Zhejiang University

2D Covalent Organic Frameworks as Robust n‐Type Organic Mixed Ionic‐Electronic Conductors for Electrochemical Transistors

ABSTRACT Organic mixed ionic‐electronic conductors (OMIECs) with exclusive electrochemical modulation and coupling between ions and electrons have exhibited intriguing efficiencies in bioelectronics, logic circuits, and wearable devices. However, OMIECs are typically linear polym...

Explicit depth representation improves the 3D modelling of soil carbon to nitrogen ratio in croplands

The soil carbon-to-nitrogen ratio (C:N ratio) is a fundamental indicator of organic matter quality and nutrient cycling, yet its three-dimensional (3D) variability in croplands remains poorly understood. Accurate mapping of the C:N ratio is essential for evaluating sustainable ag...

A metabolite-pair controlled quiescence switch via ATP-dependent phase separation

Abstract Amino acid oxidation during carbon starvation inevitably generates NH₄⁺ and HCO₃⁻ as byproducts. Here we show that this metabolite pair acts synergistically to deplete cellular ATP, a task neither accomplishes alone. Rather than nutrient starvation itself, it is this spe...

Active Learning‐Accelerated Discovery of Antifungal Polymers With Self‐Assembly Capacity for Tackling Invasive Fungal Diseases

ABSTRACT Invasive fungal diseases (IFD) are life‐threatening infections with limited clinical management. Antifungal peptide (AFP)‐mimicking polymers are promising candidates for tackling IFD. However, due to the structural diversity of polymers, it remains a great challenge to d...

Switching HMF Oxidation Selectivity From FDCA to HMFCA via Carbon‐Induced Constructing Strong Metal–Support Interaction Between Gold Nanoparticles and Al 2 O 3

ABSTRACT Constructing strong metal–support interaction (SMSI) between gold nanoparticles and conventionally nonreducible oxide supports presents a significant challenge, and the mechanistic understanding of SMSI in selective catalytic reactions remains limited. Herein, we demonst...

Auxetic tubes to internal loading: Experiments and analytical modelling

A tube is a common structural component for energy absorption and structural protection against loads, such as pressure vessels in engineering. Auxetic design may improve the performance of tubes in this regard. Little research has been conducted on the responses of auxetic tubes...

Integrated Optimization of Multi-period Yard Template Planning and Loading and Unloading Scheduling for Transshipment Vessels

This paper addresses an integrated multi-period optimization problem that coordinates yard template planning and loading/unloading scheduling for transshipment vessels with heterogeneous visiting cycles. The objective is to minimize container transportation and vessel service cos...

Effects of ketogenic diet on obesity indices, lipid profile, and glycemic control parameters in athletes: a GRADE-assessed systematic review and meta-analysis of randomized controlled trials

The ketogenic diet has revealed more beneficial effects on metabolic health. However, its net effects on atherogenic lipoproteins, adiposity, and glycemic control remain inconsistent. This systematic review and meta-analysis aimed to quantify the pooled effects of the ketogenic d...

The effects of norepinephrine infusion combined with goal-directed fluid therapy on delayed graft function in patients undergoing kidney transplantations: study protocol for a multicenter randomized controlled trial

Chronic kidney disease presents a formidable challenge to global healthcare systems. With ongoing advancements in surgical techniques, kidney transplantation has emerged as a principal therapeutic modality for individuals afflicted with end-stage renal disease, markedly enhancing...

A New Prediction Method of the Constitutive Stress–Strain Relationship for Stainless Steel–Clad Bimetallic Steel Bars

Abstract Stainless steel–clad bimetallic steel bars (SCBSBs) as composite structures exhibit complex stress–strain behavior due to dimensional and material heterogeneity, limiting engineering applications. This paper describes a novel approach to effectively predict the stress–st...

Machine learning-enabled performance prediction and operation strategy of phase-change-material-based thermal batteries

Thermal batteries based on phase change materials (PCMs) are a key technology for energy savings and carbon reduction in building heating since latent thermal energy storage by PCMs with high energy storage density indicates great potential to utilize renewable energies. However,...

Flexible magnetic force sensors: manufacture, mechanisms, and applications

In recent years, flexible magnetic sensors have undergone rapid development in cutting-edge fields such as wearable devices, robotic hand interaction, and soft robotics, demonstrating remarkable performance in sensitivity, multi-dimensional force perception, and deformability. Th...

Emerging nitrogen-driven urban atmosphere control on aerosol iron dissolution for biogeochemical cycles

Iron (Fe) is a critical micronutrient regulating marine productivity and the global carbon cycle, yet its atmospheric dissolution mechanisms remain debated for biogeochemical cycle. The prevailing “iron-sulfur coupling” paradigm has traditionally explained proton-promoted dissolu...

Enhancing Pore-Water Drainage in Coastal Soft Soils: Enzymatic Degradation and Hydraulic Performance of Straw-PLA Vertical Drains

Prefabricated vertical drains are critical for accelerating pore-water pressure dissipation and consolidating water-saturated soft soils in coastal and riverine environments. Straw drainage boards, composed of agricultural straw and polylactic acid (PLA), offer an alternative to...

How Norms Depend on the Presence and Status of Observers: The Relational Contingency of Everyday Behaviors in 90 Societies

Norms are fundamental to social life, but basic questions about how they are affected by social context remain. Specifically, how do normative constraints depend on the presence and status of observers, and how do such relational contingencies vary across cultures? Using data fro...

Genomic predisposition is associated with the direction of sex chromosome evolution

Sex chromosome evolution is among the most dynamic genomic innovations in vertebrates, yet why some lineages evolve XY while others evolve ZW remains unclear. Using chromosome-level genomes from 19 geckos, we found that gecko sex chromosomes originated independently from 16 ances...

Development and Validation of an Interpretable Machine Learning Model for Predicting In-Hospital Mortality in Diabetic Patients with Sepsis-Associated Acute Kidney Injury

Background Sepsis-associated acute kidney injury (SA-AKI) is a common and severe complication in critically ill patients, with poor prognosis. Diabetes may further increase adverse outcomes through infection susceptibility, immune dysfunction, and renal vulnerability. However, mo...

Metabolic-pathway-based classification of tendinopathy reveals a precise therapeutic strategy targeting chondro-modulatory tenocytes

Abstract Tendinopathy is a prevalent degenerative condition driven by complex metabolic dysregulation, yet its inherent metabolic heterogeneity remains poorly characterized, hindering targeted therapeutic development. To address this, we performed systematic multi-omics profiling...

Mitochondrial DNA mutation triggers early-onset intestinal epithelial cell dysfunction during acute colitis

Abstract Background Mitochondrial DNA (mtDNA) mutations cause multisystem disorders often involving gastrointestinal dysfunction. However, the mechanisms governing the selection against mutant mtDNA and the specific impact of pathogenic mtDNA mutations on intestinal epithelial ce...

Mechanistic Insights into the Anti-Inflammatory Activity of a Sulfated α-Glucan (VpG) from Volutharpa ampullacea perryi

A novel sulfated α-glucan (VpG), with an ultra-high molecular weight of approximately 2250 kDa and a sulfation degree of 18.6%, was previously isolated from Volutharpa ampullacea perryi and shown to alleviate dextran sulfate sodium (DSS)-induced ulcerative colitis in mice. Howeve...