCTPP1-mediated cell-intrinsic resistance

SUMMARY While nucleoside DNA methyltransferase inhibitors (DNMTi) such as decitabine and azacitidine are effective in treating myelodysplatic syndrome (MDS)/leukemia, they have had limited utility for the majority of other cancers. Through a chemical library screen, we identified...

Leptomeningeal fibroblasts promote glioblastoma progression by regulating cerebrospinal fluid dynamics

Abstract Cerebrospinal fluid contributes to homeostasis in the central nervous system, but how its dynamics are altered in glioblastoma is unclear. We find that glioblastoma drives leptomeningeal perivascular fibrosis that is associated with impaired fluid transport and clearance...

Metabolic control of smooth muscle cell phenotype switching in atherosclerosis

Abstract The loss of smooth muscle cell (SMC) contractile phenotype contributes to various diseases including atherosclerosis. However, its metabolic basis is not entirely elucidated. Since the transforming growth factor beta (TGFβ) signaling is among principal regulators of SMC...

HBV re-activation is associated with increased mortality and dysregulation of oxidative and polyamine metabolism in pre-acute-on-chronic liver failure

Abstract Background/Aims Acute-on-chronic liver failure (ACLF) is one of the deadliest complications of chronic liver disease yet treatment options are sparse. In Asia, HBV-reactivation (HBVr) is one of the most common triggers. Recently, HBV-associated ACLF was associated with d...

Reaction-sequence-regulated Y2O3/t-ZrO2 coherent interfaces enable Y diffusion and YSTZ toughening in ceramic coatings on AZ91D magnesium alloy

As a prototypical structural metallic material, AZ91D magnesium alloy is widely used in aerospace and automotive applications due to its low density and high specific strength, but its poor surface durability remains a critical limitation. To enhance service reliability, ceramic...

Resonance Analysis and Coordinated Active Damping of Multiparallel Grid-Connected Converters Under Filter-Inductance Attenuation and Grid-Strength Variation

Parallel converter operation enables flexible capacity expansion of energy-storage power conversion systems. However, parallel converter interactions, filter-inductor saturation, and grid-strength variations increase the risk of resonance instability. The measured current-inducta...

Silk-based materials: Emerging for tendon/tendon-bone regeneration

ABSTRACT: The tendon and tendon-bone interface injuries have long been an issue for clinical practice. Autologous or allogeneic transplantation has been found to be a good method for repairing injuries; however, many factors limit the application of autologous and allogeneic tran...

Observation of Magnetic‐Anisotropy Crossover and High‐Temperature Skyrmions in the Dirac Magnet Fe 3 Ge with a Distorted Kagome Lattice

ABSTRACT Topological materials that simultaneously host robust high‐temperature skyrmions and nontrivial electronic band structures have attracted tremendous interest owing to their distinctive advantages for both fundamental research and prospective technological applications. H...

EquivSage: LLM-assisted Detection of EVM-Inequivalent Code Smells in Multi-chain Reuse Contracts

With the increasing development of Solidity contracts on Ethereum , more developers are reusing them on other compatible blockchains. However, developers may overlook the differences between the designs of the blockchain system, such as the Gas Mechanism and Consensus Protocol ,...

100‐Fold Reductivity Enhancement of Nanoscale Zero‐Valent Iron After 1‐Year Aging in Water via Regulating Corrosion Reactions

ABSTRACT Nanoscale zero‐valent iron (nZVI) is the most promising reductant for in situ groundwater remediation, but its field application around the world is quite limited for decades, due to significant reductivity loss by water oxidation during long‐term (e.g., years) applicati...

Multimodal nanomedicine for precision colorectal cancer management: integrated diagnosis, targeted therapy, and personalized theranostics

Colorectal cancer (CRC) imposes a substantial health burden because of its high incidence and mortality. Despite advances in surgical procedures, chemotherapy, radiotherapy, targeted therapy, and immunotherapy, the overall efficacy is still unsatisfactory, especially for advanced...

Longitudinal Associations Between Overparenting and Emerging Adults' Psychological Maladjustment: The Mediating Role of Coping Strategies

ABSTRACT Introduction Mental health challenges are increasingly prevalent among college‐attending emerging adults. Although overparenting has been consistently linked to psychological maladjustment, the longitudinal processes underlying this link are unclear. Given coping's centr...

100‐Fold Reductivity Enhancement of Nanoscale Zero‐Valent Iron After 1‐Year Aging in Water via Regulating Corrosion Reactions

ABSTRACT Nanoscale zero‐valent iron (nZVI) is the most promising reductant for in situ groundwater remediation, but its field application around the world is quite limited for decades, due to significant reductivity loss by water oxidation during long‐term (e.g., years) applicati...

Upcycling of Polycaprolactone via Nonthermal Plasma‐Enhanced Catalytic In Situ Hydrogenolysis at Ambient Pressure

ABSTRACT Chemical recycling of plastics is typically hampered by energy‐intensive processes requiring harsh conditions. Here, we report an electrified non‐thermal plasma (NTP) catalysis strategy for the selective hydrogenolysis of polycaprolactone (PCL) into valuable caprolactone...

From graph Laplacian to ring polymer dynamics: part I

Abstract A graph-theoretic formulation of overdamped Langevin dynamics and constitutive equations for ring polymers is developed. The polymer molecule is represented as a bead–spring network whose connectivity is described by a graph Laplacian. Starting from overdamped stochastic...