Zhejiang University

Long-timescale dynamics shape visual conscious awareness

Consciousness is mostly studied as if it were composed of independent snapshots, aggregating reports over trials and experimental contexts, disregarding any temporal aspect. However, almost nothing is known about how conscious experience spontaneously fluctuates in time. To shed...

Stereoselective polysubstituted bicyclo[1.1.0]butane synthesis by rhodium-catalyzed kinetic resolution

Bicyclo[1.1.0]butanes (BCBs) are a distinctive class of strained small-ring carbocycles of growing importance in synthetic and medicinal chemistry. However, the enantioselective synthesis of polysubstituted BCBs remains a largely unsolved challenge. Herein, we report a general ch...

Antibiotic-loaded PMMA bone cement promotes diabetic wound healing via induced membrane formation: a transcriptomic and mechanistic study

Abstract DFU is a prevalent complication among diabetic patients, significantly impairing their quality of life.PMMA-induced membrane therapy has gained increasing attention as a specialized healing tissue closely linked to bone regeneration. This study aims to explore the impact...

Virtual identity, real perception? Stimulating user behavior and promoting value co-creation in metaverse cultural heritage tourism

Abstract The authors have requested that this preprint be removed from Research Square.

Steering or Stifling? The Role of Overparenting in Emerging Adults’ School-to-Work Transition

The school-to-work transition (STWT) is a critical developmental task for emerging adults and a family project for parents. Amid a global shift toward intensive parenting, this study examined how overparenting—particularly career-specific overparenting—is associated with emerging...

A perspective on training machine learning force fields for solid-state electrolyte materials

Abstract Machine learning force fields enable high-accuracy modeling of solid-state electrolytes (SSEs). This perspective evaluates dataset size, reference quality, and model architectures. We show that crystalline frameworks of bulk SSEs favor efficient learning, prioritizing da...

Dynamic coupling enables impulsive ejection in a hydrogel catapult

Abstract Ejection dynamics can provide miniature robots with high-speed, cross-scale locomotion and non-contact operation. Here, we present a dynamic coupling ejection strategy for generating and transferring kinetic energy in miniature robotics. We demonstrate this strategy usin...

Evaluating Creativity in Generative AI Outputs: Dimensions and Cross-National Differences Among Art and Design Students

Generative Artificial Intelligence (GenAI) has revolutionized the creative industries, prompting its widespread adoption in higher education. However, significant gaps remain regarding students’ perceptions of AI-generated visual outputs across different cultures. Employing a mul...

Modeling Large‐Deformation Geotechnical Problems in Granular Soils: Integrating a Micromechanics‐Based Model With the Explicit Finite Element Method

ABSTRACT Large‐deformation problems in granular soils are of central importance in geotechnical engineering, as they govern the performance of foundations, retaining structures, and earthworks under extreme loading conditions. Reliable prediction of such phenomena remains challen...

Pt–Sb Bimetallic Catalysts for Base-Free Aerobic Oxidation of Diethylene Glycol to Diglycolic Acid

Abstract Diglycolic acid (DGA) has emerged as a promising feedstock for the synthesis of biomass-derived platform molecules, yet its high cost remains a major barrier to practical implementation. Hence, we developed a series of PtSb/CeO2 catalysts for the selective oxidation of d...

G9a-mediated cholesterol metabolism triggers cuproptosis to promote alcohol-related liver disease

Abstract Whether and how disrupted cholesterol homeostasis contributes to alcohol-related liver disease (ALD) remains elusive. Here, we report that cholesterol biosynthesis is enhanced in ALD livers, driven by a reduction in the H3K9me2 epigenetic landscape orchestrated by the G9...

S1P-TREM2 axis protects immunosuppressive neutrophils from ferroptosis to promote tumour progression in hepatocellular carcinoma

Background Neutrophils are increasingly recognised as immunosuppressive drivers of hepatocellular carcinoma (HCC), yet their persistence in the oxidative, lipid-rich tumour microenvironment remains poorly understood. Objective To elucidate the metabolic and molecular programmes t...

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

The Negative Impact of Digital Overload on Civil Servants’ Work Outcomes: The Moderating Role of High-Performance Human Resource Management Practices

As digitalization accelerates, digital overload is placing increasing pressure on civil servants. This study draws on the Job Demands–Resources model and analyzes 3 waves of survey data from 653 civil servants, along with a scenario-based experiment involving 138 participants. Fi...

An ABA /auxin regulatory module controlled by nitrogen governs symbiotic organogenesis in the bryophyte species Ricciocarpos natans

Summary During the terrestrialization of plants c. 470 Ma, overcoming nitrogen limitation was a major evolutionary challenge. While nonvascular plants may acquire nitrogen through rhizoids and surface diffusion, symbiotic interactions likely provide an important strategy to overc...

Cellular Senescence and Immune Dysregulation in Acute-on-Chronic Liver Failure: A Case Report Integrating Single-Cell and Spatial Transcriptomic Profiling

Background: Acute-on-chronic liver failure (ACLF) is a clinical syndrome characterized by acute decompensation of cirrhosis, systemic inflammation, and high short-term mortality (1). The underlying mechanisms involve a complex interplay between cellular senescence, immune dysregu...

Stepwise Hydration Switches Electronic Structure in a Bifunctional Organocatalyst through Double Hydrogen Bonding

Abstract 1,5,7-Triazabicyclo[4.4.0]dec-5-ene (TBD) is a widely used bifunctional organocatalyst; however, its microscopic behavior in hydrogen-bonding environments remains poorly understood. In this study, we employed broadband rotational spectroscopy to identify the stepwise mic...

Melt‐Regulated Crustal Kinematics in the Pamir, NW Tibetan Plateau: Insights From Surface‐Wave Tomography

Abstract The Pamir, located at the northwestern margin of the Tibetan Plateau, is undergoing E–W extension within its interior, accommodated by micro‐block motions along major fault systems; however, the mechanisms governing this modern block kinematics remain elusive. Here, we p...

Multivariate-Activated DNA Logic Gate for Predicting Responses to Cisplatin-Based Chemotherapy

Abstract Cisplatin-based chemotherapy remains an attractive alternative for controlling advanced cancers. However, a subset of cancer patients exhibits resistance to cisplatin. Accurate and early prediction of individual responses to cisplatin treatment is critical to personalize...

Young Autistic Children Spontaneously Take Others' Visual Perspectives

Spontaneous visual perspective-taking is fundamental to real-world social interactions but remains understudied in young autistic children, partly due to methodological limitations. The traditional dot-perspective task imposes substantial cognitive demands, limiting its suitabili...