Zhejiang University

Hyperactive lateral hypothalamic GABAergic neurons drive abnormal aggression in neuroligin-3 R451C knock-in mice

Aggressive behaviors represent a common and clinically challenging comorbidity in individuals with autism spectrum disorder (ASD), yet the underlying neural mechanisms remain poorly understood. This study aimed to investigate the circuit-level pathology driving elevated aggressio...

Thermal regulation of monocrystalline and polycrystalline photovoltaic panels using phase change material for high temperature applications

Thermal regulation of photovoltaic (PV) panels is essential, as electrical efficiency decreases with increasing operating temperature. However, the electrical efficiency of these panels still no reach to maximum level, and authors have investigated various fluids and materials fo...

Autonomic regulation as a mechanistic pathway linking transcutaneous auricular vagus nerve stimulation to intrinsic capacity in older adults: protocol for a randomized sham-controlled trial

Intrinsic capacity (IC) reflects the integrated physical and mental capacities of older adults and is a central target of healthy ageing interventions. However, the biological mechanisms underlying IC decline remain poorly understood. Autonomic nervous system (ANS) dysregulation...

Defeating Mechanical-Thermoelectric Performance Conflict in Hydrogel Thermocells via Mechanical Orientation Boost: A Universal Strategy

Abstract The advancement of high-performance hydrogel thermocells is constrained by a fundamental trade-off: strategies to enhance mechanical robustness, such as densifying polymer network or strengthening intermolecular interactions, often compromise thermoelectric performance d...

Unequal paths of healthy ageing: a qualitative exploration of urban-rural disparities in self-management of intrinsic capacity decline

Declining intrinsic capacity may compromise healthy ageing, while opportunities to manage functional change are shaped by social and structural circumstances. Urban-rural differences in the conditions surrounding everyday self-management remain poorly understood. This study explo...

DGSRef: Decoupled Geometric-Semantic Refinement Network for High-Resolution Remote Sensing Segmentation

High-resolution remote sensing semantic segmentation is essential for land-cover mapping, urban monitoring, and object-level geospatial analysis, but accurate prediction remains difficult because remote sensing images often contain complex backgrounds, shadows, weak object contra...

Is the accretion flow magnetically arrested in M87?

Abstract It is still debating on whether the disc is magnetically arrested in M87. We assume that a weak external magnetic field is dragged inwards by the accretion disc, which is substantially enhanced to drive strong jets near the black hole horizon via Blandford-Znajek mechani...

A tendon-targeted zwitterionic nanogel for restraining osteoclast maturation to halt heterotopic bone formation

Tendinopathy is a prevalent degenerative musculoskeletal disorder that can progress to heterotopic ossification (HO), ultimately resulting in tissue stiffening and biomechanical deterioration. However, effective early-stage therapeutic strategies to prevent pathological ossificat...

Equivalent Roughness Height for Nondensely Distributed Submerged Obstacles in Open Channel Flows

Abstract The estimation of equivalent sand-grain roughness height ( k s ) for open channel flows is well-established for densely packed roughness but remains ambiguous for nondensely distributed submerged obstacles. This study presents a practical model to predict k s for such co...

Delivery of CAR T Cells in a Magnesium-Functionated Hydrogel Boosts Peritoneal Metastasis Treatment

Abstract Chimeric antigen receptor (CAR) T cells show limited efficacy in solid tumors due to suppressive factors in the tumor microenvironment. In this study, we identified extracellular magnesium (Mg2+) as a pharmacologically modulable regulator of CAR T activity. Mg2+ suppleme...

Thermodynamics-Based Two-Surface Model for Natural Clays Considering Bonding Degradation and Fabric Evolution

Abstract Naturally deposited clays generally exhibit interparticle bonding and fabric anisotropy, which provide additional strength beyond the remolded state and lead to direction-dependent mechanical responses. During loading, microstructural rearrangement, manifested as progres...

2D Covalent Organic Frameworks as Robust n‐Type Organic Mixed Ionic‐Electronic Conductors for Electrochemical Transistors

ABSTRACT Organic mixed ionic‐electronic conductors (OMIECs) with exclusive electrochemical modulation and coupling between ions and electrons have exhibited intriguing efficiencies in bioelectronics, logic circuits, and wearable devices. However, OMIECs are typically linear polym...

Dual‐Affinity Host Engineering for Highly Reversible Zinc–Iodine Batteries

ABSTRACT Aqueous zinc–iodine (Zn–I 2 ) batteries are promising for large‐scale energy storage, yet their practical development is impeded by the coupled degradation of both electrodes, including instability Zn anode and sluggish iodine kinetics of cathode. Existing approaches typ...

A State-Of-The-Art Review of Industrial Time Series Data Analysis: Methods and Applications

The Industrial Internet of Things (IIoT) is characterized by the generation of vast amounts of time-series data. Modern IIoT systems enable efficient collection, storage, and querying of massive industrial time-series data, making the processing and analysis of such data a key en...

A Knowledge-Enhanced Iterative Reasoning Framework for Accurate and Traceable Fault Diagnosis in Distributed Service Systems

Fault diagnosis in distributed systems is challenged by complex service dependencies, cascading anomaly propagation, and similar symptom patterns. This paper proposes a knowledge-enhanced iterative reasoning framework that integrates large language models (LLMs) with a numerical...

Increased maximum carbon release offsets half of the growth trend in annual land carbon sink

The terrestrial carbon sink has strengthened in recent decades through enhanced maximum CO2 uptake (MCU) and a longer carbon uptake period (CUP), whereas maximum CO2 release (MCR) remains less quantified. Using atmospheric inversion estimates and 16 terrestrial biosphere models,...

Fluorescent protein ticker tape (FPTT): Multiplexed recording of transcriptional dynamics in living cells and in vivo

Recording and real-time imaging of promoter activities are critical for deciphering signaling cross-talk, but technologies for simultaneously capturing multiple transient events in living cells are lacking. Here, we design fluorescent protein–based ticker tapes (FPTT) for multipl...

A data-driven framework for predicting mechanical properties of coal–rock composites in deep mining

Abstract The depletion of shallow coal resources necessitates the advancement of deep mining operations, where accurate prediction of coal–rock composite mechanical behavior is critical for disaster prevention. This study systematically develops and evaluates a machine learning (...

High immunosuppressants variability adversely affects post-transplant recurrence for patients with hepatocellular carcinoma

Tumor recurrence after liver transplantation (LT) for hepatocellular carcinoma (HCC) is the most significant obstacle impacting the prognosis of patients. Managing the clinical application of immunosuppressive agents is difficult, owing to their limited therapeutic range and nota...

A Hybrid CNN-Transformer Network for Linear Noise Suppression in 3D Seismic Data

Abstract 3D seismic data acquisition, processing, and analysis have become increasingly prevalent in modern geophysical exploration. However, various types of coherent noise, especially linear noise, can cause serious interference and effective noise reduction techniques are crit...